ID X2JN42_9CAUD Unreviewed; 289 AA.
AC X2JN42;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=Bcp1_046 {ECO:0000313|EMBL:AHN66523.1};
OS Bacillus phage Bcp1.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Bastillevirinae; Caeruleovirus; Caeruleovirus Bcp1.
OX NCBI_TaxID=584892 {ECO:0000313|EMBL:AHN66523.1, ECO:0000313|Proteomes:UP000019744};
RN [1] {ECO:0000313|EMBL:AHN66523.1, ECO:0000313|Proteomes:UP000019744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24926042;
RA Schuch R., Pelzek A.J., Fazzini M.M., Nelson D.C., Fischetti V.A.;
RT "Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage
RT Bcp1.";
RL Genome Announc. 2:e00334-e00314(2014).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KJ451625; AHN66523.1; -; Genomic_DNA.
DR RefSeq; YP_009031326.1; NC_024137.1.
DR GeneID; 19487252; -.
DR KEGG; vg:19487252; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000019744; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000019744};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..287
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 289 AA; 33023 MW; BA41F6B50AD16623 CRC64;
MINSVDEQYL ELVERVITKG VRKGDRTGTG TMSVFGAQMR FNLAEGFPLL TTKRVPFRIV
AQELLWFVKG STDLKYLLDN NVHIWDDDAY RWYKEHGGEM DKEYFLKNAQ ACGFKLGDIY
GAQWRNWNGD NIDQLKDLIE QVKTNPDSRR MLMIAFNPSV LGKVALPPCH YAVQLYVAEG
KLSLMFTMRS NDIFLGLPFN IASYALLVHI IAKMTGLEVG ELVYSAGDAH VYLNHMEQVK
EQLQREPRLL PKLTVKTVHE NIEDYTIDDF ELEGYDPHPT IKGKVSVGL
//