ID X1WCS7_DANRE Unreviewed; 873 AA.
AC X1WCS7; A0A8M1RJ71;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=SH3 and PX domain-containing protein 2A {ECO:0000313|RefSeq:XP_003200390.1};
DE SubName: Full=SH3 and PX domains 2Ab {ECO:0000313|Ensembl:ENSDARP00000128024};
GN Name=sh3pxd2ab {ECO:0000313|Ensembl:ENSDARP00000128024,
GN ECO:0000313|RefSeq:XP_003200390.1,
GN ECO:0000313|ZFIN:ZDB-GENE-101220-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000128024};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000128024, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128024};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000128024}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128024};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_003200390.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_003200390.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU928227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003200390.1; XM_003200342.5.
DR STRING; 7955.ENSDARP00000128024; -.
DR PaxDb; 7955-ENSDARP00000128024; -.
DR Ensembl; ENSDART00000155993; ENSDARP00000128024; ENSDARG00000061758.
DR Ensembl; ENSDART00000155993.2; ENSDARP00000128024.1; ENSDARG00000061758.7.
DR GeneID; 567923; -.
DR KEGG; dre:567923; -.
DR AGR; ZFIN:ZDB-GENE-101220-1; -.
DR CTD; 567923; -.
DR ZFIN; ZDB-GENE-101220-1; sh3pxd2ab.
DR eggNOG; ENOG502QR1V; Eukaryota.
DR HOGENOM; CLU_013051_0_0_1; -.
DR OMA; LDGWWLV; -.
DR OrthoDB; 4095929at2759; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000061758; Expressed in zone of skin and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IBA:GO_Central.
DR GO; GO:0042554; P:superoxide anion generation; IBA:GO_Central.
DR CDD; cd12074; SH3_Tks5_1; 1.
DR CDD; cd12077; SH3_Tks5_2; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035450; SH3PXD2A_SH3_1.
DR InterPro; IPR035452; SH3PXD2A_SH3_2.
DR PANTHER; PTHR15706:SF22; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00018; SH3_1; 4.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 37..96
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 106..165
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 341..400
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 614..673
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 812..873
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 203..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 97112 MW; 3285696C55A1991A CRC64;
MARRSSGGHG RGGSWLTACF FPSSSGKERG EALGAEDCMC VYAVTADYQR QENTEISLKA
GERVEVIEKS ESGWWFVRTA EEQGWVPATY LVSLTGRRDS HRAPNGETEW YITVQPFSSS
SQDELGFESG VIVEVIQRNL EGWWFIRYGG KEGWAPAAYL KKIQDGVTAS NQPAESNKAS
VQGQVEIIGN LMEISNLLNK KPANERHSHT QTDSHSANTY RNSQTDSYTQ YSGDEDQTEV
NTERDSEDQI KTHIETSVSD SSGSVSVSDA CVSAVATELC VSSTVSSFKA KTVPASPAIA
RVAPQRFHSV ENKPPSNNLK PPPRRENSLG FQLPQPPDPP TVEAEYYTIA EFRSCLTDGI
SFSGGQRADV IEKNSGGWWY VQIGEKEGWA PCSYIDKRKK PTLNRQTSTL TRPKVPPPAP
PIKKQNSLPC VESEIMTTTY PRVYEEPEYD VPTIGFEFDP DLDFFPSDAP TKATPPLCQR
TISFTLGDEE DDEGVYANGG FRAVPHCKDN HSPSSAHRAS MWDPPEYDAP TIEPSFETNT
TLYAQSNQPK LKQQADESKS KPSVRPKPTN QDCSSLRKPQ NQEQPSHMQF RTSRTSEESD
TGLSDDFQSC LSDSSSFLYR TTAAYQQEEP CELSFPAGVQ VEVVEKKESG WWFVRWGNEE
GWAPTYYLQP IKSSSETSSP EAKTTEKINS ELSWSASPEL EISVQVDVGK MGKSVSLEKN
EQRVNQSLKG GLRSNSRVGV KQLAVRPQNV LKDNTNAHAA PAGRRNDTLP SHSSLVSYND
QSSSSHAGNT ESMRRKVPVS MVKPKPHLIH NNLREEYVSI ADYRGDAETM SFPAGTRLEV
LERNPNGWWY CRVLDTTKTR KGWVPSNFLE RKS
//
