UniProt: X5GWE4

Database: UniProt
Entry: X5GWE4_9RICK

LinkDB:  X5GWE4_9RICK 
Original site:  X5GWE4_9RICK

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
All databases (19)   

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ID   X5GWE4_9RICK            Unreviewed;       437 AA.
AC   X5GWE4;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   13-SEP-2023, entry version 35.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   Name=mgtE {ECO:0000313|EMBL:AHX11382.1};
GN   ORFNames=NHE_0437 {ECO:0000313|EMBL:AHX11382.1};
OS   Neorickettsia helminthoeca str. Oregon.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Neorickettsia.
OX   NCBI_TaxID=1286528 {ECO:0000313|EMBL:AHX11382.1, ECO:0000313|Proteomes:UP000023755};
RN   [1] {ECO:0000313|EMBL:AHX11382.1, ECO:0000313|Proteomes:UP000023755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oregon {ECO:0000313|EMBL:AHX11382.1,
RC   ECO:0000313|Proteomes:UP000023755};
RA   Lin M., Daugherty S.C., Nagaraj S., Cheng Z., Xiong Q., Lin F.-Y.,
RA   Sengamalay N., Ott S., Godinez A., Tallon L.J., Sadzewicz L., Fraser C.M.,
RA   Dunning Hotopp J.C., Rikihisa Y.;
RT   "Sequencing and Comparison of Genomes and Transcriptome Profiles of Human
RT   Ehrlichiosis Agents.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
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DR   EMBL; CP007481; AHX11382.1; -; Genomic_DNA.
DR   RefSeq; WP_038559394.1; NZ_CP007481.1.
DR   AlphaFoldDB; X5GWE4; -.
DR   STRING; 1286528.NHE_0437; -.
DR   KEGG; nhm:NHE_0437; -.
DR   HOGENOM; CLU_037408_1_0_5; -.
DR   OrthoDB; 9790355at2; -.
DR   Proteomes; UP000023755; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023755};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        276..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        304..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        348..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        379..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        413..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          129..191
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          193..249
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   437 AA;  48658 MW;  056EF72735ECE340 CRC64;
     MIETISTILE RLEQVSSEQE KIHAQRELVD AFINAKSETK REFIHQHLSE HPYVLTEISE
     ELINEIIEML GVRQFSKIIT ALPTDEIVDV LENLRQDSIK EIIDLLPSKL NRVIKEILAY
     PEESAGRLIH KDFIVIPKDW SIEQVLQFIR IQKKMPKYLS EIFVVDESNS PIGSVSLNDI
     LCAKSRSLVK SIMQTKIETV GTGQDQEEVA RLFREYSLRS VAVVDEEKKI VGVISIDDVV
     DIISEEAEED ILHAGKVSES DINASVSNTV IHRIKWLIVT FLSINFSSYV IGFFQLTLQQ
     HVELAILMPI TAAMGGNAGI QASTVAVRAI ITKKLAYNNA FRLFLKELLV GLCNGVIMSA
     FMVMIIAMRF HNLALESTFT IAIVLVFTLA TSVGAAIPFI IEKCGGDPAL SSSIITSSFT
     DILAFVVLLS TARIVLG
//

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