ID X8CEV1_MYCIT Unreviewed; 889 AA.
AC X8CEV1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=I550_3067 {ECO:0000313|EMBL:EUA54917.1};
OS Mycobacterium intracellulare 1956.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1299331 {ECO:0000313|EMBL:EUA54917.1, ECO:0000313|Proteomes:UP000020825};
RN [1] {ECO:0000313|EMBL:EUA54917.1, ECO:0000313|Proteomes:UP000020825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1956 {ECO:0000313|EMBL:EUA54917.1,
RC ECO:0000313|Proteomes:UP000020825};
RA Zelazny A., Olivier K., Holland S., Lenaerts A., Ordway D., DeGroote M.A.,
RA Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUA54917.1}.
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DR EMBL; JAOG01000002; EUA54917.1; -; Genomic_DNA.
DR AlphaFoldDB; X8CEV1; -.
DR PATRIC; fig|1299331.3.peg.2991; -.
DR Proteomes; UP000020825; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Hydrolase {ECO:0000313|EMBL:EUA54917.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 536..864
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 97567 MW; 3AC205923A97B009 CRC64;
MSIDQKSTNR NPRSTVGTIT EVYDYLRLLY ARAGTPHCPV CGERIARQTP QQIVDQVLAM
PEGTRFQVLA PVVRTRKGEF ADLFEKLNAQ GYSRVRVDGV VHPLTDPPKL KKQEKHDIEV
VVDRLTVKAS AKQRLTDSVE TALNLADGIV VLEFVDHEHD AHNREQRFSE KLACPNGHAL
AVDDLEPRSF SFNSPYGACP ECSGLGIRKE VDPDLVVPDP ERTLAEGAVA PWSTGHTAEY
FTRMMAGLGD ELGFDVDTPW RKLPAKARKA ILEGSDHQVH VRYRNRYGRT RSYYADFEGV
LAFLQRKMAQ TESEQMKERY EGFMRDVPCP VCEGTRLKPE ILAVSLSAGN RGKKSIAEVC
ELSISDCADF LNTLTLGPRE QAIAGQVLKE IQSRLGFLLD VGLEYLSLSR AAATLSGGEA
QRIRLATQIG SGLVGVLYVL DEPSIGLHQR DNRRLIETLT RLRGLGNTLI VVEHDEDTIA
HADWIVDIGP RAGEHGGQIV HSGTYSELLA NKESITGAYL SGKESIEMPA IRRPVDRRRQ
LTVVGAREHN LRGIDVSFPL GVLTSVTGVS GSGKSTLVND ILAAVLANRL NGARLVPGRH
TRVTGLDHLD KLVRVDQSPI GRTPRSNPAT YTGVFDKIRT LFAATTEAKV RGYQPGRFSF
NVKGGRCEAC TGDGTIKIEM NFLPDVYVPC EVCQGARYNR ETLEVHYKGK TISEVLDMSI
EEAAEFFEPI TGIHRYLRTL VDVGLGYVRL GQPAPTLSGG EAQRVKLAAE LQKRSTGRTV
YILDEPTTGL HFDDIRKLLK VINGLVDKGN TVIVIEHNLD VIKTSDWIVD MGPEGGAEGG
TVVAEGTPED VAAVPESYTG KFLAEVIGRS APPASAPTRR PARRRKATA
//
