ID WF10A_HUMAN Reviewed; 79 AA.
AC Q9H1F0; A2RRE9; Q5TGZ7;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2002, sequence version 2.
DT 24-JAN-2024, entry version 139.
DE RecName: Full=WAP four-disulfide core domain protein 10A;
DE AltName: Full=Putative protease inhibitor WAP10A;
DE Flags: Precursor;
GN Name=WFDC10A; Synonyms=C20orf146, WAP10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AY038182; AAK72469.1; -; mRNA.
DR EMBL; AL031671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75827.1; -; Genomic_DNA.
DR EMBL; BC131579; AAI31580.1; -; mRNA.
DR CCDS; CCDS13363.1; -.
DR RefSeq; NP_542791.1; NM_080753.2.
DR AlphaFoldDB; Q9H1F0; -.
DR SMR; Q9H1F0; -.
DR BioGRID; 126725; 31.
DR IntAct; Q9H1F0; 2.
DR STRING; 9606.ENSP00000361726; -.
DR BioMuta; WFDC10A; -.
DR DMDM; 24212617; -.
DR PaxDb; 9606-ENSP00000361726; -.
DR TopDownProteomics; Q9H1F0; -.
DR DNASU; 140832; -.
DR Ensembl; ENST00000372643.4; ENSP00000361726.3; ENSG00000180305.5.
DR GeneID; 140832; -.
DR KEGG; hsa:140832; -.
DR MANE-Select; ENST00000372643.4; ENSP00000361726.3; NM_080753.3; NP_542791.1.
DR UCSC; uc002xoz.4; human.
DR AGR; HGNC:16139; -.
DR CTD; 140832; -.
DR GeneCards; WFDC10A; -.
DR HGNC; HGNC:16139; WFDC10A.
DR HPA; ENSG00000180305; Tissue enriched (epididymis).
DR neXtProt; NX_Q9H1F0; -.
DR PharmGKB; PA25688; -.
DR VEuPathDB; HostDB:ENSG00000180305; -.
DR eggNOG; ENOG502T9GU; Eukaryota.
DR GeneTree; ENSGT00940000163481; -.
DR HOGENOM; CLU_175686_0_0_1; -.
DR InParanoid; Q9H1F0; -.
DR OMA; IKVCQQR; -.
DR OrthoDB; 5266478at2759; -.
DR PhylomeDB; Q9H1F0; -.
DR TreeFam; TF338513; -.
DR PathwayCommons; Q9H1F0; -.
DR SignaLink; Q9H1F0; -.
DR BioGRID-ORCS; 140832; 10 hits in 1061 CRISPR screens.
DR GenomeRNAi; 140832; -.
DR Pharos; Q9H1F0; Tdark.
DR PRO; PR:Q9H1F0; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H1F0; Protein.
DR Bgee; ENSG00000180305; Expressed in corpus epididymis and 54 other cell types or tissues.
DR Genevisible; Q9H1F0; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; Elafin-like; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR PROSITE; PS51390; WAP; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..79
FT /note="WAP four-disulfide core domain protein 10A"
FT /id="PRO_0000041387"
FT DOMAIN 34..79
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 41..67
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 50..71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 54..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 60..75
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 79 AA; 8943 MW; 2C25A0B258ADFD7F CRC64;
MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC
QANNICCSTY CGNVCMSIL
//
