ID W9H5R2_9PROT Unreviewed; 844 AA.
AC W9H5R2;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Mechanosensitive ion channel protein {ECO:0000313|EMBL:EWY40042.1};
GN ORFNames=N825_03390 {ECO:0000313|EMBL:EWY40042.1};
OS Skermanella stibiiresistens SB22.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Skermanella.
OX NCBI_TaxID=1385369 {ECO:0000313|EMBL:EWY40042.1, ECO:0000313|Proteomes:UP000019486};
RN [1] {ECO:0000313|EMBL:EWY40042.1, ECO:0000313|Proteomes:UP000019486}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB22 {ECO:0000313|EMBL:EWY40042.1,
RC ECO:0000313|Proteomes:UP000019486};
RA Zhu W., Wang G.;
RT "The genome sequence of Skermanella stibiiresistens.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWY40042.1}.
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DR EMBL; AVFL01000009; EWY40042.1; -; Genomic_DNA.
DR AlphaFoldDB; W9H5R2; -.
DR STRING; 1385369.N825_03390; -.
DR PATRIC; fig|1385369.3.peg.2922; -.
DR Proteomes; UP000019486; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR022249; DUF3772.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF12607; DUF3772; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019486};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..844
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004920841"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..202
FT /note="DUF3772"
FT /evidence="ECO:0000259|Pfam:PF12607"
FT DOMAIN 638..704
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 712..795
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 814..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 90281 MW; 0B3BB5C334C25D68 CRC64;
MRKPPSVWFH RPRQPSRTVF ILALLLLTAL SVISPAGAQT APAAPIEFKA ALAGWQAALE
KAANRVARGA LDEAEYQTLR MELSGLLEQA HQATAAAVTE MAVNQQLAEA LGAPPAEGAL
AEAAAVAAER QRLARIIAEL DGRGRQAELI ATRADILMRT ATDKRMRQFT DTLFKRGPLP
LNRSTWTALP PQAAFLRDRV SQAFSATADD PAWADQGFEL AAAFLVALGL AWPVRRWLLG
RFGRRRDITH PTRRQRVVAL AVEVVGRCLL TVLPTVALAL ALRQIMAGDP KTLPLQALIA
AAAGGAAFFL FFSGLAAAIL APDRPAWRLS ALDPVPARSL VNRITLFAVG VGVAGGAVVL
QRTMLSPPEL QAVTGFGTML LATATLMFLL PGKLWVPRSA GPAPEAGRDA GPEPSGGSWV
QLRHIGGVIA LATLGASIAG FHNLSIYVGM LALATIAVAG LLLPLRGVAH EGVAMVMERE
RGPLAELRRL LVRSEKGVQA ADWCARVMID VGLIALAAVI LLPLSGIDWT ELQGFVDTFM
RGVTVGGVRL APADIIAAIL LFSAAVMVTR HVQRVLDVRV LQRLQIDRGV QNSIKTGVGY
FGFMVALLVA IGALGLDLSN LALIAGALSV GIGFGLQNVV SNFAAGLILL VERPIKVGDW
VVVGDMEGVV KRISVRATEL QTFQRASVII PNSELVSKAV VNWTFKDKFG RIDIKIGVEY
GSDLKLVRET LLACATAHPR VATMPAPMVV FKDFGASSLD FELRCFIPDV DFFLPTASDL
RFAIAESFDR AGIAIPFNQQ VMHIPQLDGL RDFLDRRSPP RQPPAASQLE TITPNSWTGN
VGSR
//
