ID X6M549_RETFI Unreviewed; 1304 AA.
AC X6M549;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RFI_28632 {ECO:0000313|EMBL:ETO08756.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO08756.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO08756.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO08756.1}.
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DR EMBL; ASPP01024721; ETO08756.1; -; Genomic_DNA.
DR EnsemblProtists; ETO08756; ETO08756; RFI_28632.
DR OrthoDB; 3308050at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR36688; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36688:SF1; ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 462..740
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 956..1096
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1085..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 284..311
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1085..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1304 AA; 151647 MW; DE86E2460B0FC3AC CRC64;
MFVCFKNVFV LRSKIPNITL NICQHKPLLF CSIYRNIQKY VVIADEEEEE EEKGKEGNQL
PFNANAFYLC EFKKELSAAK KISDHIIIGG DWNAHHPAWL DENVDEMGEA VLEFIISNNL
HILNSYPYDC TYYKYNASSS IDVTLCSSSL VGLCNNWRTD EDEFDVHSDH LPITFNIFAQ
WAPQNIKRQK IVTWNLSSNN WEMFRQHLTR NLNVWKNSLI NSQAEISSES PLDRAVKSWS
DYVINAGQAT IGQKTVWKGN KPWWSNKLYK LRKKVHQLKR NFRKNRTSEN YERYKETARS
LKRLLRCEKQ MYITKSIESL HEGNTRQMFC QFRSLNSNKI AIIPSLIIPG KDEEKGSIAE
NDIDKANLLA HCPPEPSNED KEHYEYVEDE ICSVVQMSRE IELNEFFLLH EWYQSEITEE
EVIEAIRHIS AYKSQGPDNI HNLMLKNGGQ SLIDSLVILF GWSYRIGYFP KEWKKSNIVA
IPKPDRDPSI CKNYRPISLL SCVGKLMERI ITMRLMKYLN ENQMLQQNQA GFQSWHNTSE
LLLRLSESIH ASFDKNGVTY AAMLDISAAY DSVWRDGLRY KMRNEFNLRG RLYWWIDSFL
SDRSGKVVLN GTNSSIYEFN TGVPQGSSLS PLLFLLYIND ITQEIYEPIQ CGMFADDVAL
WTSIYTSNVG EMTRQLQLLQ NSLDGIASWA SKWKLLLSSE KSQCITFRNK NKRKYTSMFL
HLRDEKIPET NKVKYLGLIM DTQLSYKEHI NYVYGKAARK LGYLTFLCSY KGIRPSLSVY
NLLYKTIIRP NLEYACAFWN GAPESHKKKL EKIQRIAMCR ILGVMKSTAY DTVNILSQMP
PLELRRQQEE VKLFQRCENH MQNFPNHNLS QAYQLWQSNH NFKPDEYFCW LGKLSTLSRA
CINIELAGLH GIKNTPQIKP LQSIPLKYPT LIPHPTKSPF ARWCEPSSSQ ILTSLDNDCV
IIFTDASTIP NPGFGGVGLV VQDPSMSKWI ELQIPIQGIT TNIGCEIESI KIALEYVLKY
YQDKEYRVVI LNDCKFAVNA IMNRWDAEMY KTQVNTCQKL MLQMEPINIP EIYWIKGHSG
IPGNEKADEV AKRARESAQK NQPELYQRPD KSASFLNADG LNPYFTLMWN RHWTNEGNEK
GQHKHPKTFI RNLMEAQSFE KIVLHRLEVH ERRIICRIIT GKVGLNYYLH KINRADAPEC
KWCSNEVETV AHFLMKCPHY NDIRTEWYAN IVSILPELDE KKFNLKKLVI GDKKWSSEKR
IKIVKELKIS GNEKFKADKD NQSSSKHWPE FQAKTVKVCC DESW
//
