ID W9X4W1_9EURO Unreviewed; 1074 AA.
AC W9X4W1;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=A1O5_01944 {ECO:0000313|EMBL:EXJ75248.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ75248.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ75248.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ75248.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ75248.1}.
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DR EMBL; AMGX01000002; EXJ75248.1; -; Genomic_DNA.
DR RefSeq; XP_007740750.1; XM_007742560.1.
DR AlphaFoldDB; W9X4W1; -.
DR STRING; 1182543.W9X4W1; -.
DR GeneID; 19186677; -.
DR eggNOG; KOG2024; Eukaryota.
DR HOGENOM; CLU_002346_0_0_1; -.
DR OrthoDB; 276651at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF1; LACTASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471}.
FT DOMAIN 765..1072
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1074 AA; 119478 MW; 2E8CF5F19CE79D59 CRC64;
MLESIDGLGL GGPSVQQQVV QHRPDYANEA VFRRNTLPPR SYWIPKTSLS LNGAWDFHCA
SSPLEAADFD QRQENCWTTI QVPGHWQLQG HGRPQYTNIV YPFPACPPDL PDENPTGTYR
RTFSVPPDWD CSAQLRLRFD GVDSAYHVWL NDDFIGYAQG SRNAAEFDIT AVAKRGKPNK
LLVRVYQWSD GSYIEDQDQW WLSGIFRDVH LLAVPTICRI DDFFIRGDLD ATYKHGALHV
TVDVHSPKGG LVSVVLRERP NHGGETLGSA EASFGGNTTR VDLHIHVDNP NKWTAETPYL
YDVEIILTEG SKSDRVEHTT GFRKVELKNG LLTVNGKVLR FRGVNRHDHH PLFGRAVPLE
FVRQDLLLMK RHNINAVRCS HYPSHPGLYA LADEIGLWVM DEADLECHGF SEVVATNTAE
WDGGEVSYAR WIGAVSKEAR RYLSDNLSWK EAYVDRAVQM VQRDKNHASV IIWSLGNEAF
CGQNHVAMYE ACKRLDPSRL VHYEGDTNMG TTDIYSYMYA AVDALAERAS TRDVAADGTF
TKPVILCEYA HAMGNGPGLL EDYEEVIRAH PRIQGGFVWE WANHGLYQVG PDGKQFYAHG
GDFGQKVHDG TFVMDGLCNS AHEPTPGLIE LKKVYQPVSI HLVNQNLIVE NTYDFVDLGH
LEVTFKVEEF GQSANMLVDG QLKIPPIAAG ARQAVPLPGT VFEQQSKFEL ILTVTFRLGE
AASWAEKRHE VAWFQHQLSP GCRFPVSLPL GSSVPTICNS NSTLTIFTAK STFTFSRARG
LLRSWTTTLG PIIPDSSGYK ESLIPGFWRP PTDNDMPKAL PHWRSFGVDK ITSQLRCMVL
DQKTHSHAFT LTTKTYIAPQ SLGWGWHAIT TYQIQPDGSA VSVFIHLENP VGTVPQHLPR
MGFDLVLAKT LTRVKWFGRG PGESYPDKKS SQRFGVWKGD DISQLQTHYD VPQENGNHMD
TRWLELATGG KGPVVRVSGI DAPCPFGPTA AVQDWASQPH LAPQPVFSFM ATKHSADMLE
KAAHPCDLVE EDVTLLRLDA AVSGVGTGAC GPATRQDHMV KPAGAGFGFI LALK
//
