ID   W9RIK1_9ROSA            Unreviewed;      1337 AA.
AC   W9RIK1;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=L484_011575 {ECO:0000313|EMBL:EXB79635.1};
OS   Morus notabilis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX   NCBI_TaxID=981085 {ECO:0000313|EMBL:EXB79635.1, ECO:0000313|Proteomes:UP000030645};
RN   [1] {ECO:0000313|Proteomes:UP000030645}
RP   NUCLEOTIDE SEQUENCE.
RA   He N., Zhao S.;
RT   "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR   EMBL; KE344789; EXB79635.1; -; Genomic_DNA.
DR   RefSeq; XP_010099569.1; XM_010101267.1.
DR   SMR; W9RIK1; -.
DR   GeneID; 21394827; -.
DR   KEGG; mnt:21394827; -.
DR   eggNOG; ENOG502SI7S; Eukaryota.
DR   OrthoDB; 714410at2759; -.
DR   Proteomes; UP000030645; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR045344; C-JID.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR011713; Leu-rich_rpt_3.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11017:SF588; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF20160; C-JID; 1.
DR   Pfam; PF07725; LRR_3; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030645}.
FT   DOMAIN          17..181
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1337 AA;  153098 MW;  57E89BDF42FF51DD CRC64;
     MVNICSSSSP SSSSLQEKYD VFLSFRGEDT RENFISHLYD ALCRKKIETY IDYKLERGDE
     ISIALVKAIH GSRLSIIIFS ENYASSPWCL DELVHILRNK EKNGHLVVPV FYRINPSHIR
     KQQESYGIAL TVLEERFKKG RVNQWRNALT AAANLSGWDS LVTRPESKLV EAIVEDVLKK
     LSCLSAFDDF KLGLVGIDKR IEEIIPLLRI GSLDVRIIGI WGMGGIGKTT LASVVFNGLA
     SQFEGCCFLE NVREESEKHG INYLRKAFFS KLLEEENLDM GPLCVGTTFI KNRLRRKRVL
     IVLDDVNDLD QLEHFVGDRN WFGPGSRVIV TTRDMQMLRN EVDEIYGVER LNFAEAVQLF
     NFNAFRRSSP TTDDIELSER VVKYAKGVPL ALKVLGSFLR GKRKENWESE LDKLEVVPNI
     KIQNVLRVSY EGLDKKEKNI FLDIACFFKG MERKYVEQIL DACGFFAKIG IDDLIDKSLV
     IIKDRNILWM HDLIQEMGWE IVRSIEEIRK RSRLWIAEDI NHVFKHQKGT GAIEGIFLNM
     SEFRDFQLCP EVFKEMCNLR LLRVYYSSHI KESKVYLPLT LQFLPNALRY LDWYEYPLKS
     LPSSFIPRNL VELDMRYSQL ERLWDGVQDL INLRHIDLGH SKRLTQVPDL SRAPNLESIN
     LECCISLLQV PSLIFKTLDK FRTSLDMGYC EDICCLKERP HPRALGTVNL DGCSNLKSLS
     RFDGNMKYLH LSNTAIQIFP SSICSVNNLV SLNLSNCLWL KNLPTSISKL ESLHVLNLSG
     CSSLDKFPEV PKNVRDLNLR ETALEQVPSS VMRLSYLKTF HLGNCKRLKS ISPSICKLKS
     LGLFDLDGCT NLEDFPEILE PMELLEQLDL RETGIKRLPF SIEKLVGLCS LSMRSCENLE
     FVPCSIYNMH RLESVFFSSC SKLENLPPMS DLCHLAYLDL SYCNVLEIPD SLSCLSSLTT
     LDLRGNMFCS IPASIKQVSK LKVLKLSDCK NLQSVPQLPL SLESLNASGC ELLAEVSHSK
     TAFTQGHIDY NVIHSWDFLF YGCLKLNQNA RDNTMTEFQS RVLQTSTISV SNPEELEDSE
     VLKSSEYLEV SVCFPGLEIP KWFNHQSEKS SINIELSPHW HDTNFLGFAL CAVVAFGDYH
     CTFNYLNFYC ELHFKTEHGK SDTLSWSFPC WENGELEQLE RTIFSSEHVF MLYKHESYRD
     CFDGAVEVSF EFLVRNDWGQ LLESNDCIVK RCGVRLLSLQ DVEEFHFVNN QYEFGQSDAA
     FDEPEPNSNG AVHFVIGEGK DEGLRESDTN QAQLLDELSK EIQNLDINTV ETQQLDELME
     NIMNYFNTST EDPSTTH
//