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Database: UniProt
Entry: X4QW95_9ACTO
LinkDB: X4QW95_9ACTO
Original site: X4QW95_9ACTO 
ID   X4QW95_9ACTO            Unreviewed;       281 AA.
AC   X4QW95;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=ATP phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00020998, ECO:0000256|HAMAP-Rule:MF_00079};
DE            Short=ATP-PRT {ECO:0000256|HAMAP-Rule:MF_00079};
DE            Short=ATP-PRTase {ECO:0000256|HAMAP-Rule:MF_00079};
DE            EC=2.4.2.17 {ECO:0000256|ARBA:ARBA00011946, ECO:0000256|HAMAP-Rule:MF_00079};
GN   Name=hisG {ECO:0000256|HAMAP-Rule:MF_00079,
GN   ECO:0000313|EMBL:UVJ60662.1};
GN   ORFNames=B1R42_00575 {ECO:0000313|EMBL:OQD40359.1}, B1R42_00995
GN   {ECO:0000313|EMBL:OQD40066.1}, EBQ10_01270
GN   {ECO:0000313|EMBL:AZR06058.1}, M5C92_04895
GN   {ECO:0000313|EMBL:UVJ60662.1};
OS   Trueperella pyogenes.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Trueperella.
OX   NCBI_TaxID=1661 {ECO:0000313|EMBL:AZR06058.1, ECO:0000313|Proteomes:UP000275951};
RN   [1] {ECO:0000313|EMBL:OQD40066.1, ECO:0000313|Proteomes:UP000191477}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UFV1 {ECO:0000313|EMBL:OQD40066.1,
RC   ECO:0000313|Proteomes:UP000191477};
RA   Duarte V.S., Treu L., Campanaro S., Dias R.S., Da Silva C., Giacomini A.,
RA   Corich V., De Paula S.O.;
RT   "The complete genome sequence of Trueperella pyogenes UFV1 reveals an AI-2
RT   transporter and processing system involved in quorum sensing signal-
RT   response.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AZR06058.1, ECO:0000313|Proteomes:UP000275951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TP4 {ECO:0000313|EMBL:AZR06058.1,
RC   ECO:0000313|Proteomes:UP000275951};
RA   Dong W.;
RT   "Multidrug-resistant genes are associated with an 42-kb island TGI1
RT   carrying a complex class 1 integron in a Trueperella pyogenes.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:UVJ60662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=22/KM0800 {ECO:0000313|EMBL:UVJ60662.1};
RA   Marchionatti E., Perreten V.;
RT   "Complete Genome Sequences of Trueperella pyogenes (tetW) from cattle in
RT   Switzerland.";
RL   Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1-
CC       diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial
CC       role in the pathway because the rate of histidine biosynthesis seems to
CC       be controlled primarily by regulation of HisG enzymatic activity.
CC       {ECO:0000256|ARBA:ARBA00024861, ECO:0000256|HAMAP-Rule:MF_00079}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-
CC         alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017,
CC         ChEBI:CHEBI:73183; EC=2.4.2.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000915, ECO:0000256|HAMAP-
CC         Rule:MF_00079};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00079};
CC   -!- ACTIVITY REGULATION: Feedback inhibited by histidine.
CC       {ECO:0000256|HAMAP-Rule:MF_00079}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC       {ECO:0000256|ARBA:ARBA00004667, ECO:0000256|HAMAP-Rule:MF_00079}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00079}.
CC   -!- SIMILARITY: Belongs to the ATP phosphoribosyltransferase family. Long
CC       subfamily. {ECO:0000256|ARBA:ARBA00007955, ECO:0000256|HAMAP-
CC       Rule:MF_00079}.
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DR   EMBL; CP033905; AZR06058.1; -; Genomic_DNA.
DR   EMBL; MVGS01000004; OQD40066.1; -; Genomic_DNA.
DR   EMBL; MVGS01000003; OQD40359.1; -; Genomic_DNA.
DR   EMBL; CP097247; UVJ60662.1; -; Genomic_DNA.
DR   RefSeq; WP_024964116.1; NZ_RWKU01000001.1.
DR   AlphaFoldDB; X4QW95; -.
DR   STRING; 1661.CQ11_00580; -.
DR   GeneID; 41086138; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000191477; Unassembled WGS sequence.
DR   Proteomes; UP000275951; Chromosome.
DR   Proteomes; UP001058955; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003879; F:ATP phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd13591; PBP2_HisGL1; 1.
DR   Gene3D; 3.30.70.120; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   HAMAP; MF_00079; HisG_Long; 1.
DR   InterPro; IPR020621; ATP-PRT_HisG_long.
DR   InterPro; IPR013820; ATP_PRibTrfase_cat.
DR   InterPro; IPR018198; ATP_PRibTrfase_CS.
DR   InterPro; IPR001348; ATP_PRibTrfase_HisG.
DR   InterPro; IPR013115; HisG_C.
DR   InterPro; IPR011322; N-reg_PII-like_a/b.
DR   InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR   NCBIfam; TIGR00070; hisG; 1.
DR   NCBIfam; TIGR03455; HisG_C-term; 1.
DR   PANTHER; PTHR21403:SF8; ATP PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR21403; ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE; 1.
DR   Pfam; PF01634; HisG; 1.
DR   Pfam; PF08029; HisG_C; 1.
DR   SUPFAM; SSF54913; GlnB-like; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   PROSITE; PS01316; ATP_P_PHORIBOSYLTR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP-
KW   Rule:MF_00079}; ATP-binding {ECO:0000256|HAMAP-Rule:MF_00079};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00079};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP-
KW   Rule:MF_00079};
KW   Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102, ECO:0000256|HAMAP-
KW   Rule:MF_00079}; Magnesium {ECO:0000256|HAMAP-Rule:MF_00079};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00079};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00079};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00079}.
FT   DOMAIN          49..188
FT                   /note="ATP phosphoribosyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01634"
FT   DOMAIN          206..276
FT                   /note="Histidine biosynthesis HisG C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08029"
SQ   SEQUENCE   281 AA;  30852 MW;  447F00DD8BB8FAC6 CRC64;
     MLRIAVPNKG SLSDPASRML AEAGYRQRRE SRELVLVDAE NDVEFFYIRP RDVAVYVGAG
     TVDVGITGRD LLLDSQAPAI EHRGLGFARA TFRFAAPGGE QMSIDDLQGK RIATSYDSLV
     SNYLAKHGID ATVVHLDGAV ESSVRLGVAD AIADVVETGT TLRAAGMAVF GEPLLRSEAI
     LIRRADQEVS HDVQILDGRL EGVIMARNYV LMDYDIQRDL LEHAVRLTPG YQSPTISPLH
     DDEWVAVRAM VERKRMNKVM DDLHDAGARG ILVTPILTSR M
//
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