ID W9Y646_9EURO Unreviewed; 1050 AA.
AC W9Y646;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=A1O3_09038 {ECO:0000313|EMBL:EXJ77879.1};
OS Capronia epimyces CBS 606.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182542 {ECO:0000313|EMBL:EXJ77879.1, ECO:0000313|Proteomes:UP000019478};
RN [1] {ECO:0000313|EMBL:EXJ77879.1, ECO:0000313|Proteomes:UP000019478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 606.96 {ECO:0000313|EMBL:EXJ77879.1,
RC ECO:0000313|Proteomes:UP000019478};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia epimyces CBS 606.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ77879.1}.
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DR EMBL; AMGY01000009; EXJ77879.1; -; Genomic_DNA.
DR RefSeq; XP_007737324.1; XM_007739134.1.
DR AlphaFoldDB; W9Y646; -.
DR STRING; 1182542.W9Y646; -.
DR GeneID; 19173124; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000019478; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000019478};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..299
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 548..991
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1050 AA; 116244 MW; 1B18B3AE779C4B32 CRC64;
MALSDARDYV LAVESNQHEA AEIARSTAQK LESRQVTLIE VVQSLGEYIN NGDDKIRARA
VSYLVSVISS LPPKYLSRQQ IQVLCHFLCD RIEDGGAIDG LSKLQSLDRF TNEMAQTVVR
AIFEHFADLQ TRNQAGRYRV LQMLNELLDR HRKALRDMGD ESLVGITELV SGEKDPRNLM
LIFSMLRVLM VEWDITMHVE MMFDAVYAYF PITFRPPPND PYGITAQDLK DRLRDCLAAT
PLFAPHTFPN MLDRLDSTSN TVKKDVLQTL AACADNYDPA TISQYSITLW DAVKFEVLQA
QESELAEEAL RVLRSIAECL STHAYSSANS ALLQYLKPIN KECLEHLQEP AARQAKASGN
ILTAVSSASI QAFEIIMKAI GPALITMYQS GQGLVQQRAV LEVSNQLFEA SIDVYGSWTA
LSPKNPQGRE NLMGEFKDQV VAIYSQALMG TVKEEVSFRL TAANGLLLLS KIRGMLSENE
IGLFVQYFDD IVLKEESYGR DELKKRAMAA LAGISHFKPG LISDITFPAF MARLPDAEEA
QPEIYQPVLE GLAEISVEKD LQATLMRRLL NKVEFLFKSS QGTSFPYTCS ILGTILYVLN
RAAAASQSPL DAYYDRVVIG LSRRATETRG GPLTNETVLD ILGRIMNLIV RHSPVDKVQM
AAENIYLLFR NNQLVGDLPT LSTLLEPPTL TILSTWLLAA LPRSIHSVDL DKAQIPRTID
ELILFASKTS SLAITQSCLS QISLYTNKHT KPADLSYVDN LLSQRLLGLR DEPMGDTESI
DFGIRLAFAL TKALILRLSP KTNQYLTSLV DLLDENQHPR EVSRKAAMGF ATILSPDDVL
SKKNAAEIRL LAPQRVFQIL TPLISERFKA SQSPSEKENY LIALSGILAS VPSDIVMPEL
PTLLPLLLQS LDITDQTVKV ATLETLAVVI SNNPSALEES GHIPALVKRL IKVATVPKYK
SPKDASGAGI VPPTNLPTAR RLAARCLALL PKYVGSAGSR ANPLLGLKRE VLHGLTYVLD
DHKRDVRKEA VDARAAWLRG VDDIDDDDDV
//