ID W9J9D3_FUSOX Unreviewed; 3860 AA.
AC W9J9D3;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:EWZ02246.1};
GN ORFNames=FOYG_01593 {ECO:0000313|EMBL:EWZ02246.1};
OS Fusarium oxysporum NRRL 32931.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660029 {ECO:0000313|EMBL:EWZ02246.1, ECO:0000313|Proteomes:UP000030753};
RN [1] {ECO:0000313|EMBL:EWZ02246.1, ECO:0000313|Proteomes:UP000030753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FOSC 3-a {ECO:0000313|Proteomes:UP000030753};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum FOSC 3-a.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; JH717839; EWZ02246.1; -; Genomic_DNA.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000030753; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000030753}.
FT DOMAIN 2669..3226
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3505..3831
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3828..3860
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 163..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2030..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3235..3334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3297..3324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3860 AA; 441460 MW; 6A9A7B85A00DBDE5 CRC64;
MSGTTIDDVV KRLSATDIDV RLKLEAATTL RDSLDHYTSG QIYPPFLKRL MPIFFTILRG
PCIFQSNSPD QKLRMAILEV IHRLPTQPAP PEPFEPHAEE TVDLLMQLVR TDNEENATIC
VKIISDIMRH QHKVLQGKVQ LFLTLIQELF EQMEKVVREQ LDNAPHNAPS QPGAPSTPGN
SQTNFQSPRP GSPVASVNDL GTDTQQQNRP LLKGMHSFKV LSECPIIVVS IFQVYRNTVQ
QNVRKFVPLI QNVLCLQASA QQQAHADAAA KGTIHTGVSP AIKNRVAFAD FITAQVKTMS
FLAYLLRQYA SHLNDFLPRL PDIVLRLLKD CPREKSGTRK ELIVAIRHII NYNFRKIFIP
KIDELLDERT LTGDGLTVHE TMRPLAYSML ADLIHHVRDS LKPEQIRKTV EVYTRNLQDN
FPGTSFQTMS AKLLLNMAEC IAKLPNKVDA RHYLIMILNA IADKFAAMNR QYPNAVKLSA
LYREQMKAGT PETYLADKDS PPDWDETDIF SAVPIKTSNP RDRGADPVVD NKFLFRNLMT
GLKNTFYQLR TCNVGSPIDA QNAPTHWQDV SYGFTAEEVK VIIKLFREGA YVFRYYEIEK
PAAESQYMSP VEYMANFYMV SCSKEEKDLL ETFATVFHAI DPATFHEVFQ QEIPHLYDMI
FEHTALLHIP QFFLASEATS PSFCGMLLQF LMERIDQVGS ADVKKSSILL RLFKLAFMAV
TLFANQNEQV LLPHVVNIVT KSIELSTKAE EPMNYFLLLR SLFRSIGGGK FEQLYKQILP
LLEMLLDVLN NLLMAARKPS ERDLYVELCL TVPARLSHLL PHLSFLMRPL VVALRAGTDL
VGQGLRTLEL CVDNLTADYL DPIMAPVIDE LMTALFDHLK PHPYSHFHAH TTMRILGKLG
GRNRKFMTSA VPLTYREYAD DPSSFDLRLL GSKKDRAFPA DMGIDFAIQK LMEFPKATKN
NHNKQYDGYY KKQALHLIKA QLKLRIGYDQ LPDDLPRLLR LQAEDLVARR YEINTANFEI
SDRERSIPKK ESEDLVVKRL LKAIMFAHSF PEFKDEASTF LLNVCKHFAI IEIGRALVDL
KRTFSPFDPN AGEGPLHIDT RNLSDAIVES LASDHPDVRE AGKSAIREMY DATAIIFGSE
SDVGKLPFFS HLSSTFCHSC YEEEWFTKTG GSLGINYLLT ELDLGDTWIT SKQTEFIRAL
TYVVKDMPQD LPEKTRCLAQ TSLEVLLKRI TKDITKEDTL PITQQPGQPQ NPQLKQPRLS
QICQQFGNDL YHMNKHVRET AKHSLELIAT AAKCEVWELL EPCKDKILQP IFAKPLRALP
FSIQIGYINA MTYHMSLKND WVPFDENLNR LLMESLALAD ASDESLANKP AEFRTHEHIV
