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Database: UniProt
Entry: X7YL68_MYCKA
LinkDB: X7YL68_MYCKA
Original site: X7YL68_MYCKA 
ID   X7YL68_MYCKA            Unreviewed;       318 AA.
AC   X7YL68;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   11-DEC-2019, entry version 29.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=I546_4822 {ECO:0000313|EMBL:EUA07942.1};
OS   Mycobacterium kansasii 732.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1299327 {ECO:0000313|EMBL:EUA07942.1};
RN   [1] {ECO:0000313|EMBL:EUA07942.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=732 {ECO:0000313|EMBL:EUA07942.1};
RA   Brown-Elliot B., Wallace R., Lenaerts A., Ordway D., DeGroote M.A.,
RA   Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA   Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC         Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUA07942.1}.
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DR   EMBL; JANZ01000009; EUA07942.1; -; Genomic_DNA.
DR   RefSeq; WP_036404537.1; NZ_JANZ01000009.1.
DR   STRING; 1299327.I546_4822; -.
DR   EnsemblBacteria; EUA07942; EUA07942; I546_4822.
DR   PATRIC; fig|1299327.3.peg.4688; -.
DR   UniPathway; UPA00121; UER00345.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN          3..192
FT                   /note="Prephenate dehydratase"
FT                   /evidence="ECO:0000259|PROSITE:PS51171"
FT   DOMAIN          206..283
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   SITE            185
FT                   /note="Essential for prephenate dehydratase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ   SEQUENCE   318 AA;  33742 MW;  14DE9801D89A1F18 CRC64;
     MVCIAYLGPE GTFTEAALLQ IAAAGLVPRR EAELTELPQR LPVESTPAAL DAVRNGTADF
     ACVPMENSID GSLVPTLDSL AIGSPLQVFA ETTLDVAFSI VVRPGRSAAE VRTLAAFPVA
     AAQVRQWLRA HLPGVEMCPA YSNADAARQV ADGRVDAAVT SPLAAAHWAL ASLADGVVDE
     SSARTRFVLI GRPARPPART GADRTSAVLR IDNVPGALVD ALTEFGMRGI DLTRIESRPT
     RTELGTYMFF VDCVGHIDDD AVAEALKALH RRCADVRYLG SWPTGQADGT APPPPDDASI
     WLARLREGQP APSREFGR
//
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