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Database: UniProt
Entry: X5DXW6_9BACT
LinkDB: X5DXW6_9BACT
Original site: X5DXW6_9BACT 
ID   X5DXW6_9BACT            Unreviewed;       368 AA.
AC   X5DXW6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   26-FEB-2020, entry version 31.
DE   RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase {ECO:0000256|HAMAP-Rule:MF_00033, ECO:0000256|SAAS:SAAS00082867};
DE            EC=2.4.1.227 {ECO:0000256|HAMAP-Rule:MF_00033, ECO:0000256|SAAS:SAAS00082938};
DE   AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase {ECO:0000256|HAMAP-Rule:MF_00033};
GN   Name=murG {ECO:0000256|HAMAP-Rule:MF_00033};
GN   ORFNames=FH5T_11910 {ECO:0000313|EMBL:AHW60075.1}, SAMN05444285_11851
GN   {ECO:0000313|EMBL:SET63170.1};
OS   Draconibacterium orientale.
OC   Bacteria; Bacteroidetes; Bacteroidia; Marinilabiliales; Prolixibacteraceae;
OC   Draconibacterium.
OX   NCBI_TaxID=1168034 {ECO:0000313|EMBL:AHW60075.1, ECO:0000313|Proteomes:UP000023772};
RN   [1] {ECO:0000313|EMBL:AHW60075.1, ECO:0000313|Proteomes:UP000023772}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FH5 {ECO:0000313|EMBL:AHW60075.1,
RC   ECO:0000313|Proteomes:UP000023772};
RA   Li X., Wang X., Xie Z., Du Z., Chen G.;
RT   "Complete genome sequence of a deeply braunched marine Bacteroidia
RT   bacterium Draconibacterium orientale type strain FH5T.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SET63170.1, ECO:0000313|Proteomes:UP000181981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25947 {ECO:0000313|EMBL:SET63170.1,
RC   ECO:0000313|Proteomes:UP000181981};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell wall formation. Catalyzes the transfer of a GlcNAc
CC       subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid
CC       intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-
CC       (pentapeptide)GlcNAc (lipid intermediate II). {ECO:0000256|HAMAP-
CC       Rule:MF_00033, ECO:0000256|SAAS:SAAS00082940}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-
CC         trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-glucosamine =
CC         beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-
CC         diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP;
CC         Xref=Rhea:RHEA:23192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:60032, ChEBI:CHEBI:60033;
CC         EC=2.4.1.227; Evidence={ECO:0000256|HAMAP-Rule:MF_00033,
CC         ECO:0000256|SAAS:SAAS01209325};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00033, ECO:0000256|SAAS:SAAS00082937}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00033};
CC       Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_00033}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 28 family. MurG
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00033,
CC       ECO:0000256|SAAS:SAAS00569248}.
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DR   EMBL; CP007451; AHW60075.1; -; Genomic_DNA.
DR   EMBL; FOHT01000018; SET63170.1; -; Genomic_DNA.
DR   RefSeq; WP_038558555.1; NZ_FOHT01000018.1.
DR   STRING; 1168034.FH5T_11910; -.
DR   EnsemblBacteria; AHW60075; AHW60075; FH5T_11910.
DR   KEGG; dori:FH5T_11910; -.
DR   HOGENOM; CLU_037404_0_1_10; -.
DR   KO; K02563; -.
DR   OrthoDB; 1165736at2; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000023772; Chromosome.
DR   Proteomes; UP000181981; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051991; F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050511; F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0030259; P:lipid glycosylation; IEA:UniProtKB-UniRule.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_00033; MurG; 1.
DR   InterPro; IPR006009; GlcNAc_MurG.
DR   InterPro; IPR007235; Glyco_trans_28_C.
DR   InterPro; IPR004276; GlycoTrans_28_N.
DR   Pfam; PF04101; Glyco_tran_28_C; 1.
DR   Pfam; PF03033; Glyco_transf_28; 1.
DR   TIGRFAMs; TIGR01133; murG; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458215};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458169};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00082922};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458137};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458192};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458141, ECO:0000313|EMBL:AHW60075.1};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00033, ECO:0000256|SAAS:SAAS00458209};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458156};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023772};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00033,
KW   ECO:0000256|SAAS:SAAS00458181, ECO:0000313|EMBL:AHW60075.1}.
FT   DOMAIN          9..146
FT                   /note="Glyco_transf_28"
FT                   /evidence="ECO:0000259|Pfam:PF03033"
FT   DOMAIN          194..357
FT                   /note="Glyco_tran_28_C"
FT                   /evidence="ECO:0000259|Pfam:PF04101"
SQ   SEQUENCE   368 AA;  40543 MW;  3FFE0EA71036D204 CRC64;
     MKQKINRAII SGGGTGGHIF PALAIANEIK KRNPDADILF VGAEDRMEME KVPAAGYKII
     GLPVMGFPRK PSMKMITFFK KLRQSSKLAR KIVADFNPEV AIGVGGYASG PLLRAAAKAK
     VPCLIQEQNS YAGITNKLLS KKVNSICVAY DKMERFFPDE KLIFTGNPVR ENLTEKQNRK
     EAFEFFEVNE SDKVILIVGG SLGARSVNQA VLKNINEIAA SGVQVIWQTG AYYYDKIQED
     LKETKPKNLQ IHKFITRMDL AYEVADLVIS RAGAGTISEL CLVGKASVLV PSPNVSEDHQ
     TKNAMALVEQ DAALMVRDDE INEKLFPLAF EVVKDEARCS ALAAKSKELA KPEATKQIVD
     EVEKLVRQ
//
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