ID X8CTT5_MYCIT Unreviewed; 1578 AA.
AC X8CTT5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Non-ribosomal peptide synthase TIGR01720 domain protein {ECO:0000313|EMBL:EUA59787.1};
GN ORFNames=I550_2935 {ECO:0000313|EMBL:EUA59787.1};
OS Mycobacterium intracellulare 1956.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1299331 {ECO:0000313|EMBL:EUA59787.1, ECO:0000313|Proteomes:UP000020825};
RN [1] {ECO:0000313|EMBL:EUA59787.1, ECO:0000313|Proteomes:UP000020825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1956 {ECO:0000313|EMBL:EUA59787.1,
RC ECO:0000313|Proteomes:UP000020825};
RA Zelazny A., Olivier K., Holland S., Lenaerts A., Ordway D., DeGroote M.A.,
RA Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUA59787.1}.
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DR EMBL; JAOG01000001; EUA59787.1; -; Genomic_DNA.
DR PATRIC; fig|1299331.3.peg.2864; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000020825; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd19543; DCL_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 532..606
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1547..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1578 AA; 167425 MW; B9253B3D566416DF CRC64;
MTADPAQALS AVDLLDDAEH ARLDALGNRA ALTGPATETD SIPALFAAQA ARTPDTAALV
CDGHSMTYRE LDEASNRLAH LLAARGAGPG QAVALLFSRS AEAIVAILAV LKTGAAYLPI
DPALPAERIG FMLSDAAPIA TLASPGLADR LEGHDVTVIA VDDPELEDRP ATALPAPGPD
HLAYLIYTSG TTGVPKGVAV THHNVTQLLA SKDSGLPRTG VWSQWHSLAF DVSVWEIFGA
LLHGGRLVVV PESVARSPED LHALLVAERV SVLSQTPSAA GALAPAGLES VALVVAGEAC
PAELVDRWAP GRVMINAYGP TEATVYAAIS APLQAGTGAV GPVPIGSPVP NGASFVLDEW
LRPVPPGVVG ELYVAGAGVA CGYWKRAALT ASRFVACPFG APGSRMYRTG DLVRWRADGQ
LDYLGRADEQ VKIRGYRIEL GDVRAALSWV AGVEQAVVVA REDRPGDKRL VGYVTGTADP
AAVRAALAER LPGYMIPAAV VVMQALPLTP NGKLDTRALP APEYSDADQY RAPDNAVEEI
LAGIYAQVLG LERVGVDDSF FDLGGDSISS MQVVTRARAA GLVCKTRDIF VEQTVARLAR
VAEVVDTDAA VLDEGVGPVA ATPIIRWLQD VESVGGQVDQ FNQAMLVQAP TGVTEADVVT
MLQALLDRHP MLRLRVDGSG VQGSGDWSLT VPEAGSVDAA DCLHVVDEVS DAAVTEARSR
LNPAAGVMLS ALWAGATGQL VVIVHHLAVD GVSWRILLQD LNIAWAQHHS GRPVELPAAG
TSFARWSSRL AQHARRPDVV DQAERWTEVA ATPPALPAVR PDVDTFATAG HLFMELDPET
TGALLGEVPS AFHAGVQDIL LIAFALACAE FGGGRAPIGI EVEGHGRHEE LGRDIDLSQT
VGWFTTKYPT ALNVSGVSWG QVVTGGTALG AALKDAKEQL RALPDPLTYG LLRYLNPEID
LDGPEPPIGF NYLGRQGGSG ELTADMWRPV PDGWSVTRAA ASTAMPLMHT LELNAATVDS
ADGPRLHANW TWAPSALDDE QVARLGRLWF AALAGICAHV RSGGGGLTPS DIAPARLSQQ
QLDQLARQHR IADVLALTPV QQGLLFHANT APATDDLYAG QLNISIAGPL DPNRLRDAVH
TVVSRHPNLV ARFCDRYDEP VQIIPADPAP AWRYLELDGT DTDAIERLCA AERAAVCGDL
AEQPAFRVAL VRTASERYRL VLTNHHIVLD GWSMPILLGE IFAAYYGQRL PAAAPYRSFV
SWLADRDLDA ARAAWGQVFA GLDTPTLVGP QDRTELGRQS VESFALPADL TQAVADLARS
CHTTVNTVLQ AAYAQLLCGL TGQRDVVFGT TVSGRPAEIA GADTMVGLLI NTVPVRANIS
AATTTADLLD QLQGAYNHTL DHQHLALNEI HRITGQDALF DTLFAYENYP IDASALSGNH
ELAVTDITSR ESTHYPLTVQ AQPGREMRLQ VEYDTDVFDA ARIATLIERL RRVLAAMTAD
PARRLSSIDL LEPAEHDRLD AWGDRAILTQ PGTPASIPEL FTAQAARTPA RAGGDLRGPV
HDLPRARREL EPAGALAD
//
