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Database: UniProt
Entry: W9YKE1_9EURO
LinkDB: W9YKE1_9EURO
Original site: W9YKE1_9EURO 
ID   W9YKE1_9EURO            Unreviewed;      1387 AA.
AC   W9YKE1;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE   AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN   ORFNames=A1O3_01574 {ECO:0000313|EMBL:EXJ93018.1};
OS   Capronia epimyces CBS 606.96.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX   NCBI_TaxID=1182542 {ECO:0000313|EMBL:EXJ93018.1, ECO:0000313|Proteomes:UP000019478};
RN   [1] {ECO:0000313|EMBL:EXJ93018.1, ECO:0000313|Proteomes:UP000019478}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 606.96 {ECO:0000313|EMBL:EXJ93018.1,
RC   ECO:0000313|Proteomes:UP000019478};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Capronia epimyces CBS 606.96.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex.
CC       {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC       the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364134}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC       {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EXJ93018.1}.
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DR   EMBL; AMGY01000001; EXJ93018.1; -; Genomic_DNA.
DR   RefSeq; XP_007729908.1; XM_007731718.1.
DR   STRING; 1182542.W9YKE1; -.
DR   GeneID; 19165708; -.
DR   eggNOG; ENOG502QQJC; Eukaryota.
DR   HOGENOM; CLU_002210_0_0_1; -.
DR   OrthoDB; 9289at2759; -.
DR   Proteomes; UP000019478; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009401; Med13_C.
DR   InterPro; IPR021643; Mediator_Med13_N.
DR   InterPro; IPR041285; MID_MedPIWI.
DR   PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR   PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR   Pfam; PF06333; Med13_C; 1.
DR   Pfam; PF11597; Med13_N; 1.
DR   Pfam; PF18296; MID_MedPIWI; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364134};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019478};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364134};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364134}.
FT   DOMAIN          6..341
FT                   /note="Mediator complex subunit Med13 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11597"
FT   DOMAIN          885..1047
FT                   /note="MID"
FT                   /evidence="ECO:0000259|Pfam:PF18296"
FT   DOMAIN          1059..1375
FT                   /note="Mediator complex subunit Med13 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06333"
FT   REGION          304..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1204..1267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..558
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..595
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        675..696
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1207..1255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1387 AA;  151773 MW;  68A401FD51B71BFA CRC64;
     MTTTLDLPNN YSTNVFTLND FAEIAYIVCT VATPPTQDAV ASSSTPENIL ARLRKTEQQF
     REASILAALD VETRQLFTFY KKVDIANAKD QKTLLSKFGY VLRSNTCTIA YKTAARLPDL
     IKPEQARLYR LFTTAVVSSI KLLPDGDSAV QPVGPNLYLV ERTASEGMNS FESISKWSLY
     RIDLQVIPSG LLVLTIAKDG NLTFLRMLEV TQDSNRLQRL MRDSTAVYLA PVGRIARLAY
     RGIESRIALA ADHPGQVLVG DQTLDVWKQL WKELLPPWLK ENMTTATGTE DPGWIEAEIP
     VQEVDAESRR SPNSPSSPQS SDEKVIWKPI SWPASLCFVL DSHCTDPVSP TSSDEDPMQF
     VQDWLTGTGK QPASTMMAGR SHRDTGEDDD ELLFADEDAF EDSEHFQPFA PPAFPGSQSI
     YPTPPDVLMA HPTPGLSSMD GVSMTPANLA RGPSDAVQQY DSEMQDLEDV SGPGGLSGFY
     DEDLFEELPD DHFGQEGNGD EPNWDFFDRP GGDNKATPMA TLARGEIFSA RTELPDGAKS
     AEDRLANDDI RMRWEHQSDS NKVTAPASTT SWPEGNMEKQ DSTSNTEKRS FPRQLDLENR
     SQTSQRSGHP KSRYNVVATH PKGAGPSRRS SMYDGIRPMS TTSDRDNRYM ADGDYWFDPN
     PEAPQSSHPS KFATIFQRPS SSSSGSGSSV GSLYPSSALE ASGRKSPDFP RQWTEYQQPP
     DVVNSLSEVD RKSAEHEIQH LLTLLKPGFL EVPSITDFGS HDGLHTIPEV GSNELMQIAH
     VLVEQISQTS LNTTEMRLSE SPEMPGDLLG VNVDLSGINT STNASSVQQL VHLKVDSNNS
     KGQGKIVKLL PSQICVRRAD QPLLASASIL DFWDTLNLQP ESGVKNVTAF CIHPDARNVA
     DGCSNLLHRM ADTYSSCALG SHSTGRLPGV TDDGLVIWDQ KGPSRSGLHE TCQRLGSALA
     TASSTNDTVI VYMISQDKSA AAYLQACQAF YTLFESFRRG LGDRQDFFDI ALQVIPPDFI
     ASPETLVIHP QSTYIKLAIE VYNRLPPSDL SGPPAAAGSA IVLAKADSSV HFRLSPTFTS
     PLFKNGPCLH LAYSISVNGR WITAAWTDEL GRVALIMSYC IRLYDPARQR PRQEIFQEMW
     EVSHDIMGRV HSSWHLAVVK QGHYEPAEVL EWQQIIDGSS TSRTGCLTLL VSVQLEPVLR
     VFPPHAQSKS GQPSLQNTYG TPASTPQASM TSPDQIVAAT PTPGGSSNLN APTPSDPGFD
     PNIDGDLTLL DPTEESWGLI LPYGVNQSTN MVDLHPALAT GLLIKRRGPK IEDGCIAIEV
     SLIRSSAPAT ATSTESSNDE LLEELIAQYR GLVTLAVTRG CIDPLIECVP WHIAASSRGS
     RILGEVL
//
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