ID X6MA35_RETFI Unreviewed; 391 AA.
AC X6MA35;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE RecName: Full=Pre-mRNA-splicing factor 18 {ECO:0000256|ARBA:ARBA00018242};
GN ORFNames=RFI_26860 {ECO:0000313|EMBL:ETO10516.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO10516.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO10516.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- SIMILARITY: Belongs to the PRP18 family.
CC {ECO:0000256|ARBA:ARBA00008137}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO10516.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ASPP01023428; ETO10516.1; -; Genomic_DNA.
DR AlphaFoldDB; X6MA35; -.
DR EnsemblProtists; ETO10516; ETO10516; RFI_26860.
DR OMA; SFAQVRW; -.
DR OrthoDB; 199348at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.20.940.10; Functional domain of the splicing factor Prp18; 1.
DR Gene3D; 4.10.280.110; Pre-mRNA processing factor 4 domain; 1.
DR InterPro; IPR004098; Prp18.
DR InterPro; IPR014906; PRP4-like.
DR InterPro; IPR036285; PRP4-like_sf.
DR InterPro; IPR039979; PRPF18.
DR PANTHER; PTHR13007; PRE-MRNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR13007:SF19; PRE-MRNA-SPLICING FACTOR 18; 1.
DR Pfam; PF02840; Prp18; 1.
DR Pfam; PF08799; PRP4; 1.
DR SMART; SM00500; SFM; 1.
DR SUPFAM; SSF47938; Functional domain of the splicing factor Prp18; 1.
DR SUPFAM; SSF158230; PRP4-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..174
FT /note="Pre-mRNA processing factor 4 (PRP4)-like"
FT /evidence="ECO:0000259|SMART:SM00500"
FT REGION 36..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 46264 MW; 58B00AAE2ED2B5CB CRC64;
MDILSSRIEE FKKEEKLKNA KRLTLAEKEE IELSVQKRDL EEQKKQKQAK RRQREEKDGY
IVPKKLRRLN DGSNINDQSS TSSNQSTADL SKKSDKIIKV GSFQNKAKKK KFCNRAFLKF
DCRLSEEEVI RRLRQLRQPI RYFGETDEER IVRLRQLELM EDEKQEGASK GLKNEYSHTI
AHEVEKELQE ALAMGGPNKT EKSETHEKKK ESKYDIPMTR NDFEHSEDYV LYFFKRLLRD
WEKSLLQRSE EAKQSVEGKH ETMRQKQTRR DIRPLFKQLK NRTVPIDVLD KSEKIVKAVE
KRDYSLAKTI FLELAIGNAP WPMGVTMVES LLFLFIYFSL FSFCKSCIFH LKKKKDVMND
ETQRKYIHAM ERIISFGQTK YPSEDLTKNV G
//
