ID X6NL59_RETFI Unreviewed; 313 AA.
AC X6NL59;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Malate dehydrogenase, cytosolic {ECO:0000313|EMBL:ETO27020.1};
GN ORFNames=RFI_10114 {ECO:0000313|EMBL:ETO27020.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO27020.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO27020.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO27020.1}.
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DR EMBL; ASPP01007509; ETO27020.1; -; Genomic_DNA.
DR AlphaFoldDB; X6NL59; -.
DR EnsemblProtists; ETO27020; ETO27020; RFI_10114.
DR OMA; GMIGSNM; -.
DR OrthoDB; 501358at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF0; MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003369};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 16..103
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 107..258
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 313 AA; 35259 MW; 7842D996961CEABD CRC64;
MKEKKQRGGG REQLKKKMII IMNIDYAVLV GGFPRQAGME RKQLMEKNSP IFKAMGEGLE
KYAKKTCKVK HSTEHFVLVV ANPVNTNALV CAHYAPKIPK KNFVALTRLD QNRGLAQLAE
KLSVPVAHVR NVVIWGNHSS TQFLFYFLFA ILVPDVSDAQ VLTNGKYEKV KVDAQWVRGD
FTKIVQQRGK AIIDARGMSS AMSAANAIKD CLRDWAQGTH EGEHVSMGVF TDGSYGITDE
LIFSFPCVCK NGDYHIVTVS FYLFFLCLEL CPRFFICIGL KFYQGQKLDE ETEKLLKATH
KELLEEKVEA GLK
//
