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Database: UniProt
Entry: X1WH66_DANRE
LinkDB: X1WH66_DANRE
Original site: X1WH66_DANRE 
ID   X1WH66_DANRE            Unreviewed;       645 AA.
AC   X1WH66;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 3.
DT   20-JUN-2018, entry version 32.
DE   SubName: Full=Cyclic nucleotide gated channel alpha 1 {ECO:0000313|Ensembl:ENSDARP00000129576};
GN   Name=cnga1b {ECO:0000313|ZFIN:ZDB-GENE-110408-39};
GN   Synonyms=cnga1 {ECO:0000313|ZFIN:ZDB-GENE-110408-39};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129576, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000129576, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129576,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000129576}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129576};
RG   Ensembl;
RL   Submitted (MAR-2014) to UniProtKB.
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DR   EMBL; CR318612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000156842; ENSDARP00000129576; ENSDARG00000012125.
DR   ZFIN; ZDB-GENE-110408-39; cnga1b.
DR   eggNOG; KOG0500; Eukaryota.
DR   eggNOG; ENOG410YWWI; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   OMA; AGNTYYH; -.
DR   Reactome; R-DRE-2485179; Activation of the phototransduction cascade.
DR   Reactome; R-DRE-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR   Proteomes; UP000000437; Chromosome 23.
DR   Bgee; ENSDARG00000012125; -.
DR   ExpressionAtlas; X1WH66; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005221; F:intracellular cyclic nucleotide activated cation channel activity; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR032945; CNGA1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF387; PTHR10217:SF387; 1.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
SQ   SEQUENCE   645 AA;  75173 MW;  90C7DFAD40C062DD CRC64;
     MSSNETISYK CLTLIFSHFF DPIGNLQILN ALQGFFLFFI IFYLSLYPQG GQKEEKERKK
     GEKGCFCYSR KKEKKEKKEK KEKKKEQEEK EKEKEKEKEK EKEKEKEKEK KEPLKEIEVV
     DPAGNMYYNW LFVITCPVMY NWIFIIARSC FEELQGDYLI LWFFLDYLSD AVYLLDMVFR
     TRTGYLEQGL LVKDQKKLRD RYTDSLQFRL DLASMVPTDI FYLYFGMNYP EIRMNKLLRI
     NRLFEFFQRT ETRTNFPNVF RISNLVMYIV IIIHWNACMY YSFSKAIGFG SDAFVYPDPS
     DPEFGRLVRK YAYSMYWSTL TLTTIGETPP PVENSEYFFV VTDFLVGVLI FATIVGNVGS
     MITNANAARA DFQARIDAIK QYMSFRKVTK DLEKRVIKWF DYLWTNKKAV DEREVLKYLP
     DKLRAEIAIN VHLDTLKKVR IFADCEAGLL VELVLKLQPQ VYSPGDYICK KGDIGREMYI
     IKEGKLAVVA DDGITQFVVL SDGSYFGEIS ILNIKGSRAG NRRTANIRSI GYSDLFCLSK
     DDLMEALTEY PDAKAMLEEK GRQILMKDNL LDLELAKQGP DPKDMEEKVQ KIGGVLEDLQ
     TRFARLLAEQ EAAQGKLKKR VTKLEKKMTS ETLMEPPPET ADKTD
//
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