ID X1WFJ7_DANRE Unreviewed; 1619 AA.
AC X1WFJ7; A0A8M1RDU7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=NACHT and WD repeat domain-containing 1 {ECO:0000313|Ensembl:ENSDARP00000129001};
DE SubName: Full=NACHT domain- and WD repeat-containing protein 1 isoform X2 {ECO:0000313|RefSeq:XP_002663751.3};
GN Name=nwd1 {ECO:0000313|Ensembl:ENSDARP00000129001,
GN ECO:0000313|RefSeq:XP_002663751.3,
GN ECO:0000313|ZFIN:ZDB-GENE-071116-8};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129001};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000129001, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129001};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000129001}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129001};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002663751.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_002663751.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; FP016232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002663751.3; XM_002663705.6.
DR STRING; 7955.ENSDARP00000129001; -.
DR PaxDb; 7955-ENSDARP00000129001; -.
DR Ensembl; ENSDART00000156764; ENSDARP00000129001; ENSDARG00000076110.
DR Ensembl; ENSDART00000156764.3; ENSDARP00000129001.2; ENSDARG00000076110.5.
DR GeneID; 100330908; -.
DR KEGG; dre:100330908; -.
DR AGR; ZFIN:ZDB-GENE-071116-8; -.
DR CTD; 284434; -.
DR ZFIN; ZDB-GENE-071116-8; nwd1.
DR eggNOG; KOG3602; Eukaryota.
DR HOGENOM; CLU_004890_1_0_1; -.
DR OMA; YHWSVIE; -.
DR OrthoDB; 2910252at2759; -.
DR Proteomes; UP000000437; Chromosome 11.
DR Bgee; ENSDARG00000076110; Expressed in ovary and 4 other cell types or tissues.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR043365; NWD1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR45013; NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45013:SF1; NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 393..550
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REPEAT 924..965
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 966..997
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1176..1217
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1488..1522
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1619 AA; 181928 MW; D1A5F28ED0BBE476 CRC64;
MDVVEMREAL GLEVLRGQSA DSLQPTSRMV RVFISSTHSD MKNERNAFWE KTYSELQTHC
QSLGLVFEVV DFKCGMRDIT ASDHLITELC IKEIETCQRI SDGPTFIALI GNQYGHRLVP
RLIPEAEFEL LLSKLSKDPE SLKLLNQWFY KDSNSIPPTY ILLPITVHYP HYNERDSENA
QLRDNDVISW NLTESRLLQV LRSAALQAER DGDFTADSKH KFFKSVLEYE MEHGFLRTQR
DASAVLFFRE LPRLSKRDCK KNFAKFLLDV TADGLLDTQA RELLTDLKQR ICNTGRLQPL
CMELSKGAMD PSRKEHKEYL GKLCEQVTSQ LKELISRNAL QTSGTSVDPV WSWLKQEIFH
HAKLSEEKCA VFKGRDDILG KISITLWESN DVSHGPLLVH GPPGVGKTAL LCKLAKEMRA
VVDNRGVVLL RLLGTSLLSS DVDSVLRGVC LQVCGALGLQ SPYSHIAYTH EGLVRFFHSM
LEDVSKQGDT LLLILDSLEQ LLETNKLHKL DWIPKIIPPN VQIVFSTSNE CLDKCKSLVS
AEENIFKLEL LTKDQGRDVI DAYMSAAERK LTAEQQDAIL RYFEQSGNPL HLKLMLDTAK
LWSSYTPMSS VHLDKSAEEV MTQFVESLEV NHGKKLVSHA LSFILLSRYG LSEAELQDVL
SLDNDVLAEI YKCWLPPSHT LMRFPRFHWS RLRHDLSAHL TERWEAGVLL LGFTHRQFAE
LVRRRYLSRD VKADMHTILA EYFSGQWSKG QLRPILLPSL SAFLNADRKV SPQPLWFSEE
LANLRKIHEL PYHLAHAGKW DELRQSVLGS LDWLCCKTLQ CGVSCVIQDL TLCTDLTDCP
EIQLLKETFL LLKPSLDFSD GRVDPSLLVT EIFARLQGLA DHYPSMIGQL CSQCMDWFES
YSDPLLVPKC SFFEAPGGPL KSTLRGFTKG VKAVVLCSKR KLLLAGSEDG LIIVWSLNNL
QPLHTLSGHK AGVLSLKLTD KTNNCLSTGL DGTLRKWCLI SGLQLFCITD AVSVQTHSPT
HIHMNEERKI IITNPSSQVK AWDLDTAEPL FELTAVIGSV LGIVEDEIAC ICSEAILCFY
DISTGTQTSQ TLLPYSAGHH NITCCLTLTK HSKILIAFGE SRLHSVWSHE MESVIDLPSP
ALFLRTSEDE KLLLAGCDRT LCVFLVTLTS MHKVLDLQHD ASILCAVSNS EGSEIITSAQ
DRIIRVWSVT TGALLDWIGV MDSSVSSLAV HQRFIISASV IVNQLKVWQL DHNTTHRNKS
FIPAYCPLAV LSKDGDTVFY VKEGNKTEVF TWSCSEGLQL DSMDVSSEVC CMELAQQKRL
LFCGLHTGTI FIYPLDFIPE TLCLPPPESL PMVRSMAISP REDKMAVAYE DAVCLFEITA
RDSFPCVDGP FERYSLDLLH SSISAMALLS DCRLLYGTFG GEVVIYDFKS ATAAELDHHG
AAITCITMSN WDAQALIGSQ DCVQKLWNLS PVLLNHTMEY KGFYFEGVLC AVFSINDKYV
FTGSLDKTVK VWDVSSGCLL YIQYVYSPVI RMMPHKDGFV AVSQHGSFIK EGFRCPDSLK
PGYNPLRNFQ VHYKVTSRDK SLNVPHSVIN ELPDYNPAQF NFIGIGLIKS KPSNTCVLL
//
