ID X2J8E9_DROME Unreviewed; 3556 AA.
AC X2J8E9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Dachsous, isoform B {ECO:0000313|EMBL:AHN54066.1};
GN Name=ds {ECO:0000313|EMBL:AHN54066.1,
GN ECO:0000313|FlyBase:FBgn0284247};
GN Synonyms=cad2 {ECO:0000313|EMBL:AHN54066.1}, CT39575
GN {ECO:0000313|EMBL:AHN54066.1}, Dachs {ECO:0000313|EMBL:AHN54066.1},
GN dachs {ECO:0000313|EMBL:AHN54066.1}, Dachsous
GN {ECO:0000313|EMBL:AHN54066.1}, Dmel\CG17941
GN {ECO:0000313|EMBL:AHN54066.1}, DS {ECO:0000313|EMBL:AHN54066.1}, Ds
GN {ECO:0000313|EMBL:AHN54066.1}, EP-822 {ECO:0000313|EMBL:AHN54066.1},
GN l(2)01855 {ECO:0000313|EMBL:AHN54066.1}, l(2)05142
GN {ECO:0000313|EMBL:AHN54066.1};
GN ORFNames=CG17941 {ECO:0000313|EMBL:AHN54066.1,
GN ECO:0000313|FlyBase:FBgn0284247}, Dmel_CG17941
GN {ECO:0000313|EMBL:AHN54066.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN54066.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014134; AHN54066.1; -; Genomic_DNA.
DR RefSeq; NP_001285551.1; NM_001298622.1.
DR RefSeq; NP_523446.2; NM_078722.3.
DR SMR; X2J8E9; -.
DR EnsemblMetazoa; FBtr0078045; FBpp0077708; FBgn0284247.
DR EnsemblMetazoa; FBtr0343249; FBpp0309926; FBgn0284247.
DR GeneID; 33245; -.
DR KEGG; dme:Dmel_CG17941; -.
DR AGR; FB:FBgn0284247; -.
DR CTD; 109661; -.
DR FlyBase; FBgn0284247; ds.
DR VEuPathDB; VectorBase:FBgn0284247; -.
DR GeneTree; ENSGT00940000167267; -.
DR HOGENOM; CLU_000265_0_0_1; -.
DR OMA; QPKDYTF; -.
DR OrthoDB; 2961370at2759; -.
DR PhylomeDB; X2J8E9; -.
DR GenomeRNAi; 33245; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0284247; Expressed in wing disc and 20 other cell types or tissues.
DR ExpressionAtlas; X2J8E9; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0045296; F:cadherin binding; IPI:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IDA:FlyBase.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IDA:FlyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:FlyBase.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IDA:FlyBase.
DR GO; GO:0045317; P:equator specification; IMP:FlyBase.
DR GO; GO:0030010; P:establishment of cell polarity; IMP:FlyBase.
DR GO; GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.
DR GO; GO:0042067; P:establishment of ommatidial planar polarity; IMP:FlyBase.
DR GO; GO:0001736; P:establishment of planar polarity; IMP:FlyBase.
DR GO; GO:0048592; P:eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IPI:FlyBase.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0090176; P:microtubule cytoskeleton organization involved in establishment of planar polarity; IMP:FlyBase.
DR GO; GO:0016318; P:ommatidial rotation; TAS:FlyBase.
DR GO; GO:0090175; P:regulation of establishment of planar polarity; IMP:FlyBase.
DR GO; GO:0035159; P:regulation of tube length, open tracheal system; IMP:FlyBase.
DR GO; GO:0035222; P:wing disc pattern formation; IMP:FlyBase.
DR CDD; cd11304; Cadherin_repeat; 26.
DR Gene3D; 2.60.40.60; Cadherins; 27.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24028:SF340; CADHERIN 96CB, ISOFORM D-RELATED; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 23.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 27.
