ID X4QVL6_9ACTO Unreviewed; 853 AA.
AC X4QVL6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=gyrA_2 {ECO:0000313|EMBL:SUO88283.1};
GN ORFNames=B1R42_08010 {ECO:0000313|EMBL:OQD36086.1}, CT171_07525
GN {ECO:0000313|EMBL:PIN51528.1}, NCTC5224_01994
GN {ECO:0000313|EMBL:SUO88283.1};
OS Trueperella pyogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Trueperella.
OX NCBI_TaxID=1661 {ECO:0000313|EMBL:SUO88283.1, ECO:0000313|Proteomes:UP000254485};
RN [1] {ECO:0000313|EMBL:OQD36086.1, ECO:0000313|Proteomes:UP000191477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UFV1 {ECO:0000313|EMBL:OQD36086.1,
RC ECO:0000313|Proteomes:UP000191477};
RA Duarte V.S., Treu L., Campanaro S., Dias R.S., Da Silva C., Giacomini A.,
RA Corich V., De Paula S.O.;
RT "The complete genome sequence of Trueperella pyogenes UFV1 reveals an AI-2
RT transporter and processing system involved in quorum sensing signal-
RT response.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PIN51528.1, ECO:0000313|Proteomes:UP000228715}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bu5 {ECO:0000313|EMBL:PIN51528.1,
RC ECO:0000313|Proteomes:UP000228715};
RA Vaid R.K., Anand T., Riyesh T., Bera B.C., Shanmugasundaram K., Rana N.,
RA Bardwaj S., Batra P., Sharma T., Singha H., Singh R.K., Tripathi B.N.;
RT "First Draft genome sequence of Trueperella pyogenes strain Bu5 isolated
RT from water buffalo in India.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SUO88283.1, ECO:0000313|Proteomes:UP000254485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC5224 {ECO:0000313|EMBL:SUO88283.1,
RC ECO:0000313|Proteomes:UP000254485};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; MVGS01000066; OQD36086.1; -; Genomic_DNA.
DR EMBL; PESV01000003; PIN51528.1; -; Genomic_DNA.
DR EMBL; UHHW01000002; SUO88283.1; -; Genomic_DNA.
DR RefSeq; WP_025296680.1; NZ_UHHW01000002.1.
DR AlphaFoldDB; X4QVL6; -.
DR STRING; 1661.CQ11_07620; -.
DR GeneID; 41087445; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000191477; Unassembled WGS sequence.
DR Proteomes; UP000228715; Unassembled WGS sequence.
DR Proteomes; UP000254485; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SUO88283.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 17..474
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 824..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 94411 MW; 09B2804D08574963 CRC64;
MSENTVSTYD HGHIKDVDLQ REMETSYLDY AMSVIVGRAL PDVRDGMKPV HRRVIYAMWD
GGYRPDSAFS KSVKIVGDVM GNYHPHGDAA IYDTMVRMVQ PWNLRYPLVA GQGNFGTAGD
LGAAAPRYTE ARMAQLAVEM VRDINEDTVD FQPNFDGSVQ EPVVLTSRIP NLLINGSEGI
AVGMATSIPP HNLREVAAGA QWYLEHPDAT RDELLANLML HISGPDFPTG ATILGTKGIE
DMYRTGKGSI TQRAKVEVDE IHGRTCLIVS DLPYQVNPDR LLDRMVEGVK DGRLSGIADI
RDESSGRAGQ RIVVVLKRDA VPKVVLNNLY KHTQLQNNFS ANMLALVDGV PRTLSLDGFI
HHWVQHQVEV ISRRTAFRLR KAEERLMILE GLVKALDMLD EVIALIRRSP TVDEARTGLI
ELLDINEIQA DHILAMQLRR LAALERQKIL DERDEKLALC ADYRDILAKP ERQRAIISEE
LAEVVDKYGD DRRTTILPFD GEMSVEDLIP EEDIVVTVTR SGFIKRTRVC EYRAQRRGGK
GVKGTTLRSD DVVEHMGIAS THDWHLFFTN LGRVYRVKGY EIPEGSRESK GQHVANVLAL
QPGENIAAAF TLRTYDQADY LVLATEDGMV KKTKLSDYDS SRTGGLIAIN LREHVDGSTD
QVVSAQLINE GDELILVSRQ GQSLRFTADD ESLRPMGRAT AGVRGMKFRD GDSLLAMEVI
RENSEVFVIT DGGFAKRTSV DQYRPQNRGG LGIRVAKVVE NRGHLVGALI TQPGDEVVVI
MEGGKVVRSF VDEVNLTGRN TQGVRFVRPD NGDHVLAMAP VFEQETESSA ESADGVVNSA
DGVGNQDNSA QEG
//
