ID W9VJ65_9GAMM Unreviewed; 458 AA.
AC W9VJ65;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Erythronolide synthase, modules 3 and 4 {ECO:0000313|EMBL:EXJ10615.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:EXJ10615.1};
GN Name=eryA {ECO:0000313|EMBL:EXJ10615.1};
GN ORFNames=D791_02446 {ECO:0000313|EMBL:EXJ10615.1};
OS Nitrincola nitratireducens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Nitrincola.
OX NCBI_TaxID=1229521 {ECO:0000313|EMBL:EXJ10615.1, ECO:0000313|Proteomes:UP000019464};
RN [1] {ECO:0000313|Proteomes:UP000019464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK23 {ECO:0000313|Proteomes:UP000019464};
RA Singh A., Pinnaka A.K., Vaidya B.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXJ10615.1, ECO:0000313|Proteomes:UP000019464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK23 {ECO:0000313|EMBL:EXJ10615.1,
RC ECO:0000313|Proteomes:UP000019464};
RX PubMed=26481633; DOI=10.1016/j.syapm.2015.09.002;
RA Singh A., Vaidya B., Tanuku N.R., Pinnaka A.K.;
RT "Nitrincola nitratireducens sp. nov. isolated from a haloalkaline crater
RT lake.";
RL Syst. Appl. Microbiol. 38:555-562(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ10615.1}.
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DR EMBL; AONB01000012; EXJ10615.1; -; Genomic_DNA.
DR AlphaFoldDB; W9VJ65; -.
DR STRING; 1229521.D791_02446; -.
DR PATRIC; fig|1229521.3.peg.2476; -.
DR Proteomes; UP000019464; Unassembled WGS sequence.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049552; PKS_DH_N.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:EXJ10615.1};
KW Transferase {ECO:0000313|EMBL:EXJ10615.1}.
FT DOMAIN 1..228
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
FT DOMAIN 291..439
FT /note="Polyketide synthase dehydratase"
FT /evidence="ECO:0000259|SMART:SM00826"
SQ SEQUENCE 458 AA; 50999 MW; 460CD11E7F8BB775 CRC64;
MTRFLEEQGV VPVAVTGHSV GEVAAAWASG ALPLADAVKV IYFRSAYQGK TAGAGQMTAV
ACSSEDIQQY LDEPRFNAIN LAGINSAKGI TLAGDIEQLT LLEAELKDKG VRLKRLDLDY
AFHSQFMDVI EEGVIEALDS IQPGQTRVPF YSTVTGAELE GSELKADYWW HNIRQPVLFK
PSIDALLEQG NSVFVEIGAH PVLSGYINEG LRTHQRKGLV ISTLSRDDDR LYTLQSAYAK
LLLSGALTNF SQTFPVTGRC VDLPSYPWQR ERFWHPVTSE SMGLLYRHYE HPLLGYRLKH
HPMSWESELD TQRQPWLADH KVGDGVLFPG AGFVELALAA ALSAQARDVL DVEELEILSP
LLLSDQHSKM VRLHLLSDSG QLRVESRERG SDEEWNTHLR GRVIAQSRGL SLAIERLHCL
RVCLILREKP TCKPPAQLVS ITAQLFKRCN PVGSIRIR
//
