ID W9YKE1_9EURO Unreviewed; 1387 AA.
AC W9YKE1;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=A1O3_01574 {ECO:0000313|EMBL:EXJ93018.1};
OS Capronia epimyces CBS 606.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182542 {ECO:0000313|EMBL:EXJ93018.1, ECO:0000313|Proteomes:UP000019478};
RN [1] {ECO:0000313|EMBL:EXJ93018.1, ECO:0000313|Proteomes:UP000019478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 606.96 {ECO:0000313|EMBL:EXJ93018.1,
RC ECO:0000313|Proteomes:UP000019478};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia epimyces CBS 606.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ93018.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGY01000001; EXJ93018.1; -; Genomic_DNA.
DR RefSeq; XP_007729908.1; XM_007731718.1.
DR STRING; 1182542.W9YKE1; -.
DR GeneID; 19165708; -.
DR eggNOG; ENOG502QQJC; Eukaryota.
DR HOGENOM; CLU_002210_0_0_1; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000019478; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000019478};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 6..341
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 885..1047
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1059..1375
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 304..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 151773 MW; 68A401FD51B71BFA CRC64;
MTTTLDLPNN YSTNVFTLND FAEIAYIVCT VATPPTQDAV ASSSTPENIL ARLRKTEQQF
REASILAALD VETRQLFTFY KKVDIANAKD QKTLLSKFGY VLRSNTCTIA YKTAARLPDL
IKPEQARLYR LFTTAVVSSI KLLPDGDSAV QPVGPNLYLV ERTASEGMNS FESISKWSLY
RIDLQVIPSG LLVLTIAKDG NLTFLRMLEV TQDSNRLQRL MRDSTAVYLA PVGRIARLAY
RGIESRIALA ADHPGQVLVG DQTLDVWKQL WKELLPPWLK ENMTTATGTE DPGWIEAEIP
VQEVDAESRR SPNSPSSPQS SDEKVIWKPI SWPASLCFVL DSHCTDPVSP TSSDEDPMQF
VQDWLTGTGK QPASTMMAGR SHRDTGEDDD ELLFADEDAF EDSEHFQPFA PPAFPGSQSI
YPTPPDVLMA HPTPGLSSMD GVSMTPANLA RGPSDAVQQY DSEMQDLEDV SGPGGLSGFY
DEDLFEELPD DHFGQEGNGD EPNWDFFDRP GGDNKATPMA TLARGEIFSA RTELPDGAKS
AEDRLANDDI RMRWEHQSDS NKVTAPASTT SWPEGNMEKQ DSTSNTEKRS FPRQLDLENR
SQTSQRSGHP KSRYNVVATH PKGAGPSRRS SMYDGIRPMS TTSDRDNRYM ADGDYWFDPN
PEAPQSSHPS KFATIFQRPS SSSSGSGSSV GSLYPSSALE ASGRKSPDFP RQWTEYQQPP
DVVNSLSEVD RKSAEHEIQH LLTLLKPGFL EVPSITDFGS HDGLHTIPEV GSNELMQIAH
VLVEQISQTS LNTTEMRLSE SPEMPGDLLG VNVDLSGINT STNASSVQQL VHLKVDSNNS
KGQGKIVKLL PSQICVRRAD QPLLASASIL DFWDTLNLQP ESGVKNVTAF CIHPDARNVA
DGCSNLLHRM ADTYSSCALG SHSTGRLPGV TDDGLVIWDQ KGPSRSGLHE TCQRLGSALA
TASSTNDTVI VYMISQDKSA AAYLQACQAF YTLFESFRRG LGDRQDFFDI ALQVIPPDFI
ASPETLVIHP QSTYIKLAIE VYNRLPPSDL SGPPAAAGSA IVLAKADSSV HFRLSPTFTS
PLFKNGPCLH LAYSISVNGR WITAAWTDEL GRVALIMSYC IRLYDPARQR PRQEIFQEMW
EVSHDIMGRV HSSWHLAVVK QGHYEPAEVL EWQQIIDGSS TSRTGCLTLL VSVQLEPVLR
VFPPHAQSKS GQPSLQNTYG TPASTPQASM TSPDQIVAAT PTPGGSSNLN APTPSDPGFD
PNIDGDLTLL DPTEESWGLI LPYGVNQSTN MVDLHPALAT GLLIKRRGPK IEDGCIAIEV
SLIRSSAPAT ATSTESSNDE LLEELIAQYR GLVTLAVTRG CIDPLIECVP WHIAASSRGS
RILGEVL
//