ID WDR6_BOVIN Reviewed; 1124 AA.
AC A7Z052;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=tRNA (34-2'-O)-methyltransferase regulator WDR6 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 6;
GN Name=WDR6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Together with methyltransferase FTSJ1, methylates the 2'-O-
CC ribose of nucleotides at position 34 of the tRNA anticodon loop of
CC substrate tRNAs (By similarity). Required for the correct positioning
CC of the substrate tRNA for methylation (By similarity). Required to
CC suppress amino acid starvation-induced autophagy (By similarity).
CC Enhances the STK11/LKB1-induced cell growth suppression activity (By
CC similarity). {ECO:0000250|UniProtKB:Q9NNW5}.
CC -!- SUBUNIT: Interacts with FTSJ1; the interaction is direct, and required
CC for 2'-O-methylation of position 34 in substrate tRNAs (By similarity).
CC Interacts with IRS4 (By similarity). Interacts with STK11/LKB1 (By
CC similarity). {ECO:0000250|UniProtKB:Q5XFW6,
CC ECO:0000250|UniProtKB:Q9NNW5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NNW5}.
CC Note=Colocalizes in the cytoplasm with STK11/LKB1.
CC {ECO:0000250|UniProtKB:Q9NNW5}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR6 family. {ECO:0000305}.
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DR EMBL; BC153250; AAI53251.1; -; mRNA.
DR RefSeq; NP_001099093.1; NM_001105623.1.
DR RefSeq; XP_010816041.1; XM_010817739.2.
DR AlphaFoldDB; A7Z052; -.
DR STRING; 9913.ENSBTAP00000025167; -.
DR PaxDb; 9913-ENSBTAP00000025167; -.
DR GeneID; 526884; -.
DR KEGG; bta:526884; -.
DR CTD; 11180; -.
DR eggNOG; KOG0974; Eukaryota.
DR HOGENOM; CLU_002615_0_0_1; -.
DR InParanoid; A7Z052; -.
DR OrthoDB; 1935601at2759; -.
DR TreeFam; TF313984; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030234; F:enzyme regulator activity; ISS:UniProtKB.
DR GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR GO; GO:0002130; P:wobble position ribose methylation; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14344; WD REPEAT PROTEIN; 1.
DR PANTHER; PTHR14344:SF3; WD REPEAT-CONTAINING PROTEIN 6; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 4.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell cycle; Cytoplasm; Reference proteome; Repeat;
KW tRNA processing; WD repeat.
FT CHAIN 1..1124
FT /note="tRNA (34-2'-O)-methyltransferase regulator WDR6"
FT /id="PRO_0000393459"
FT REPEAT 53..97
FT /note="WD 1"
FT REPEAT 105..143
FT /note="WD 2"
FT REPEAT 147..189
FT /note="WD 3"
FT REPEAT 200..238
FT /note="WD 4"
FT REPEAT 247..285
FT /note="WD 5"
FT REPEAT 289..327
FT /note="WD 6"
FT REPEAT 335..376
FT /note="WD 7"
FT REPEAT 381..422
FT /note="WD 8"
FT REPEAT 425..470
FT /note="WD 9"
FT REPEAT 476..520
FT /note="WD 10"
FT REPEAT 557..596
FT /note="WD 11"
FT REPEAT 602..640
FT /note="WD 12"
FT REPEAT 643..682
FT /note="WD 13"
FT REPEAT 743..789
FT /note="WD 14"
FT REPEAT 852..897
FT /note="WD 15"
FT REPEAT 905..950
FT /note="WD 16"
FT REPEAT 974..1015
FT /note="WD 17"
FT REPEAT 1039..1076
FT /note="WD 18"
FT REPEAT 1082..1124
FT /note="WD 19"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NNW5"
SQ SEQUENCE 1124 AA; 122056 MW; B6E3FBF64D6CFCCF CRC64;
MDAHEDYVWP RATSELILLP VTGLECVGER LLAGEGPDVL VYTLDFGGHL RMMKRVQNLL
GHYLIHGFRV RPEPNGDLDS EVMVAAFGSK GLRIVKISWG QGRFRELWRS GLWNMSDWIW
DARWLEGNIA LALGHNSVVL YDPVVGCSLQ DVPCTDRCTL SSACLIGDTW KELTVVAGAV
SNQLLVWYPA AALTDDKPVV PDRRVSGHVG VIFSMSYLES KGLLATASED RSVRIWKVGD
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
IRALAAHERQ AWVITGGDDS GIRLWHLVGR GHPGSGVFAL SFKSHSRPGV LKAVTLAGSW
RVLAVTDAGA LYLYDLEVKC WEQLLEDKRF QSYCLLEAAP GPEGFGLCAL ANGEGRVKVV
PINTPTAAVD LTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE
RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLYPS RPDLLKDLGV VSKVGAITSA
PGAGSGEGEP SLAEWGPMST LPSLHGKQGV TSVTCHGGYV YTTGRDGSYY QLFVRGGQLQ
PVLRQKPCRG MNWVAGVRMV ADGNMVILGF HANEFVVWSP RSHEKLHIIN CGGGHRSWAF
SDTEAAMAFA YLKDGDVMLY RALGGCTRPH VILRESLHGR EITCVKRVGS ITLGPESGVP
SFLQPDHLEP GEPVEPGSEG PGLIDIVITC SEDTTVCVLA LPTATGSAHA LTAVCNHISS
VRAVAVWGVG TPGGPQDPQP GLTAHVVSAG GRAEMHCFTI MVTPDPSPPS RLACHVMHLS
SHRLDEYWDR QRHRHRMIKV DPETRYMSLA VCELDRPGLG PLVAAACSDG AVRLFLLQDS
GRRLQLLAET SHHKRCVLKV HAFTHEAPNR RRRLFLCSAA TDGSLAFWDL TTMLDQDSPA
LEAAADLGLP FQLGSPCLTV QAHSCGVNSL HTLPTREGHL VASGSEDGSL HVFVLAVEMP
ELEEAVGGAE LLPQLQVLEE YSVPCAHAAH VTGLKILSRS LMVSASIDQR LTFWRLGHGE
PTFMNSTVYH VADVADMDCW PVSPEFGHRC ALGGQGLEVY NWYD
//
