ID W9S2B9_9ROSA Unreviewed; 534 AA.
AC W9S2B9;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN ORFNames=L484_023437 {ECO:0000313|EMBL:EXB83831.1};
OS Morus notabilis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Moraceae; Moreae; Morus.
OX NCBI_TaxID=981085 {ECO:0000313|EMBL:EXB83831.1, ECO:0000313|Proteomes:UP000030645};
RN [1] {ECO:0000313|Proteomes:UP000030645}
RP NUCLEOTIDE SEQUENCE.
RA He N., Zhao S.;
RT "Draft Genome Sequence of a Mulberry Tree, Morus notabilis C.K. Schneid.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
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DR EMBL; KE344887; EXB83831.1; -; Genomic_DNA.
DR RefSeq; XP_010100669.1; XM_010102367.1.
DR AlphaFoldDB; W9S2B9; -.
DR STRING; 981085.W9S2B9; -.
DR GeneID; 21406199; -.
DR KEGG; mnt:21406199; -.
DR eggNOG; ENOG502QPKZ; Eukaryota.
DR OrthoDB; 930987at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000030645; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF73; 3-KETOACYL-COA SYNTHASE 1; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030645};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..407
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 425..505
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
FT ACT_SITE 262
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 341
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 426
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 430
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 459
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 463
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 534 AA; 60287 MW; 882F62696B206C5E CRC64;
MDSSSNSIDM DKERLTAEMA FKDSSSAVIR IRQRLPDFLQ SVKLKYVKLG YGYSCNPATI
IMTLVLLPLL FSILIQLTGL ELHRVTELWT NQAVRLESID AVTRFAGFSV LLFLFGLYWA
KRSRPVYLVD FACYKPDDER KMSVESFLNM SEESSSFTEE TLQFQRRIST RSGLGDETYF
PRGITSRPPR LSLAEARFEA ESVMFGALDA LFKKTGVEPR EIGILIVNCS LFVPTPSLAS
MIVNHYKLRT DIKSFNLGGM GCSAGLISID LAKDLLRANP NSYAVVVSTE NITQNWYFGN
DRSMLLCNCI FRMGGGAVLL SNRSRDRSRS KYELVHTVRT HKGADDRNYN CVFQREDDKG
TVGVSLAREL MAVAGDALKT NITTLGPLVL PLSEQFLFFV TLIRRKLFNN SKVKPYIPDF
KLAFEHFCIH AGGRAVLDEL QKNLQLSEWH MEPSRMTLHR FGNTSSSSLW YELAYTEAKG
RVGRGDRVWQ IAFGSGFKCN SAVWKALREV PVGEFLGNPW NDCIDRYPVK VPTA
//
