ID   W9WNZ1_9EURO            Unreviewed;       234 AA.
AC   W9WNZ1;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE            EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE   AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN   ORFNames=A1O5_10503 {ECO:0000313|EMBL:EXJ66351.1};
OS   Cladophialophora psammophila CBS 110553.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ66351.1, ECO:0000313|Proteomes:UP000019471};
RN   [1] {ECO:0000313|EMBL:EXJ66351.1, ECO:0000313|Proteomes:UP000019471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ66351.1,
RC   ECO:0000313|Proteomes:UP000019471};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC       from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXJ66351.1}.
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DR   EMBL; AMGX01000020; EXJ66351.1; -; Genomic_DNA.
DR   RefSeq; XP_007749269.1; XM_007751079.1.
DR   AlphaFoldDB; W9WNZ1; -.
DR   STRING; 1182543.W9WNZ1; -.
DR   GeneID; 19195196; -.
DR   eggNOG; KOG4003; Eukaryota.
DR   HOGENOM; CLU_068979_13_0_1; -.
DR   OrthoDB; 47357at2759; -.
DR   Proteomes; UP000019471; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd01011; nicotinamidase; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR11080:SF2; LD05707P; 1.
DR   PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019471}.
FT   DOMAIN          6..223
FT                   /note="Isochorismatase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00857"
SQ   SEQUENCE   234 AA;  25324 MW;  0BCCF2BCB2C37614 CRC64;
     MAFRPALIVV DMQNDFCPPD GSLAVSEGRD IVPLINRLLD SPHFVLKVAT QDWHPANHIS
     FAANHPAPNN IPFESFVTVH NLVGNNPNET MQQRLWPIHC VQGTRGAEII PELDVSNVRF
     TVQKGQDSRV EMYSAFSDSF GNLTFGAGGV SHDLAQELAA EHVSHVYVVG LAGDYCVKDT
     ALGSAQAGFT TYVIEEAQRC VDPGTWSDVK GALAQGSVTV VSIDSDEVRR VLGP
//