ID X6MF37_RETFI Unreviewed; 346 AA.
AC X6MF37;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=Chloride channel protein 2 {ECO:0000313|EMBL:ETO12494.1};
DE Flags: Fragment;
GN ORFNames=RFI_24882 {ECO:0000313|EMBL:ETO12494.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO12494.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO12494.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO12494.1}.
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DR EMBL; ASPP01021362; ETO12494.1; -; Genomic_DNA.
DR AlphaFoldDB; X6MF37; -.
DR EnsemblProtists; ETO12494; ETO12494; RFI_24882.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF10; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 90..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 281..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETO12494.1"
FT NON_TER 346
FT /evidence="ECO:0000313|EMBL:ETO12494.1"
SQ SEQUENCE 346 AA; 37568 MW; 4B746C7FEEEAC052 CRC64;
LLGAGCAGAL GAVFGAPIGG VLFSIEVTST YYPVTNYWTA FCCGISASTF IKVLNRSVAH
ISLFRDFVGD NSTKFSKEGH DTFKSNELPL FLLLGLIFGL IGLFVVKFNA WVVAFRRKHQ
AKYLGNWADG NLISNLAWTT IIWMVFLPIV QTLQFPAGVV GPSYILGAFG GRFFGEVFRS
FLEESGLGTV DARVYAVVGA AASLGSITKT ISPAVIVMEI TNELTLSVPL LLAVIVGCGV
VSAFGEGFFD SGLKLRGIPM LPIVPSQQYK VVTETTVLKT NQDKDKDKEK EKTEIDPEAR
LSPNRSESAL KPVQYTVLRF ITATDVMEKT TFITVRPRPS ELVEAL
//
