ID W9YN99_9EURO Unreviewed; 1123 AA.
AC W9YN99;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Ca2+:H+ antiporter {ECO:0000313|EMBL:EXJ91160.1};
GN ORFNames=A1O1_04269 {ECO:0000313|EMBL:EXJ91160.1};
OS Capronia coronata CBS 617.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182541 {ECO:0000313|EMBL:EXJ91160.1, ECO:0000313|Proteomes:UP000019484};
RN [1] {ECO:0000313|EMBL:EXJ91160.1, ECO:0000313|Proteomes:UP000019484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 617.96 {ECO:0000313|EMBL:EXJ91160.1,
RC ECO:0000313|Proteomes:UP000019484};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia coronata CBS 617.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ91160.1}.
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DR EMBL; AMWN01000003; EXJ91160.1; -; Genomic_DNA.
DR RefSeq; XP_007723354.1; XM_007725164.1.
DR AlphaFoldDB; W9YN99; -.
DR STRING; 1182541.W9YN99; -.
DR GeneID; 19159153; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_001583_0_0_1; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000019484; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019484};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 245..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 960..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1034..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1065..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..295
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 515..628
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 926..1078
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 124028 MW; 26FB38FCB6E6A0C9 CRC64;
MSSSDTPSVE TAQDGQSQHV DESVARDSTV RKDYGTLSNV PTTSSHRPRS ANRSEDGPEP
PSGMPPLSPQ STRPRKPATI RRTSTRRQLP HRGEQFSVDD DPAEVEEARV PPGPSTPIMP
TPSRQHSTVR RRTHVAVPQL ARVDSAEEEA ERLNLEEPLP APVEEIVEED QEEGLEDSDD
AYLSDAESFT LRDRQLAINE THPFGIRIWK PALYKKNRSV EKGAEEDIHS SPSEIVSKWL
WTFNCLWTIL FGWWLGAAAA VASLVCYLFA FDPSAAAYGT VFWGLAGYLF WPFGKFVKLE
QDENYADEDE GEGRSISEYE RWQSGDLEYG RLMFGPHHTQ SGSIVGRRRN SIDSASETDS
LLGRSGRSDR EDPVIQFKAK RRLFGRGQWT PGRVIFFIFF YFYVAPLMLT VSMICWFMVF
WIPMGRVTLI LFYHLRKRPL SLTFHRDASA ARSSTRPSSI LLCTYRAVGI KYWKYTVDGT
NIFLINFLAV VVFIILDNFI LKQALGLKIW LTSPALMFTL ALISIIPLAY FIGQAVASIS
AQSSMGMGAA VNAFFSTIVE VYLYCIALNE GKGPLVEGSI IGSIFAGILL LPGLSMCFGA
IRRKTQRFNV KSAGATSTML LFAVIAAFGP TLFYKIYGSH ELVCKSCTAS GLDTPRDCRQ
CYFRQVPAIS DEFFVKAVRP YCWIAAGFLF SSYIIGLLFT LRTHAAIIWS TEIEEKKIQL
ANTADVSPMD TRQQSMVNSQ QIHHQNGSYV PRAAIRDSQL YKRILGQSLR SAGLGAEADG
TSEHEPAMGS RVGSQFRGID HQNKHDLPHV VPPKSSHGSD MPQSPALRPV VPGLSEEDNN
NLVRQVAEMA ATAATVAARD AVNHPRAASY QATHSTKTDT VRSSRPAITR SSTVAEEASA
NPAAEQAIHG EGGGHDAPNW SRMKSSVILL TATVAYAIVA EILVDTVDVV LNSIEIDEKF
LGITLFALVP NTTEFLNAIS FAMNGNIALS MEIGLAYALQ VCLLQIPALV LFSAVHGQFI
DPRDLLDHTF NLIFPQWDMV TVILCVFLLS YIAGEGKSNY FKGSILVLTY LVVVFGFYFS
GFTTMTIMGG DPTDTLSIMS SMAWQQSQPR TSQLTGAVGG REL
//
