ID X2JEI9_DROME Unreviewed; 2206 AA.
AC X2JEI9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Rho GTPase activating protein at 19D, isoform D {ECO:0000313|EMBL:AHN59966.1};
GN Name=RhoGAP19D {ECO:0000313|EMBL:AHN59966.1,
GN ECO:0000313|FlyBase:FBgn0031118};
GN Synonyms=1412 {ECO:0000313|EMBL:AHN59966.1}, Dmel\CG1412
GN {ECO:0000313|EMBL:AHN59966.1};
GN ORFNames=CG1412 {ECO:0000313|EMBL:AHN59966.1,
GN ECO:0000313|FlyBase:FBgn0031118}, Dmel_CG1412
GN {ECO:0000313|EMBL:AHN59966.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN59966.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014298; AHN59966.1; -; Genomic_DNA.
DR RefSeq; NP_001285496.1; NM_001298567.1.
DR AlphaFoldDB; X2JEI9; -.
DR SMR; X2JEI9; -.
DR STRING; 7227.FBpp0309351; -.
DR DNASU; 33048; -.
DR EnsemblMetazoa; FBtr0340405; FBpp0309351; FBgn0031118.
DR GeneID; 33048; -.
DR AGR; FB:FBgn0031118; -.
DR CTD; 33048; -.
DR FlyBase; FBgn0031118; RhoGAP19D.
DR VEuPathDB; VectorBase:FBgn0031118; -.
DR GeneTree; ENSGT00940000169095; -.
DR InParanoid; X2JEI9; -.
DR OMA; QQHRQVM; -.
DR OrthoDB; 2997116at2759; -.
DR PhylomeDB; X2JEI9; -.
DR BioGRID-ORCS; 33048; 0 hits in 3 CRISPR screens.
DR ChiTaRS; RhoGAP19D; fly.
DR GenomeRNAi; 33048; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0031118; Expressed in second segment of antenna (Drosophila) and 32 other cell types or tissues.
DR ExpressionAtlas; X2JEI9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:0007266; P:Rho protein signal transduction; ISS:FlyBase.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:X2JEI9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 151..208
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1224..1417
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 108..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..1937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2081..2191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1842..1859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2162..2188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2206 AA; 232296 MW; D1E6592A657C7887 CRC64;
MLQNSNGAAA AHSAASAVAT PAAAASAAAA AAAAAVAAAA NNAALAASSI QPKLIVIRRR
PNQGFGFTLR HFIAYPPEDD QASSSASGLV SGSATAATAA SVSTNWPQEA SSAAGSNSGS
SSSVGVAGIT GLEPTSPTSL PPYQVKAMET IFIKEVQANG PAHYANLQTG DRVLMVNNQP
IAGIAYSTIV SMIKQTPAVL TLHVVPKECD VLQMHYTSIA HTPESNRLTM STHSPSLLAN
GSHKTTFPAA AAVAAPPHQH QQQQQQLISY PAVAAVTTST PAGSPQSQSQ SQSHSHPNTH
HAPSLHGGSR SGSITSTASG GITVLSQPFY PQQQQQQQQQ QQHRHPALTG GSSSIDFGDM
AHGLRQHQQQ QQHLYQQQQQ HHQFMRANQP PNLTVLSASS ATNTPTPTAR QPKSATSHNQ
ALYAVGAGPS SAAGSGSGSL SGGSENSDLM IRLRESIKQK EEFLKSPVPA SMSSASSING
NQAQSSSPAQ QQHLQQHQQH FFPSHTPPGG VQVVVPPPRS RHQVMLKQQQ QQQQQHQQHH
VLGYDMYHSG GKLVQRSSTA PGSVCHQHQQ QQQHHLYHQQ QHQQLQQTQH RQVMINNNAK
YAKDLDYFET LQETGVTNKV FERKLVSHMS KGFDPFKPLS INTSALESSA STSSTSATTT
VKKQSVLYES LQQHPLAKYH QTQQQTTTTT TVDGQTSSRM ELHKATLANA TIDPVPVGSS
KFVTLPDKPD KGSSVATLAD IAESSAAAIV DSASGSGNVV RRYKPLSSSS FDEGKPMRRI
SYLRATNNET DFNAEAAAGG DAAATGASGP ASASAASSAP GPTPSSAPAP APAPAPLPIS
IPIPVAAVVE PQKTKSLVEE HPDPTYDVIG GTGGGHEFIE TPNGLEDVRL SAHGSRRASM
SSDMRSSIHI DAELNGKYVP NELEAFETEI EIKSSCINGK RMSEYRSWRQ VKLEIKGDLL
RIYSGRHAKS EHNVIELDIR NFKFFDESMD KKKYLIRMQS KPSPSGAHLA SLGNELNLDE
GHDKLLTSSG SSSANEPAAN AASALTASTS SSTCSSGPYT EILFKTKSSN EMKRLFGLLQ
WKDSLNYDDN EHQPQGKQLA EPQKTVASAS YLDDVQGGAS AADSSPLSSH SGGIADASGS
HHVSALPAAA AIVAATSDSI SPVMKARKSS SHKHIPDKDL GSPKSKNWKD LLFRRGGSGS
GGVSHHDLAS PSACAAKQIG SIGVPLRSCP MSKVNAYVPH LVEVCTNIVE TKGLGVVGIY
RIPGNKAAIS ELSELVNTKD FQFESCASDD RWEDVNVVSS LLKLFIRSLP DALMPASYYI
NFIEADKKFG LERIVLLREI VESLPRHPYE TMKHLIRHLC RVSGNCDVNR MEPKNLAIIF
GPSIIRTPND TLETAVKDMK HQCRIVELLV TQYDYFFEGG SLPDIAEVSG GTAAVSAAQP
QQQTQEDQTS MLLHNLSKIE RITERETTRT SRFMPQLRRK THGKRSAVNS DTYSGESVLV
SGSSSNTTTT TTTTTHTTSS TSSSNTITTT ISTTTIQQRR AQRKAVQSIC DQALILLLPT
PVSSVSLPFQ SLDYAKASAS ASASASSTAS TSSSSTLHSG GKASASSSSS STTKFSSSSS
SACSTTAVAI SSSISATSSK LLSANFKKRS TGGFLGSRSS HQTRKASLDE KDSGQSSGSL
GHSLGVGINL AKEQQRSSVD ISILLTDDDS SSRLSDTGSM SLTTITDTLD SKLRNLRSGS
ESNDENGSPE FPKNRRHTLG QPLHMHSENI PYADESPERL FHQFCNPLET APLSLHLSRS
CTATNTIGGD EKPSKQSGGV APLPPSLLKA AHKLQHSATV PIHQGSSTAP TSGAATPVGT
PTGSGGAGAI PSRSSSSSVT TLTKSIQPRF SNYLSYERGN AAAGGAERVV GSAGGAASDD
DSEGSTTSDP KEKLLLGERP SPSFFIERYN KKRRDHRLFR SASFNCRNYS TRHITAQTSG
GVAAGVSGGV AGAVAVGVAC CQALSTTGLT KDEKTDMNLT KKRQIQNKQN RSIKRRHTVG
GPHDYSASNG GCSNHSHGHD LAAINYNHHN RHHQQQLLKL GSATSGGGGS GAAAAETTTT
TTTTTTVLRR LGTGQAGAEA SVALPASSSG SSSNNNNSPQ SDGSNGNGGG VAGVASNAPP
TGVGVGGNNS SGSSSNSSST STTPAGNGDQ VLEVGIRIKN ISRGRF
//
