ID X6PE59_RETFI Unreviewed; 706 AA.
AC X6PE59;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=RasGEF domain-containing protein {ECO:0000313|EMBL:ETO36795.1};
GN ORFNames=RFI_00270 {ECO:0000313|EMBL:ETO36795.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO36795.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO36795.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO36795.1}.
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DR EMBL; ASPP01000287; ETO36795.1; -; Genomic_DNA.
DR AlphaFoldDB; X6PE59; -.
DR EnsemblProtists; ETO36795; ETO36795; RFI_00270.
DR OrthoDB; 5482678at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 158..322
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 375..633
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 30..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 81666 MW; E0883FF8B3BB67B4 CRC64;
MTILCSARSV DMRWNRSRCL LPIFVRTNSS RPNKSKKKKA TPRKETINAR PGPRERSFTD
AIPANDIAIS ASGTVKQSAI ASKTFQFTAP SESNTPEHTV ESKDNTAVVI VPLDGESDSV
VKNKNVEWTV PDLTEPSITI TPSHSQAETE TLKFEDDLEA EQDRFQVSEL IWGLTHEDNK
DDSVKDVLLL CHQSFSTSMH LWQCLAKRFL HRNWSRASMS FSLSTNEDPS FYAGPDVNGS
NTMSPRTGQK ESKLVGMDAL WPVQVKVTNL LQHWMRLYWN EDFATQPDLV RSVLKFIELV
DYNLDNDQRF DDATRKKTRK LLAMVQQTIE TQDKQFQKKT QERESKVIFS KQKSVKMLGM
DQEAEEFAQD FIKVDNQKIA EQLTLLDFEI FKQIKPRECI GQAWKKENKI QVAPNICKFI
DQFNRISKYI QASILNAPDA KKRGRLIKKF LKLSNVLYIL LKDTQNNIKN NVYKHYIYEL
FTLHNFQSLC AVHGALTSVP IHKLKTAWKF VPNKHLARFE ELKVIFRTAH NMSNLRKIHR
EACAPMIPYT GIFLSDLVSI EEGTRQRKDD GTVNFSKLIR LNSQIENSLL YQKTLYSHAK
HPSLYNFLEK VLQSQDQIKV EELYNLATEV AKQDAKANHK RRFFGHSTEN FENVVFGFCC
LFVGFLCSMD SWHDFRLRAI TYFEKIISLC SSIYRKRIGF LQENFF
//
