ID W9VY47_9EURO Unreviewed; 2177 AA.
AC W9VY47;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=A1O7_04751 {ECO:0000313|EMBL:EXJ60598.1};
OS Cladophialophora yegresii CBS 114405.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ60598.1, ECO:0000313|Proteomes:UP000019473};
RN [1] {ECO:0000313|EMBL:EXJ60598.1, ECO:0000313|Proteomes:UP000019473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ60598.1,
RC ECO:0000313|Proteomes:UP000019473};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ60598.1}.
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DR EMBL; AMGW01000003; EXJ60598.1; -; Genomic_DNA.
DR RefSeq; XP_007756951.1; XM_007758761.1.
DR STRING; 1182544.W9VY47; -.
DR GeneID; 19179336; -.
DR VEuPathDB; FungiDB:A1O7_04751; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000019473; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019473};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 366..798
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1659..1736
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1801..1875
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 404..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2177 AA; 235790 MW; 4E80EFEEDF90A50A CRC64;
MEEVYVFGDQ TADCRAFFAK VFSRKDDVLL QAFLERAGDA VRFENKYRSH PSKAVPNFST
IQELVDRYYR GEAKDAAVES ALVCISQFAH FFGAFEERTP SYIPPNTDAR LVGLCTGLIA
ATAVASSDSL TALLPLAVES VRLAFRAGAH VGKVAEQIET DTKAQSWSTI VAADEKSAQA
ALDAFHKEKG TAPTSKLWIS ASSATSITIS GPPATKAALF EHSEFFQSHK NASVSIYAPY
HAAHLHSQAD IEKILRPQTK DIFSNATVRY PVCSSVTGKP ISAKNGYELL QEALKEIIIE
PLRWDKVLKY CASGKAEQAK VFAVGPTNLA SSVVSALKAN TSKVTLEDQS HWSTVAPAGT
QHSKREADIA IVGFSGRFPD AADNELFWQL LEKGLDVHRP VPPDRFPVDS HTDPTSKKKN
TSHTPFGNFI ERPGLFDARF FNMSPREAAQ TDPMQRLVLA TSYEAMEMGG IVPGRTPSTK
HDRIGTFYGQ TSDDWREVNA AQDIDTYFIS GGVRAFGPGR INYFFKFSGP SFSVDTACSS
SFAAMNVAIT SLRANECDTA FTGGANVLTN SDIFSGLSRG HFLSRTGSCK TWDNDADGYC
RGDGVCTVIM KRLDDALADR DPILGVIRGI GTNHSAEAVS ITHPCAENQS FLFDKVLKEC
NVPCNDVNYV EMHGTGTQAG DGIEMESVSS VFAPRQNRRR ADQPLYVGAV KSNIGHGEAV
SGVSALIKVL LMLQKSKIPP HTGIKNQINK NFAPDLKERN VNIAFQTTPF PRPAGGKRTV
FINNFSAAGG NTAMLLQDGP EVPKEPTADP RSTQVVTVSA KSLAAFKRTL TRYEEYLNKN
PNVGLPDLAY TLTARRAHYN YRAAFPVQSV SQLQAALKAI QDQTHNPIPL ASPQIAMAFT
GQGSQYTGMG QKLFETSRQF RGDIEEFNEI ALRQGLPSIM PLIDGSTEVQ HLPPTVVQLG
MCCIQMALTR LWATWGITPS VVIGHSLGEY AALQAAGVLS IADTIYLVGK RAQLLEQKCT
AGTHAMLAVR SPVAGLQDVV ANSEGKIEIA CINGVSDTVL SGTMGDIDTV AQKLADAGQK
CTKLKLPFAF HSSQVDPILA DFEKLASSVK YNPPRVPVIS PLLSDIVSVG GVFDAFYLSR
HCRKTVDFVG GLSAGMSTAT ISDTSLWLEV GGHPLCASMI KSCLSAPTLP TMRRDEDPWK
IISTSMAGLY TAGKTLNWDA FHKENESLRV LNDMPFYGYD EKNYWLQYTG DWLLYKGDYP
KAIAPAAAAP SAPAGPAKAR KYLSTAVQGI VSEEVKGKVA TIIAESDFAH PKLFPVVAGH
LVNGSGLCPS TLYADMAYTL CNYGVNLIKP GEKVDINIGT MDNPAPLLLK NINHPESQIV
RMTMKVDLDG RKADFTVTTN NGRKDVVHAK CVLRFEDAAA WKAEWNKVSY LVQSRIDMLK
HKMENGEADK VSRSMAYKLF GALVDYSDIF QGMQSVVFDG PEFEATSNIK FRAGPNDGDF
YFSPYHIDGA CHLSGFTVNA TVNPMDECFI SHGWGSLKFL APLEHDKQYF AYVKMQPVAG
SKMRVGDVYV FNSQKEVVGV CGAVRFQCIP RKLMDVMMPK PKVAAGAKAA ASVPTPAPVK
ASTPVQAAPQ IEVPAPKVKA KKPVKAPKMK APAAPKAAPS SGSLVVRAFD IIAKEIDVDQ
SELNDDIQWA DMGVDSLMSL TISGKFREDL DLEVESTLFT DYSSVGALRK HLGGMSAPEP
VSAGDASSVE STDSGSESDD ETVESGITTP DTEDFPAKTQ GPTKSAAVEA VAQAPSAAAG
GDMIETIRQV IAQEMEMDLE EITETTDLSN LGMDSLMALT VLGKLREDHE IDLDPTILAD
NPSLGHLRKA LGLDKPKPAP PTAQKHEVVT NVVVAPAAPP VEVVVQMPPA TSVLLQGNPK
TATKNLFLFP DGSGSATSYV SIPAIDSKNL AVYGLNCPFM KDPTSYTCGI EGVSKLYLEE
VMRRQPVGPY ILGGWSAGGV VAYEVTRQLA DLQKQHPDRN YSVEKLILID SPCPIRLEPL
PARLHHFFDE IGLLGTGTGK TPNWLLPHFE YSIKALTAYR PELKTTHDFK APPTLLIWAT
EGVCGKPGDP RPPPQADDPK SMKWLLENRN DFGPNGWDKL LGEEVCKMVT VVGNHFTMMK
PPVAKGVGSF IREALLS
//
