ID W9J693_FUSOX Unreviewed; 544 AA.
AC W9J693;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00019988};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
DE AltName: Full=Glucosylceramide synthase {ECO:0000256|ARBA:ARBA00031543};
DE AltName: Full=UDP-glucose ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00032575};
DE AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase {ECO:0000256|ARBA:ARBA00031017};
GN ORFNames=FOYG_01746 {ECO:0000313|EMBL:EWZ02483.1};
OS Fusarium oxysporum NRRL 32931.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660029 {ECO:0000313|EMBL:EWZ02483.1, ECO:0000313|Proteomes:UP000030753};
RN [1] {ECO:0000313|EMBL:EWZ02483.1, ECO:0000313|Proteomes:UP000030753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FOSC 3-a {ECO:0000313|Proteomes:UP000030753};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum FOSC 3-a.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; JH717839; EWZ02483.1; -; Genomic_DNA.
DR AlphaFoldDB; W9J693; -.
DR HOGENOM; CLU_030898_1_0_1; -.
DR OrthoDB; 2786173at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000030753; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030753};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EWZ02483.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 60943 MW; C5B67353866EC24E CRC64;
MHIPCILFNF HSPIRAIMWS LKEVIAGVFL AVAGLVATVI AIGVRAIFRN FASRPAPSPN
LGDNTPHVTI IRPIKGVEPR LYDCIAASFR QNYPQDKISI RLCLENDTDP AYPILQRVLE
DFPGIDARIL FEVDDLALGT TPNMGPNPKI RNLSRAYREA RGDIVWIVDC NVWMAKGVLG
RMVAKLKGHN VGGDNIPYKF VHQLPIVVDL IDYSTPVAAD GQPLLAASSV EDDDSDHLGG
EGGSHDNPKV WAQGGGRLDE MFMATSHAKF YSAINTSRLA PCAVGKSTMF CKTQLDHATD
PALNPKIPRG KSLPTGVDYF SHNICEDHMI GDVLWNAEFA GYRNHGLVWG DIAVQPMSDM
SVKAYAARRS RWLRARKFTV LPATIFEPFT ESFVFATYFT FAVTTLRIYG IPPTWPARVI
TWLTTITVWM LVDFLGYRHL HSGVTMEVDE DTPRFARGSM NRDGIKSRKF SEFLAAWIVR
EALALPIWAY AVVFGNTVNW RGRRFRIRRD TTVEALDPEE EERSRQVPTP ELERGSSQNK
QRVD
//
