ID W9VUV7_9EURO Unreviewed; 650 AA.
AC W9VUV7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=A1O7_08862 {ECO:0000313|EMBL:EXJ55931.1};
OS Cladophialophora yegresii CBS 114405.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ55931.1, ECO:0000313|Proteomes:UP000019473};
RN [1] {ECO:0000313|EMBL:EXJ55931.1, ECO:0000313|Proteomes:UP000019473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ55931.1,
RC ECO:0000313|Proteomes:UP000019473};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ55931.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGW01000006; EXJ55931.1; -; Genomic_DNA.
DR RefSeq; XP_007761041.1; XM_007762851.1.
DR AlphaFoldDB; W9VUV7; -.
DR STRING; 1182544.W9VUV7; -.
DR GeneID; 19183426; -.
DR VEuPathDB; FungiDB:A1O7_08862; -.
DR eggNOG; KOG1625; Eukaryota.
DR HOGENOM; CLU_014923_1_0_1; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000019473; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019473}.
FT DOMAIN 21..254
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 363..589
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 72..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 71531 MW; B24F04D0B99C4B18 CRC64;
MTEVKENLNA RFDPAGNGLA PDILDVLQSV LRVHSLTADE LFIKWEVYCL KMGSEETKLD
LETARLFAKD VQDSVERGER TQQSGPKSAV KQDRKSNVHA TPRTNGKADV FGMLDELTPN
AHPRRNGSIK RKSEFDTPMP RKVSRPDTKK PPGKASKTDG PSGIPFSERQ NAGQTIETLN
EHLSAAEAPI APFSQARLKL VSGTDYKKFE YRPMAMHLSE ASEMLDERID SFLAIVQKAY
NLEDSSFGNA AAQSTSEIVA VGRIACDTAD GKLNAASLVL EMSRRMGAGL RVPLKIDALP
SYQFFPGQIV AMRGTNASGL YFSVKEVLSI PKLPMPSSLP NNIEAINERL EVSEDSTSLP
LNIIVASGPF TAEDNLDFEP FQALCDKAEE SMADALILNG PFLDIEHPML ASGDFEVPDV
HGLNHEASLA ALFRLWISAP LQRLCSAVPS ITIIMIPSVR DALNKHVSWP QARLAKKDLA
LPKQVTMLPN PSFISLNEVV FAVSSQDILY ELSREQLSHG PTADLLTRLP GYLIDQRHFF
PLYPPMSRDK LASNGIVKAT GACLDLGFYK LGEWMQVKPD VLILPSMLTP SIKVVDSVMV
INPGQLSKRK AAGTYSQISL HPRILSEEEK SARTVIHNVF ERARVDVVRI
//
