ID   X6MCR2_RETFI            Unreviewed;      1905 AA.
AC   X6MCR2;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|Pfam:PF05729};
GN   ORFNames=RFI_26550 {ECO:0000313|EMBL:ETO10825.1};
OS   Reticulomyxa filosa.
OC   Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC   Reticulomyxidae; Reticulomyxa.
OX   NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO10825.1, ECO:0000313|Proteomes:UP000023152};
RN   [1] {ECO:0000313|EMBL:ETO10825.1, ECO:0000313|Proteomes:UP000023152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24332546;
RA   Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA   Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA   Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT   "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL   Curr. Biol. 0:0-0(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETO10825.1}.
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DR   EMBL; ASPP01023090; ETO10825.1; -; Genomic_DNA.
DR   EnsemblProtists; ETO10825; ETO10825; RFI_26550.
DR   OrthoDB; 55870at2759; -.
DR   Proteomes; UP000023152; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12697:SF5; DEOXYHYPUSINE HYDROXYLASE; 1.
DR   PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SMART; SM00248; ANK; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT   DOMAIN          88..198
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|Pfam:PF05729"
FT   REPEAT          1011..1049
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          1484..1516
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   1905 AA;  224613 MW;  7BBCE469119F9E81 CRC64;
     MIHEAITKKL KDYYKSQDKL VPLFDDPEQS IYTCYIRLIL LDQKRFQQRK EQWTNTLDYS
     LICGTGKEKM EVQDIWNVKE SDLEVHHISI CGEAGSGKSV LTQRIAHLWA NDQMWNNQFQ
     WLLHIPFRKI VGIFENNKNK NENNIKDQWL KIMKELNIPQ WNANDTNIVY SKNGLLILDG
     FDEIANELNK KPGIQQWLQY YYSMSLDFNH KIFKAMFMPI FKNISNRYND YHNHAEMLIR
     KLDDNSHLKL LSHTPLYLRL FCYFTRQQII KGQEEEKKEE VQTKSGLDEL NNISISKLYE
     KLLECYMKWN WIKFNGTKDK SNEQDMFNLF KMEMDYLSHI AWEGLKCGQT IISCEIQQKV
     LNIIINKYPR KHISVMSQWS RIYSFGFLQG QESMNPSHPI DSIYFPHLTF QEWFSAYYLV
     NCLYQSNKTK EHQEVCSILM NQQIEPKYSV MIPFMAGILY NNIESGKDSS GSGLLYFWKS
     LYSSPPQLVP IHQMMLCIRY TKSSFLSSQL QDCHNTVIHS FKLWFISWFN FDKDKFAFYE
     SNRIVSRPLD DVIEMYLPTL QYTLIHPDIH LCIISQLIKF KEWVLEIQSD SIFNEEIRDM
     LYLLSFLCIS TETSDIVLQC FESLFSRLEN TDFDHLYEII SMRLKEDQFD SIIKFLKTKL
     PKEKRFTRRE VAYSFRAIAP KLNKRQVSDI FQFLVSGLNR EKNDLLSYAE VLVEIAVKLD
     EKLNDVFKYL TKISIKIPDW PVFRTLLIKT YDGKLKEGVF EYLINGLDNE DRNFSAEVLK
     EISMKLKEEH LNITLQCLKR KFNSKNQDIA SVFENIAIKL NKEQLPIFFQ SLTDGLEDKC
     ERVRYHCAKC LVKLLKKWNQ VQLNNAFKCL MNRLNENTDR IYITSIKKIL MQLNDKNLDI
     AFQYLIDRLD NSKKNVCNIC ANLLAAASTQ WNQTQLNNTF KCLLNISNED FHWTYTYSIE
     KILIQLKGEY LDSAFQCLID RLYNNNRYIR EMCVDLLAAS IQWNKVQLNI LFMNLMKVSK
     DKNKHVRYSC AKSIQKLLLQ LNDEQINNKQ MNNVFIYLIN GFKDKNKNVQ YSCAESLGKI
     ANKLNRIQLN IAFQLMIKKL DDKNEDILVR ISCAESLGRI AMKLSKTQLN DTLKCLMNGL
     NDESENGFVH KYCAYSIEKI LMKLRKIDEN TCISMSFKQL LETILTKFKK KQFNNTLMLL
     FNGLKDENES ISFSYVKELE KFLLKLNGKQ FSTAFDFLVN GLSDENTNAY HLRSDIVNIT
     VLQLNQGQTD RALKYLLDGL NEDIYIYRLC TSALETLESK LNKRQLNKTI KGLLNALNHE
     DCDACYLYMT LLGKLVIKLN EEELYLCTKH CLQIFKENIG VDPILSRTSN NMWQRVIMDM
     LKRDIPGQSE LIAFGLWTYN PCIQFNFNNN IDPNAFNRLL QCCKKQGIEW GFPTEWKWDV
     DDAIPYPCCN NFINTNKTKG SDMSRLKFVL EHHNIDINDV FNEYGYTPLL LAIHYKHWDV
     TRYCIEQGAW IDARGGAFDK VTLQTPVECI VKKIIKEKKN DKMCKWILKQ RTIYPMKQIE
     YAIDYVKDKL IDEDGVSKKI DDTSYETLLV EGATFLLGEN QKGLQEILMN KSLLYWGASR
     NVVLIKPENC KKQRFDKGWH PIPFLAVRIF LLFEMCVELK QKGTNKIKLP KNRTFGQVYE
     KGVRELQVQL TTYWDCLTTE LFEEECPELI DDWVCNVIDR LMNLKPVSKN EFCEMSLVVG
     HEDHCIYLSL CKIFKFILVR IDNRWMETIP SNTHNIENEN KLIQSYLIAY FQSNGSKINK
     NKEWLKDYIK NGIKLRKSKC KKSMKHLYCD NKKLSPPREG NLSLIVKEWP FRPIQIDAQN
     CYLRNHNIGY RIRVGDVLYK WFRDQECKSF VFSRSNYNKA IVVEK
//