ID W9WB02_9EURO Unreviewed; 1957 AA.
AC W9WB02;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=A1O7_01628 {ECO:0000313|EMBL:EXJ65287.1};
OS Cladophialophora yegresii CBS 114405.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182544 {ECO:0000313|EMBL:EXJ65287.1, ECO:0000313|Proteomes:UP000019473};
RN [1] {ECO:0000313|EMBL:EXJ65287.1, ECO:0000313|Proteomes:UP000019473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114405 {ECO:0000313|EMBL:EXJ65287.1,
RC ECO:0000313|Proteomes:UP000019473};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora yegresii CBS 114405.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ65287.1}.
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DR EMBL; AMGW01000001; EXJ65287.1; -; Genomic_DNA.
DR RefSeq; XP_007753854.1; XM_007755664.1.
DR STRING; 1182544.W9WB02; -.
DR GeneID; 19176239; -.
DR VEuPathDB; FungiDB:A1O7_01628; -.
DR eggNOG; KOG0902; Eukaryota.
DR HOGENOM; CLU_000893_1_0_1; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000019473; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000019473};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1363..1549
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1672..1941
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 470..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1957 AA; 219317 MW; 4089F873969F1ED3 CRC64;
MDVSHGGLRR LAFSKLAALS SVRSSTREAD FKRLTSSLPS PKPQQSGGIL DGVLRSIAPT
SRVPMSHREL DVLLALCASV HDLHDLSHAD RLVKQLAAYL PEFYSQLFLP SPFIQEIRPA
PWTALTYQLT TALLVLGLRF PPLKEAVSAS ITEYVQNWSH SVSALTSLNV GEQDEEQENG
TQEIAAATVS LIGFMNAAAI HENFWTAYER VELVRNLKEA LSERFLIALE TASSAIRNST
SSDAGERDWR KYLRRFAAEG LPVGAMMLQK GFVKLLLACT ARMLCDEHTV QRGDILDQYI
AGTDINRAKD DSITDDMIEY LVDTITEQMR VLEDGSDYLQ LSSVWQQRLA FSVKAYALEA
YLHCLVLDDD IADAEDLAAW LEDSIANQVQ MTDTDLADVV LKSLAVVAKY VPEGANNYAR
ILLRFIVRGT SRPDAVTIAA QSLSHILRML SQDAVITTIY SLGNVLSSQT GAEKTHQPHG
TAESNGHTGS MSSTTRLQTG SVISLSLSGD EETSLVCGNV AHAIVVIATE CNDSKIIALV
QMMMLQKVGR ISVVVDAHIV QEAAKLSIFG KENEFKTLLK LYTRLHHEAV AQNNTPLVEA
VRNAQEYLAL NLDNRSPLFK IYAMQLLERI LSKGDVVEGE FKQSAEVEQA AKEIAPLLKP
LSILASRKPA LTVESTLAED TDILGMAREV WYNVAVHGIT LQSRIGQQHY EELRVLAMNS
MPLVDDDRAE LLESDVEINT VLRRGMNPQH MQAQKKALIS VIPDKESEIG RLSYQKVVFL
NAVFLVESLR ASSGSCAEIL DYFVDPSTQT SHMGACLSSI ANKVVDRYTQ KAVSAKEDDF
SAPYVSRQLA RILSGCCHRS SKMQEIARAA ANHIITFAPS ALCQKSALFA LLELLSLMWS
SCLEADTDEY EWRPTLTSTR GKITVELSDD YAFRRRTEQN LHSDARKWVT MIMGVAPLDV
KGLLQTYLSE FDDTGAYGHI SLGRSFALEM GSMIPPMDYR LNALDHKNES ANINMASDFI
AQYTTRQEYR FTGVPDHQRE NTYIDDATGR RSSMGRVTAD STAILHDVLL DLQKRILQKV
HVRTSEVKDV LRRAAALLCQ SKKSQTAIVH LLVNIPFAIF TKESIKLGIS LWLGVIHENI
RMEPRILTEV AQAWERTIDR GQGIFNPKFK HMDPFYVKEE FAPSDRAALQ KEAQTTHNTI
SPHFRLLQFF ESHFNAIRLA SANTQRTFIR MLERTLRGFL HIHGHPLLRD LQFHVVLFAL
RVLKLGTCLN KLAQWRLKDL ILSVGLRWFA KAPCWSFGGN RLQLKAEIRV MQDVLAQLQA
SRGPILPAST TRKDPQQKQE LLEALLTSEV TRLSVWLSPL VHAGQPAHLD HQIAPLVRVA
WAEDPALAIQ LVSRFTNEQT RRDVRFLLLN QPEKALHEAN AVDLVLGDGL SSDLSFQLKY
LLYWNPVNPI QAVTYFMPAF GNHPFVLQYA MRAVESHSVD VTFFYVPQIV QSLRYDTLGY
VERYIIETGK FSQLFAHQII WNIKANAYKD EDSQIPDPVK PTLDKVMDSL ISSFSGADKD
FFEREFAFFS EVTDISGKLK PFIKKSKPEK KAKIEAELRK IQVDVGVYLP SNPDGVVVGI
DRKSGKPLQS HAKAPYMATF RIRKKKETST EEINGLIESA QQDQTQKNAR KGHSRRNTSD
ISNMELADSN SSTYEVWQSA IFKVGDDCRQ DVLALQMIAA FRGIFNSVGL DVYVFPYRVT
ATAPGCGVID VLPNSISRDM LGREAVNGLH DYFITKYGGE HSVRYQEARS EFVKSMAAYS
VITYLLQFKD RHNGNIMVDD KGHILHIDFG FCFDIAPGGV KFERAPFKLT QEMIAVMGGD
DPATSQPYRW FEELTIKAFL ASRPYCDKLS HLVSLMLDSG LPCFKPETMR NFKNRFVLEK
SERDAADFML GCIKKSAANV TTRVYDEFQL ITNGIPY
//