DR SUPFAM; SSF49313; Cadherin-like; 27.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 27.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3097..3119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..174
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 175..286
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 287..393
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 406..504
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 505..611
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 612..715
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 716..827
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 828..931
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 932..1036
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1037..1153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1154..1256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1258..1365
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1366..1485
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1486..1602
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1617..1719
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1720..1847
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1849..1952
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1953..2057
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2058..2164
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2167..2322
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2323..2428
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2428..2532
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2549..2648
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2649..2752
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2754..2862
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2863..2969
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2985..3081
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 2246..2278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3167..3248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3413..3457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3484..3556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3191..3212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3213..3229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3415..3438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3492..3519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3556 AA; 385792 MW; 1F463A767FA85C95 CRC64;
MKATLDSVVA SETMTRVTFT GNHESKDFAI FHRCRRRSNI KSLYSPPALH PSHMLRSSLL
ILLAIVLLGS SQAASHDQER ERKLEVFEGV AVDYQIGYIG DFGGIDSGPP YIIVAEAGVE
TDLAIDRATG EIRTKVKLDR ETRASYSLVA IPLSGRNIRV LVTVKDENDN APTFPQTSMH
IEFPENTPRE VKRTLLPARD LDLEPYNTQR YNIVSGNVND AFRLSSHRER DGVLYLDLQI
SGFLDRETTP GYSLLIEALD GGTPPLRGFM TVNITIQDVN DNQPIFNQSR YFATVPENAT
VGTSVLQVYA SDTDADENGL VEYAINRRQS DKEQMFRIDP RTGAIYINKA LDFETKELHE
LVVVAKDHGE QPLETTAFVS IRVTDVNDNQ PTINVIFLSD DASPKISESA QPGEFVARIS
VHDPDSKTEY ANVNVTLNGG DGHFALTTRD NSIYLVIVHL PLDREIVSNY TLSVVATDKG
TPPLHASKSI FLRITDVNDN PPEFEQDLYH ANVMEVADPG TSVLQVLAHD RDEGLNSALT
YSLAETPETH AQWFQIDPQT GLITTRSHID CETEPVPQLT VVARDGGVPP LSSTATVLVT
IHDVNDNEPI FDQSFYNVSV AENEPVGRCI LKVSASDPDC GVNAMVNYTI GEGFKHLTEF
