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Database: UniProt
Entry: X7E2G6_9GAMM
LinkDB: X7E2G6_9GAMM
Original site: X7E2G6_9GAMM 
ID   X7E2G6_9GAMM            Unreviewed;       433 AA.
AC   X7E2G6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   10-APR-2019, entry version 21.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=MUS1_03640 {ECO:0000313|EMBL:ETX10152.1};
OS   Marinomonas ushuaiensis DSM 15871.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=1122207 {ECO:0000313|EMBL:ETX10152.1, ECO:0000313|Proteomes:UP000054058};
RN   [1] {ECO:0000313|EMBL:ETX10152.1, ECO:0000313|Proteomes:UP000054058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15871 {ECO:0000313|EMBL:ETX10152.1,
RC   ECO:0000313|Proteomes:UP000054058};
RA   Lai Q., Shao Z.S.;
RT   "Marinomonas ushuaiensis DSM 15871 Genome Sequencing.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETX10152.1}.
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DR   EMBL; JAMB01000010; ETX10152.1; -; Genomic_DNA.
DR   RefSeq; WP_036162668.1; NZ_JAMB01000010.1.
DR   STRING; 1122207.MUS1_03640; -.
DR   EnsemblBacteria; ETX10152; ETX10152; MUS1_03640.
DR   PATRIC; fig|1122207.3.peg.2349; -.
DR   OrthoDB; 1464088at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000054058; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054058};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:ETX10152.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054058};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      353    429       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       9     16       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    203    203       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     103    103       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     188    188       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   433 AA;  46313 MW;  752225A0B8737421 CRC64;
     MKPVKVGICG LGTVGSGSFN ILRNNAEEIT RRVGRSIVIE QIGARRDNDM CDTTGMNVTR
     DIFDVVNNPE IDIVLELIGG TSVAKELVLT AIANGKHVVT ANKALIAEHG NEIFARAQEQ
     GVIVAFEAAV AGGIPIIKTL REGLSANRID WLAGIINGTG NFILSEMSEK QRDFDDVLAE
     AQELGYAEAD PTFDVEGIDA AHKLTILASI AFGIPLQFER TYTEGISRIT AEDVAFADDL
     GYAIKHLGIA RRSKTGIELR VHPTLISHKQ LLANVNGVMN AIMVQGDVVG PTLTYGAGAG
     ALPTGSSVIA DVIDVARTLT ADPTNRVPHL AFQADALSAV QILPVEEIEC GFFLNMTIKD
     RAGVLANITQ ILSNNDISIE SLIQREREGS ELVPLVVMTH DVKERNMNAA IAAIEALPDV
     AGTVQRIRVE NLA
//
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