ID W9X6F3_9EURO Unreviewed; 615 AA.
AC W9X6F3;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=A1O5_10648 {ECO:0000313|EMBL:EXJ66034.1};
OS Cladophialophora psammophila CBS 110553.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=1182543 {ECO:0000313|EMBL:EXJ66034.1, ECO:0000313|Proteomes:UP000019471};
RN [1] {ECO:0000313|EMBL:EXJ66034.1, ECO:0000313|Proteomes:UP000019471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110553 {ECO:0000313|EMBL:EXJ66034.1,
RC ECO:0000313|Proteomes:UP000019471};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora psammophila CBS 110553.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ66034.1}.
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DR EMBL; AMGX01000021; EXJ66034.1; -; Genomic_DNA.
DR RefSeq; XP_007749414.1; XM_007751224.1.
DR AlphaFoldDB; W9X6F3; -.
DR STRING; 1182543.W9X6F3; -.
DR GeneID; 19195341; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_028982_0_0_1; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000019471; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000019471};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 142..254
FT /note="PX"
FT /evidence="ECO:0000259|SMART:SM00312"
FT REGION 1..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 67374 MW; 17246DC27D00FFEF CRC64;
MDYSAAATEA DALHGASPWG SSSPRASRGF PHAAPDSPES PQPIRGHSYN QSQDSIPDSP
YLPPPNQSNV SVPTESGISG DSATAPQNQR PEGGSVQAQA AATQPQDVQT PAAAQQYTGQ
TQQRPGATRY HNARQNRPVP QYKLQAKVTA LERTGRKDPV IRFDVYTNLP KFRTTQFRDV
RRTHSEFVKL ADHLISSNPE ALVPAVPPAQ TSAGVGTDED EARVKAAIQR WLNSVCSNDV
LMRDEEMVFF VESDFGYSPV VRMKQPATGV RRKVLKQFAP PPDDTPELHE ARPVVKTFYL
SSLDTSQKLE KVVKARRALG LAESSLGEKI GQMNVQETHL GLATAYRKLG RIIQTCGDYH
AAQGTAEATT LGDALTYHSS DAFIVKETLT NRHILLRELL QTEASRRSKE NAVQRLKSSS
SVRRDKVDEA ISALDEAMSQ ENYLRSKTQR VTANLLLEKR RWFNRTSNEF MLSLREYVLR
QIEAERRTLA TLESVRPDIR AIDASGGLSR LGRENHPTVR RISMASSQGA KGDAWSGVPR
SRDALSRSMS GSFGPGALGV PLPEESENGT NGAGLAQAGR PRSATGASLE RVKEDEDEDR
VDARNAASRL AQSTF
//
