ID   X7EKW3_9RHOB            Unreviewed;       603 AA.
AC   X7EKW3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Probable branched-chain-amino-acid aminotransferase {ECO:0000256|ARBA:ARBA00014472};
DE            EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN   ORFNames=OCH239_11520 {ECO:0000313|EMBL:ETX15806.1};
OS   Roseivivax halodurans JCM 10272.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseivivax.
OX   NCBI_TaxID=1449350 {ECO:0000313|EMBL:ETX15806.1, ECO:0000313|Proteomes:UP000022447};
RN   [1] {ECO:0000313|EMBL:ETX15806.1, ECO:0000313|Proteomes:UP000022447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10272 {ECO:0000313|EMBL:ETX15806.1,
RC   ECO:0000313|Proteomes:UP000022447};
RA   Lai Q., Li G., Shao Z.;
RT   "Roseivivax halodurans JCM 10272 Genome Sequencing.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00001419};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETX15806.1}.
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DR   EMBL; JALZ01000003; ETX15806.1; -; Genomic_DNA.
DR   AlphaFoldDB; X7EKW3; -.
DR   STRING; 1449350.OCH239_11520; -.
DR   PATRIC; fig|1449350.3.peg.916; -.
DR   eggNOG; COG0115; Bacteria.
DR   eggNOG; COG0284; Bacteria.
DR   OrthoDB; 9805628at2; -.
DR   UniPathway; UPA00070; UER00120.
DR   Proteomes; UP000022447; Unassembled WGS sequence.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046394; P:carboxylic acid biosynthetic process; IEA:UniProt.
DR   CDD; cd04725; OMP_decarboxylase_like; 1.
DR   Gene3D; 3.30.470.10; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.20.10.10; D-amino Acid Aminotransferase, subunit A, domain 2; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001544; Aminotrans_IV.
DR   InterPro; IPR036038; Aminotransferase-like.
DR   InterPro; IPR043132; BCAT-like_C.
DR   InterPro; IPR043131; BCAT-like_N.
DR   InterPro; IPR011995; OMPdecase_type-2.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; TIGR02127; pyrF_sub2; 1.
DR   PANTHER; PTHR42743; AMINO-ACID AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR42743:SF20; BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF01063; Aminotran_4; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF56752; D-aminoacid aminotransferase-like PLP-dependent enzymes; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   4: Predicted;
KW   Aminotransferase {ECO:0000313|EMBL:ETX15806.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000022447};
KW   Transferase {ECO:0000313|EMBL:ETX15806.1}.
FT   DOMAIN          340..589
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|SMART:SM00934"
SQ   SEQUENCE   603 AA;  62971 MW;  D1AE939E33FA8EBA CRC64;
     MTQAQKSHST HSATEDARNR DILIWVNGRL LHRSAAKVSV YDAGFLLGDG IWEGLRLHDG
     EWAFLGDHLD RFFEGCRAIG MDPGIDRAGL KDALDATAAA NGMRSDAHAR LMMTRGLKDK
     PFQHPGLSTS GNTLVIIVEH SKPAETLAAR GIRLATVPQV RGLPHSQDPK LNSHSKLNCI
     IACVQAEAAG AEEALMLDPQ GFVNTTNACN FFIVRRGEVW TSTGDYCMNG VTRAKVIDLC
     RANGIPVREK NFSLAEAYGA DEAFLTGTFG AQTAVASIDG NPIGDGTRPV TERIRALYRD
     LVAGDVAQQQ AARPAPAAPA PHPAADFASR FEALAAERSP FCFGADPSPA ILEAWGLPVS
     VAGLREFVSI TLEAIEEGVA LLKPQVAFYE AFGPAGLLEL QRLITGAQAR GVLALADAKR
     TDIGNSVAAY GRAWLGPEGF GADAMTLSAY MGAGTLSPVH EHAAATGTGT FVVVRSSNPE
     GAALQSAEAG GEAVADTLAR AIAAENDRLA PNAPVGPVGA VIGATLGAEA ARTVSLMPNA
     LFLVPGIGAQ GASLDDLSRI FAGAGRRVIP TSSRAVLAAG PDVASLKASI AETRDAAMRL
     RDL
//