EVRSASGEIC IAGELDFERR SSYEFPVLAT DRGGLSTTAM IKMQLTDVND NRPVFYPREY
KVSLRESPKA SSQASSTPIV AVVATDPDYG NFGQVSYRIV AGNEAGIFRI DRSTGEIFVV
RPDMLSVRTQ PMHMLNISAT DGGNLRSNAD AVVFLSIIDA MQRPPIFEKA RYNYYVKEDI
PRGTVVGSVI AASGDVAHRS PVRYSIYSGD PDGYFSIETN SGNIRIAKPL DHEAKSQVLL
NIQATLGEPP VYGHTQVNIE VEDVNDNAPE FEASMVRISV PESAELGAPL YAAHAHDKDS
GSSGQVTYSL VKESGKGLFA IDARSGHLIL SQHLDYESSQ RHTLIVTATD GGVPSLSTNL
TILVDVQDVN DNPPVFEKDE YSVNVSESRS INAQIIQVNA SDLDTGNNAR ITYRIVDAGV
DNVTNSISSS DVSQHFGIFP NSGWIYLRAP LDRETRDRYQ LTVLATDNGT PAAHAKTRVI
VRVLDANDND PKFQKSKYEF RIEENLRRGS VVGVVTASDL DLGENAAIRY SLLPINSSFQ
VHPVTGEIST REPLDRELRE LYDLVVEARD QGTPVRSARV PVRIHVSDVN DNAPEIADPQ
EDVVSVREEQ PPGTEVVRVR AVDRDHGQNA SITYSIVKGR DSDGHGLFSI DPTSGVIRTR
VVLDHEERSI YRLGVAASDG GNPPRETVRM LRVEVLDLND NRPTFTSSSL VFRVREDAAL
GHVVGSISPI ERPADVVRNS VEESFEDLRV TYTLNPLTKD LIEAAFDIDR HSGNLVVARL
LDREVQSEFR LEIRALDTTA SNNPQSSAIT VKIEVADVND NAPEWPQDPI DLQVSEATPV
GTIIHNFTAT DADTGTNGDL QYRLIRYFPQ LNESQEQAMS LFRMDSLTGA LSLQAPLDFE
AVQEYLLIVQ ALDQSSNVTE RLQTSVTVRL RILDANDHAP HFVSPNSSGG KTASLFISDA
TRIGEVVAHI VAVDEDSGDN GQLTYEITGG NGEGRFRINS QTGIIELVKS LPPATEDVEK
GGRFNLIIGA KDHGQPEPKK SSLNLHLIVQ GSHNNPPRFL QAVYRATILE NVPSGSFVLQ
VTAKSLHGAE NANLSYEIPA GVANDLFHVD WQRGIITTRG QFDRESQASY VLPVYVRDAN
RQSTLSSSAV RKQRSSDSIG DTSNGQHFDV ATIYITVGDV NDNSPEFRPG SCYGLSVPEN
SEPGVIHTVV ASDLDEGPNA DLIYSITGGN LGNKFSIDSS SGELSARPLD REQHSRYTLQ
IQASDRGQPK SRQGHCNITI FVEDQNDNAP RFKLSKYTGS VQEDAPLGTS VVQISAVDAD
LGVNARLVYS LANETQWQFA IDGQSGLITT VGKLDRELQA SYNFMVLATD GGRYEVRSAT
VPVQINVLDI NDNRPIFERY PYIGQVPALI QPGQTLLKVQ ALDADLGANA EIVYSLNAEN
SAVSAKFRIN PSTGALSASQ SLASESGKLL HLEVVARDKG NPPQSSLGLI ELLIGEAPQG
TPVLRFQNET YRVMLKENSP SGTRLLQVVA LRSDGRRQKV QFSFGAGNED GILSLDSLSG
EIRVNKPHLL DYDRFSTPSM SALSRGRALH YEEEIDESSE EDPNNSTRSQ RALTSSSFAL
TNSQPNEIRV VLVARTADAP FLASYAELVI ELEDENDNSP KFSQKQFVAT VSEGNNKGTF
VAQVHAFDSD AGSNARLRYH IVDGNHDNAF VIEPAFSGIV RTNIVLDREI RDIYKLKIIA
TDEGVPQMTG TATIRVQIVD VNDNQPTFPP NNLVTVSEAT ELGAVITSIS ANDVDTYPAL
TYRLGAESTV DIENMSIFAL DRYSGKLVLK RRLDYELQQE YELDVIASDA AHEARTVLTV
RVNDENDNAP VFLAQQPPAY FAILPAISEI SESLSVDFDL LTVNATDADS EGNNSKVIYI
IEPAQEGFSV HPSNGVVSVN MSRLQPAVSS SGDYFVRIIA KDAGKPALKS STLLRVQAND
NGSGRSQFLQ NQYRAQISEA APLGSVVLQL GQDALDQSLA IIAGNEESAF ELLQSKAIVL
VKPLDRERND LYKLRLVLSH PHGPPLISSL NSSSGISVII TILDANDNFP IFDRSAKYEA
EISELAPLRY SIAQLQAIDA DQENTPNSEV VYDITSGNDE HMFTIDLVTG VLFVNNRLDY
DSGAKSYELI IRACDSHHQR PLCSLQPFRL ELHDENDNEP KFPLTEYVHF LAENEPVGSS
VFRAHASDLD KGPFGQLNYS IGPAPSDESS WKMFRVDSES GLVTSAFVFD YEQRQRYDME
LLASDMGGKK ASVAVRVEIE SRDEFTPQFT ERTYRFVLPA AVALPQGYVV GQVTATDSDS
GPDGRVVYQL SAPHSHFKVN RSSGAVLIKR KLKLDGDGDG NLYMDGRDIS LVISASSGRH
NSLSSMAVVE IALDPLAHPG TNLASAGGSS SGSIGDWAIG LLVAFLLVLC AAAGIFLFIH
MRSRKPRNAV KPHLATDNAG VGNTNSYVDP SAFDTIPIRG SISGGAAGAA SGQFAPPKYD
EIPPFGAHAG SSGAATTSEL SGSEQSGSSG RGSAEDDGED EEIRMINEGP LHHRNGGAGA
GSDDGRISDI SVQNTQEYLA RLGIVDHDPS GAGGGASSMA GSSHPMHLYH DDDATARSDI
TNLIYAKLND VTGAGSEIGS SADDAGTTAG SIGTIGTAIT HGHGVMSSYG EVPVPVPVVV
GGSNVGGSLS SIVHSEEELT GSYNWDYLLD WGPQYQPLAH VFSEIARLKD DTLSEHSGSG
ASSSAKSKHS SSHSSAGAGS VVLKPPPSAP PTHIPPPLLT NVAPRAINLP MRLPPHLSLA
PAHLPRSPIG HEASGSFSTS SAMSPSFSPS LSPLATRSPS ISPLGAGPPT HLPHVSLPRH
GHAPQPSQRG NVGTRM
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