NLRVSCIKLL TTAMTFEEFS NQPTKTKILS VFFKCLYSES KPTIIAANDA LKSVLSVDRR
LPKELLQGGL RPVLQSLSDP KRLSTAGLDN LSRLLKLLTS YFKVEIGARL LEQIDSIVEP
SALQQISFTF FDQHPQMKII TAILTIFHLL PAPAEAFKER LIDCFLGLEE KLRRTQLSPF
RLPIYRYMNR YPKEIWAYLF GKVEDLKYGR LLAQVLAHAD SSALREVAIE NLDGLITRCN
ELISQNNDAK FIAMVNAIHI FESLSHFPSA EKWMDKKEHL DWLKSIGKEL ETHLRQHTLP
AHLRLPAYQA AEELMTILVK SLERAPKDLD PLFNLIECVT SDELRITQEL FSFIYQKIIC
SDAVDFWKTI VLRCLDTYAG KSASNKMKHF LLHYIVNPIV AMDVMRNWKQ LDQNRTPRLM
DRTVIDAVSS KIWKVQPEST TDDQAQPGID HTRYEVLQLS AMLVKYYHTP LQDARKDIIK
FGWTFIRLED VINKHAAYVV IGYFIAHYET PPKIVTQVYL SLLKANQNEG RALVTQALEL
IAPMLPKRCG TGQNERVAAW AIAPRRVLVD EGQNAQQMTS IYHFLVRHPD LFYEARDRYI
TLMISSLRKL ATPQNASHES KRLCLNMMWL IWTWEERRVE GKSAAFGARS LSQSPNTKKR
KLESDQANTS SQPVGRAEYQ IPPLFRLKMI KYLVEFIAQL NERYELPSAK PRDHVSSSIP
PVPLALTDLC KKAMKLLYNL VQPQYWGDLD LDLFPNVTQV ILASERTQTI LTADPTDKEK
FDDKFLTNII NTLQVVRIVL NSKSDEWIQK SMPAIQKVLE KCLKSENPEI QDCLHLSDKK
FDDNRELRSI VKRILDSVPD DTPMEDADAD GETETQTSEI VAYLSQVATE AMNSSNFTSG
VNILWSLGQR KPNVIDQHIN SLMKALQSKH AREHVQHYNA IANQAAGVNR NQDPNTPSGE
MSAYDLEIQT KIMIKEIQVV ALRMEVLGDN RRPFLSVLAT LVEKSMSIEL CEEILNMVEG
WVFRSEGTWP TLKEKTAVLH KMLSFEHRQD PTMLSKFLDL VIRIYEDPKI TRTELTVRME
HAFLIGTRAA DVEMRNRFMA IFDKSLSKSA SARLSYVLTS QNWDTLSDSY WLAQATQLLL
GAVETNANIQ LYQNDFRTLP ISRLLTIFTK EMEAREPTVI IDDKFESFMA THRRFMSELG
DIKVKDVIEP LVQLQHVDSQ LAHNLWVTLF PIYWSSVAKD DRVDLERGIV ALLTKDYHSR
QIDKRPNVIQ SILDGAAKTW PECKIPPHVL KFEAKTYDAW YTALVQLENS AIKPQVDSAT
VRESNLDALV ELYASLQEDD LFYGTWRRRC QFVETNAALS YEQNGMWDKA QKLYENAQIK
ARTGVIPFSQ AEYMLWEDHW VLCAQKLQQW EILQDFAKHE NFQDLLLECA WRNTEMWQDE
QHREALDNII KGVMDAPTPR RAFFQSFMSL LKFHNQKEAS TDFARVCDEA IQLSIRKWHQ
LPERLTNAHV PLLQNFQQLV ELHDASVICQ SLANTNQTNL DVKSGELKLL LGAWRDRLPN
VWDDITAWQD LVTWRQHIFS LINQTYLQLL PQQGQQNAGG ASSFAYRGYH ETAWIINRFA
HVARKHNLPD VCINQLSRIY TLPNIEIQEA FLKLREQAKC HYENPEELSS GLDVINNTNL
NYFSPSQKAE FYTLKGMFLE KLKQKDEADS AYGTALYFDI GAAKAWAEWG YFNDRKFKED
PTDLNAARQA LTSYLQAAGS YKNAKSRKLL ARILWLLSLD DAKGTIALGF DDFKGETPVW
YWITFIQQLI TGLGHKEAPR VFQLLLKIAK SYPQALYFQL RTNREDLLVI KKNQEARDRT
ARQRAQSVAS NGKASASPSM TKQDPPRPGT ASSRPGTANA TDGTPVKAEG EANGSNAAGT
PAPTNGQTPD PSKAAQKATP QPGQPGQPQK KPPWDYTEEV MSVLKTAFPL LALSMETMVD
QIQKNFKCPP DEDAYRLIVA LLNDALAYVS RTPPSFAKNV KLPAATETNI TRFAETILPS
HIKKSFEADF VTVKPTMYEY IYKLRRWRNK FEEKLDHRIP RAFLENFSPH LSEFRYGKFD
EVEVPGQYLQ HKDKNQDFIR IDRFLPNIDL VRSISASYRR IKMRGHDGSI HKWAIQHPAA
RHCRREERIL QLFRSLNQTL GRKKESRRRD LQFTIPIMVP FAPHIRLVQE DTSYTTLQGV
YEDHCRNMGM SKDDPVLFTM EKLRGALESK SSNKPEQAAT ARLEVFNAIQ EKWVPSTVAI
EYFQKVFPQF AEFWLFRRQF SYQLAALTFI TYIMYMHNRY PQKINISRAT GKVWGSEMMS
YMSANKPFFH NPEPVPFRLT PNLQTLMGPL ATEGIFACSL MAIARCLTEP EYELEHALTL
LVRDEMLFWF TGSHRNGVIT EGQLRDSVQV NSESIVKRAL SLAHSPVGNL PANQTVIDAI
AKAVNPMNLA QCDALWMPYL
//
