ID X1WE05_DANRE Unreviewed; 801 AA.
AC X1WE05; A0A8M6Z902;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Pancreatic secretory granule membrane major glycoprotein GP2-like isoform X1 {ECO:0000313|RefSeq:XP_017214057.1};
DE SubName: Full=Si:dkey-239b22.2 {ECO:0000313|Ensembl:ENSDARP00000128456};
GN Name=si:dkey-239b22.2 {ECO:0000313|Ensembl:ENSDARP00000128456,
GN ECO:0000313|RefSeq:XP_017214057.1,
GN ECO:0000313|ZFIN:ZDB-GENE-131120-8};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000128456};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000128456, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128456};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000128456}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128456};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_017214057.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017214057.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR391994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009305162.1; XM_009306887.2.
DR RefSeq; XP_017214057.1; XM_017358568.2.
DR STRING; 7955.ENSDARP00000136979; -.
DR PaxDb; 7955-ENSDARP00000128456; -.
DR Ensembl; ENSDART00000154064.3; ENSDARP00000128456.1; ENSDARG00000097826.3.
DR Ensembl; ENSDART00000169813.2; ENSDARP00000136979.1; ENSDARG00000097826.3.
DR GeneID; 100005128; -.
DR KEGG; dre:100005128; -.
DR AGR; ZFIN:ZDB-GENE-131120-8; -.
DR ZFIN; ZDB-GENE-131120-8; si:dkey-239b22.2.
DR eggNOG; ENOG502QT6B; Eukaryota.
DR HOGENOM; CLU_007211_0_0_1; -.
DR OMA; TENEWCE; -.
DR OrthoDB; 5314208at2759; -.
DR Reactome; R-DRE-446203; Asparagine N-linked glycosylation.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000097826; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:1990266; P:neutrophil migration; IBA:GO_Central.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF11; SI:DKEY-239B22.2-RELATED; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..801
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015102808"
FT TRANSMEM 778..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..741
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 801 AA; 89684 MW; 5F3A81F20CD249CA CRC64;
MIFLISVCAL LPLNIVAFNN ISADPCYNYE PLDRPWRATN ESGSDICEEF FSWSGWYRLF
YNGLDIRMPE SCVSEYSCNA EHSLWLNGPH PKIEDGVVTR DVCGVEGSSC CEYVSLPIKV
KACPGNYYVY EFVKTSLCSG YCIDEKTLSA TTTATVTAIN ISLPAVSNTD DDPCLNYNIL
DDQNRSPNGF FFVYNSIYGY DDTRVQWQGW YRLFINGSNA QMPEWCFSSM SCGGFSSLWL
GGSHPQLDDG VVTRDIYGSY FEVCSYYISD PIQVKACPGN YYVYKLVKPK QLIPAPTYCA
VVMTSPPSVD PCYSYNSLDD PWRASSFLTG DHNNTRCDSD IPLNGWYRLF YNNQSAQMPE
SCVKSGTCGT LYPLWLDGPH PLLEDGVVTR KVCGSQWNDC CGISSHPIQV KACPGNYYVY
EFVRPLYCAA YCADFKQELA FKVTTEELSF TEFLGHCSEL NCTEDERCEE KDGIYGCSCK
RKHQTYKFDF TETCESSHGS ISLSRCQLFD AGFPSDVLHL NDPSCRGTVR DGQVEFYFDN
NEHICGANIV ENGTHIIYDN LILGESGTGP VISRTQFLKI HFQCVYSLEQ TFYMNIDPQG
STVQGIVPAV QETYKVRMIP YKDAEFSQPF GSMVNISLNE QIFVEVYADA VDSLQVASVI
DKCWATPRND SDNSVFWDLI VDKCPNPNSQ VKVLQNGVSI SSRFSFNMSI FTENATEAYL
YCTVHLCSLT NSNCSVDCGS GRIQREIRSV NLQDNSSVSV GPLRIHSNVK DIDAQNQVLV
SMAASLCASL IMIVVSIIIV F
//
