ID W9R641_9ROSA Unreviewed; 768 AA.
AC W9R641;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=L484_027321 {ECO:0000313|EMBL:EXB38887.1};
OS Morus notabilis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX NCBI_TaxID=981085 {ECO:0000313|EMBL:EXB38887.1, ECO:0000313|Proteomes:UP000030645};
RN [1] {ECO:0000313|Proteomes:UP000030645}
RP NUCLEOTIDE SEQUENCE.
RA He N., Zhao S.;
RT "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000256|ARBA:ARBA00003861}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE343704; EXB38887.1; -; Genomic_DNA.
DR RefSeq; XP_010090090.1; XM_010091788.1.
DR AlphaFoldDB; W9R641; -.
DR STRING; 981085.W9R641; -.
DR GeneID; 21409944; -.
DR KEGG; mnt:21409944; -.
DR eggNOG; ENOG502QQ92; Eukaryota.
DR OrthoDB; 1118232at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000030645; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR CDD; cd01989; STK_N; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR006016; UspA.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR PANTHER; PTHR45647:SF65; U-BOX DOMAIN-CONTAINING PROTEIN 34; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF00582; Usp; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000030645};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 414..677
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 696..768
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REGION 174..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 273..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 174..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 441
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 768 AA; 85887 MW; 6240D8C178972D82 CRC64;
MNRDGGFAVP AAMTSVAVAV HGGGGNDSRR AVKWAVENLW PRADRFVLVH VVPKISSIPT
PSGDFIPVAE LDEKMVAMYV QDVKEKLEEV FVPFKKLCRT REIETLILDD DDPAKALLRY
ASESGISCLV LGSCSSNFLT RKLKGPGVPE IVLRCTANAC DIYVVSKQGV ITKAANPSSS
GETSTARQSS TQRDHGLGLH GLGEQISGFR SFSAESQVSE TFGASTMSVL SYLNSEAFTQ
ICSPTNTSIH EGNRYQDLEA GLETHTLRQC HSMASLNIDK SHAQAEVEQL RRELQSTITM
YNRACEELVH AQKKVQLASS VCLEETRRVD AALEREELLK KIAAEEKAKH LGAVQEVETA
RALLAKETYE RQIAEVNAFE ESFEKSKLID ALFSSDKRYR RYTRKEIEIA TNFFSETNVI
GEGGYGKVYK CNLDHTSVAV KVLQSSAAEK KQEFLKEVEV LSQLHHPNIV LLLGACPESG
CLVYEYMENG SLEDYIFRRK GKSHLPWFVR FRIVFEIACG LAFLHCSKPD PIVHRDLKPG
NILVGRNFVS KIGDVGLAKL ISDVVPDNIT EYRDSILAGT LFYMDPEYQR TGTIRPKSDV
FAFGVIILQL LTSRHPKGLL LTVKNAIRNG SLVDILDKSV TDWPLIETEE LARLALKCSK
LRCRDRPDLE TEVLPVLKRL VDKANARAKV ERNNTHAPGH YYCPILQEIM DDPHIAADGF
TYEYRAIKAW LEKHSVSPVT KRRLQHSMLT TDHTLRSAIN DWRSHMTF
//
