ID WFDC1_CHICK Reviewed; 222 AA.
AC Q8JG33;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 111.
DE RecName: Full=WAP four-disulfide core domain protein 1;
DE AltName: Full=Protein ps20;
DE Flags: Precursor;
GN Name=WFDC1; Synonyms=PS20;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lopez-Viado C., Galetto R., Piedra E., Ros M., Rodriguez-Rey J.C.;
RT "cps20 is differentially expressed in chicken limb buds.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has growth inhibitory activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AJ438290; CAD27352.1; -; mRNA.
DR RefSeq; NP_989885.1; NM_204554.1.
DR AlphaFoldDB; Q8JG33; -.
DR SMR; Q8JG33; -.
DR STRING; 9031.ENSGALP00000008818; -.
DR PaxDb; 9031-ENSGALP00000008818; -.
DR Ensembl; ENSGALT00000112285; ENSGALP00000091401; ENSGALG00000005503.
DR Ensembl; ENSGALT00010018057.1; ENSGALP00010009943.1; ENSGALG00010007577.1.
DR Ensembl; ENSGALT00015023275; ENSGALP00015013481; ENSGALG00015009574.
DR GeneID; 395238; -.
DR KEGG; gga:395238; -.
DR CTD; 58189; -.
DR VEuPathDB; HostDB:geneid_395238; -.
DR eggNOG; ENOG502QWDC; Eukaryota.
DR GeneTree; ENSGT00390000014299; -.
DR HOGENOM; CLU_108761_0_0_1; -.
DR InParanoid; Q8JG33; -.
DR OMA; RFYKEYP; -.
DR PhylomeDB; Q8JG33; -.
DR TreeFam; TF328768; -.
DR PRO; PR:Q8JG33; -.
DR Proteomes; UP000000539; Chromosome 11.
DR Bgee; ENSGALG00000005503; Expressed in lung and 9 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0061045; P:negative regulation of wound healing; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IBA:GO_Central.
DR Gene3D; 4.10.75.10; Elafin-like; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR042357; WFDC1.
DR PANTHER; PTHR14308; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR14308:SF0; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1; 1.
DR Pfam; PF00095; WAP; 1.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; Elafin-like; 1.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..222
FT /note="WAP four-disulfide core domain protein 1"
FT /id="PRO_0000041368"
FT DOMAIN 61..110
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 68..98
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 80..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 85..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 91..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 222 AA; 25236 MW; CD8B00BD1CED5BEB CRC64;
MDSRMLSDQR FCRRIFAAAL CVLVLLADSG CARNLWKRAL HLKMTEKYDD YEYPLHSHSA
HYQKNDRCPP PPQTLPDRAC EVPSCRSDSE CERHKRCCYN GCIYACLESV QPPPVLDWLV
QPKPRWLGGN GWLLDGPEEV LQAEACSTTE DGDEPLHCPT GYECHIINPG NTAEGIPNRG
QCIKLRGNPD GRNLRHKYYK EYFGSNSNNV VGYVKNQQKH LG
//
