ID W9XP57_9EURO Unreviewed; 499 AA.
AC W9XP57;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier 1 {ECO:0000256|ARBA:ARBA00021935};
GN ORFNames=A1O1_09158 {ECO:0000313|EMBL:EXJ78756.1};
OS Capronia coronata CBS 617.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182541 {ECO:0000313|EMBL:EXJ78756.1, ECO:0000313|Proteomes:UP000019484};
RN [1] {ECO:0000313|EMBL:EXJ78756.1, ECO:0000313|Proteomes:UP000019484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 617.96 {ECO:0000313|EMBL:EXJ78756.1,
RC ECO:0000313|Proteomes:UP000019484};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia coronata CBS 617.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC pyrophosphate (ThPP) into mitochondria.
CC {ECO:0000256|ARBA:ARBA00002238}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ78756.1}.
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DR EMBL; AMWN01000011; EXJ78756.1; -; Genomic_DNA.
DR RefSeq; XP_007728204.1; XM_007730014.1.
DR AlphaFoldDB; W9XP57; -.
DR STRING; 1182541.W9XP57; -.
DR GeneID; 19164003; -.
DR eggNOG; KOG0032; Eukaryota.
DR eggNOG; KOG0036; Eukaryota.
DR HOGENOM; CLU_015166_2_2_1; -.
DR OrthoDB; 1330359at2759; -.
DR Proteomes; UP000019484; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd15898; EFh_PI-PLC; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF57; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-2; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000019484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT DOMAIN 77..112
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 113..148
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 183..287
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 299..388
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 406..495
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 499 AA; 54811 MW; 44A766F82FB52F9C CRC64;
MNGESHENRD QRIQELWRTL DTRNEGHLDL HGLKKGLRTI DHPLKNADDL LHDVVDAVDT
SGDGRIQYNE FRTFVEHAER ELWQLFQSID KDNSGGLDKN ELRSAFSRAG ITISNAKLDQ
FFDEVDVNHD GQITFDEWRN FLLFLPAGRS SLGAVLSYYS ATGNVNQEGD VTINDTLKGF
DFLPPPGYFI AGGLAGMISR TATAPLDRLK VYLIAQTNPK EAVVEAAKKG APFQAVRHFG
RPLIDACKDL WAAGGMRSLF AGNGLNVIKV MPESAIKFGA YEAAKRALAK FEGSDPKHLR
PTSQFLAGGF GGVISQCLVY PLDTLKFRMQ CDTVAGGLHG NALIFQTART MWKQGGLKPY
YRGLGMGLAG MFPYSAIDLF IFENCKRFVL ARKAKLARCH EDDVDMSNLV TGFIGATSGA
ISATAVYPIN LLRTRLQAQG TILHPPTYTG IWDVAVKTIQ GEGYRGLFKG VTPNLLKVAP
AVSISYVVYE NSKALLGLP
//