ID W9HBG0_FUSOX Unreviewed; 2093 AA.
AC W9HBG0;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=FOYG_17266 {ECO:0000313|EMBL:EWY79572.1};
OS Fusarium oxysporum NRRL 32931.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660029 {ECO:0000313|EMBL:EWY79572.1, ECO:0000313|Proteomes:UP000030753};
RN [1] {ECO:0000313|EMBL:EWY79572.1, ECO:0000313|Proteomes:UP000030753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FOSC 3-a {ECO:0000313|Proteomes:UP000030753};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum FOSC 3-a.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; JH717860; EWY79572.1; -; Genomic_DNA.
DR HOGENOM; CLU_001248_5_0_1; -.
DR OrthoDB; 2672428at2759; -.
DR Proteomes; UP000030753; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR046700; DUF6570.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF20209; DUF6570; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000030753}.
FT DOMAIN 346..489
FT /note="DUF6570"
FT /evidence="ECO:0000259|Pfam:PF20209"
FT DOMAIN 708..925
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2093 AA; 237063 MW; DE3D1E00C002389C CRC64;
MESDLRNGKL RVPLEEVNRT IDGLDRRHTE RTAHRRDGGR QQEASKPQTQ GEKVMGPLEE
ITCTLADLDR QHTEESIHRR QGERPQEAVE SQLRDGRLGL PVEEITRTSK NLDRQHAEET
LHRTQGTVRQ GKILLPPEEI ARTLDELNRR YSGGTARPRT CDDLDRQRAR DTELVQGPST
PEPTFRPPQT PPSRKRHRTQ QEGLLTPPPS GPSRSRKRPR LLDETVQLQQ QPLDEFLQYR
ESCFHAKRDA SLSRSWCKEV PLALQVETSK SFYEAFTDER TLPISHCTFC YRKCPPANIT
TIHWRTYLTP ALLQATTALQ KCKKCLPQGG DMGVDICLEC RGVFENGKLP KACSVNNMDI
GCEHRYPREL DGLSPVEERL IALQAPFGYI TKFTVDNKTP SGVSYRKHVK GHIVVFPNNV
DDLVATVLPH PLLQTIENIH VSWSGANRPS PAEVGTLLQV RKSRVTAALL WLQRNNPLYR
DIEINLDEIQ GWQYAEGSTV PTALMERMQR EEPSAVEKTH TDPIVPNTDR GLEENRFTSI
EDLLTSLQPD PSDDTPISVA NASMEQPHPP PEDAHMSAPD PESLDRDGDI LYETSTSGMF
PLDGPAAFAE ADKLSFLAEA IQPSHTGHGN DVEPSAMAVH AAGDQPFIRV ERGADFADNL
HEDFFPRTFP KLFPWGRGGP KALSEPDGNL HDASEPARRS GNHSLNYWAK YVLQRHGGRF
ATHPVFCFLV FNLLLRSTNR RISMVRMTRG SFDRLERVYG SLTADRLKIA EEEMRETRTT
TDPDISFLLR ELSIFGHAQP LSNETRLLMR RKIQAVNIWT GMPAIWITVN PNDINNPVKM
WLSIHRLHDY DTAKELLADL RGRYDRIALS TMDPVSAAIF FHREISLFFE KYVRAGQESI
FGKISHYYAT VETNDRGSLH LHGLLWLEGN MRLPSLIDEM ANPEEEEYRG QVVRYLDSVF
HECLDEEAGK AIRKERKPID PVEEIMHDTE ALAAAFDNES NYIAYCCQVH SHTYTCIKYS
LKRLVGEGAD KHKKRTACRF KAPWRIVEDT GFTEDGLLKI RRNHPLVNRY NKAMAVGLRH
NHDISMILTR TKGLAMVFYI TNYATKLDTP MWKRLVFAAD VLRQLRESEG HPRPNLAEQD
SRRQAVVNES RQFLMRSANR IFSERQLSAV EVCYFLLGYQ TDFTNVPQWS YINLTALYWT
IFRRWTHLRR QASTQTDAEE PSETVQFRES GRTLLYLDAY AYRGPVLREV CLYDYMSMIT
LERRHGRDED EAYIALEGPP ECYGWIQKLR EPPEYAVPIF QGFISDDHMD EHPVYFKRNS
VLHLALFVPW ENFLSETQGD ITGIWSNYAA TLCPRLRSHV SNISLLRKSA EDARKDAKLW
ASRSEGDDTV DVDFPLDEGD YSDEPTMAEH HQTYTALLQT LRSAVRDSDA TRDSPVLQSL
IQDLCYENPV EEDRPFVQRH DNFYQQIRYN QNSPLSQCPI PSAQDLQAAA KAQDMLHLRM
LDEMEGGIQG GTTSIGGADV DDLLVRQCDT EIPIPRQHGY PVTQNPRMFV EVGPARGFVE
LGLLAASSYT LNDLQSMALQ LVCRFLDNYI ANPDSAGQHL QYVGGPGGTG KSRIVDALRD
VFTARDQPHH LHITGTSGSA AAQIGGTTLH SALGLDTHRS HDKQKPPIFS EAKKWMWKQK
LVLVIDEVSM LGGATLFHAN CHLQALRDCP DKPFGGIPVV LLMGDFYQFA PVLETSLLVD
RMVDLAYTAS LGQATIAHHR GHSLWLLFKT VILLEEQVRA RDDPQLGALL DRVRAGTQTT
EDLDLLNTKL VDRSQVTFKD GLRAITPLNR NRWSLNMEAV VGWARFHRRH ISVFVSSHTW
RSRALSQQEV AQTIEQGDNS NCKIPGVFFY AQGMPVVVNK NTYTGLKVVN GAEFTAADVI
PDPKSPGYHL ADDVTIHFGP PLGILLESQE TKDLAIPALP TGTVLIRPTT HTLDPANSHY
RFLSGKCARR GLPVVPAFVL TDYKAQSKTF VEVLLELRGN RMTNGQPSKC DFTSLYVQLS
RCRTLQGIKL LSPVRPQDFI GNKLDQNIID AMQRLTDLAA ETRRLFESQQ GFA
//
