ID   W9QRG8_9ROSA            Unreviewed;       867 AA.
AC   W9QRG8;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Cation-chloride cotransporter 1 {ECO:0000313|EMBL:EXB51961.1};
GN   ORFNames=L484_019738 {ECO:0000313|EMBL:EXB51961.1};
OS   Morus notabilis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX   NCBI_TaxID=981085 {ECO:0000313|EMBL:EXB51961.1, ECO:0000313|Proteomes:UP000030645};
RN   [1] {ECO:0000313|Proteomes:UP000030645}
RP   NUCLEOTIDE SEQUENCE.
RA   He N., Zhao S.;
RT   "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KE344058; EXB51961.1; -; Genomic_DNA.
DR   RefSeq; XP_010092664.1; XM_010094362.1.
DR   AlphaFoldDB; W9QRG8; -.
DR   STRING; 981085.W9QRG8; -.
DR   eggNOG; KOG2082; Eukaryota.
DR   Proteomes; UP000030645; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF100; CATION-CHLORIDE COTRANSPORTER 1; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030645};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        133..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          138..433
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          548..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   867 AA;  93714 MW;  A0884A9799A488D0 CRC64;
     MDNGDIEGGP EDNFHAPIGR KYRPVVDNDS AVLEMSSIDP SGSSSSSSAL PLPQAPLKKV
     KVSSQENMDS TVNEEMNGPQ RESKLELFGF DSLVNILGLK SMTEEHSAEP SSPRDGENIS
     ITHGRPKTSD IKLGTMMGVF VPCLQNILGI IYYIRFSWIV GMAGIGQSLL LVAICGLCTF
     LTGISLSAIA TNGAMKGGGP YYLIGRALGP EVGVSIGLCF FLGNAVAGAL YVLGAVETFL
     KAVPAAGIFR ETITRVNVTV VAEPIQSPSS HDLQIYGIVV TILLCFIVFG GVKMINRVAP
     AFLIPVLFSL FCIYIGIAAA GKDHPATGIT GLSLESFKEN WSSDYQNTNN AGIPDPDGEV
     SWSFNAMVGL FFPAVTGIMA GSNRSASLKD TQRSIPIGTL SATLTTTAMY LVSVLLFGAL
     ATREKLLTDR ATIMAPKPAD GERVSAVEKG LPAVQEEVQV LPPASFPTSG RSCGKGLAGG
     SRGGASASFG QLPHLWEEVT GLRSELGAQI GEVQGSVGEE AFVERRCLWR GDNRNELRRE
     EQIGDIRGLG QTDLDQKQAE SRRGGQSGGD MGAELLDLVD FMVVLNISFN RKYRFGKIKK
     LTRKFEAISV RIMELTELVV PFDASRSKLI KIGSGFEPER TKTGWLTLKI KLDVILGRNS
     DGSFSLGTRG RKKGTVVEEM GNTGMVHFTG TQQQRREVSN NYKQTFPRIF ERERGMEALS
     TEGNMAEIAK SWGMAVVVTR RSVDTEWWEL KETIGSRVAR LVEVVPLTAD GAVIWCKDEA
     ERNKLLTKRL SWEKLFGGLL EIAEDTLEKS FLMFAKIKVR GFKDGITEGN KVVGEVNQAH
     SEIEPISIGL TKGNQEEGAG KAFLSKP
//