ID   X7E8K0_9GAMM            Unreviewed;       785 AA.
AC   X7E8K0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=MUS1_09280 {ECO:0000313|EMBL:ETX11468.1};
OS   Marinomonas ushuaiensis DSM 15871.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Marinomonas.
OX   NCBI_TaxID=1122207 {ECO:0000313|EMBL:ETX11468.1, ECO:0000313|Proteomes:UP000054058};
RN   [1] {ECO:0000313|EMBL:ETX11468.1, ECO:0000313|Proteomes:UP000054058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15871 {ECO:0000313|EMBL:ETX11468.1,
RC   ECO:0000313|Proteomes:UP000054058};
RA   Lai Q., Shao Z.S.;
RT   "Marinomonas ushuaiensis DSM 15871 Genome Sequencing.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETX11468.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JAMB01000003; ETX11468.1; -; Genomic_DNA.
DR   RefSeq; WP_036159799.1; NZ_JAMB01000003.1.
DR   AlphaFoldDB; X7E8K0; -.
DR   STRING; 1122207.MUS1_09280; -.
DR   PATRIC; fig|1122207.3.peg.1000; -.
DR   eggNOG; COG0417; Bacteria.
DR   OrthoDB; 5807460at2; -.
DR   Proteomes; UP000054058; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05784; DNA_polB_II_exo; 1.
DR   Gene3D; 2.40.50.590; -; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054058};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          66..291
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          372..756
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   COILED          470..497
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   785 AA;  89766 MW;  DDB63D75DF718898 CRC64;
     MFVEKHGYII SRHTREVGGQ IEMSLFIKTP EGTVKVLPDK QLSVFFTDAP LDSLPNDVTG
     VQCTESQLRS FDNTPVTIVQ SHSLTIHQQM VSLVKRNGFA VFEGDIKAHN RYLMERNIRG
     SVRFIGVPDS ANQIYRQAKV IAGDWQPEWK VWSLDIETSV STNTLLSIGI TAKDQRIAFV
     VTKNPIDTDI VYAFSDEKNL LLAFIRYVRT HSPDIFIGWN LIGFDLQFID QRCQVLGIRP
     AFGVNGENWN IRSSDNQGRY FASIPGRVAL DGITLLKVGG YHFESYSLNN VSKEILDDGK
     LLQGGDRWQE IERLHREDLD AFVAYNLQDC DLVLRIFEKL KLIQLQQTRV DLTGIPLEQP
     GGSVAAFENL YLPRLHKAGW VAPAWTEDDF VASPGGFVMS SIPGLYKNVL VFDFKSLYPS
     IIRTFYIDPL ARVSARHEST RHEEQKSKTI KSRLIPGFLG ANFDRNKAIL PELIAELAQA
     REEAKRTNND ILSYAIKIIM NSFYGVLGSN VCRFYHAELA SSITMRGHEL LARAKDWIEE
     RGAKVIYGDT DSLFVTLNDA QIDPQLFGEQ LCTEINHCLQ VWCNDYAQLE SRLELEFEQV
     YDRFFMPTIR GQEEGSKKRY AGRSKGKLIF KGLEAARSDW TPLARQFQRT LFEKIFNDEN
     PIPYIQETIE KLRAGLYDEL LVYSKQLSRP LSSYTKNKPP HVRAAAIIDQ KRAEFGQPLE
     YDKGRKRVYY LYQITGVIPY ETTDDLVNLD YEHYIEKQIE PIAESILPFF HTNMESLLSQ
     QISLL
//