ID   X8DRG3_9MYCO            Unreviewed;       507 AA.
AC   X8DRG3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=EPTC-inducible aldehyde dehydrogenase {ECO:0000313|EMBL:EUA70984.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:EUA70984.1};
GN   Name=thcA {ECO:0000313|EMBL:EUA70984.1};
GN   ORFNames=I540_2872 {ECO:0000313|EMBL:EUA70984.1};
OS   Mycobacteroides abscessus subsp. bolletii 1513.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacteroides; Mycobacteroides abscessus.
OX   NCBI_TaxID=1299321 {ECO:0000313|EMBL:EUA70984.1, ECO:0000313|Proteomes:UP000023351};
RN   [1] {ECO:0000313|EMBL:EUA70984.1, ECO:0000313|Proteomes:UP000023351}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1513 {ECO:0000313|EMBL:EUA70984.1,
RC   ECO:0000313|Proteomes:UP000023351};
RA   Zelazny A., Olivier K., Holland S., Lenaerts A., Ordway D., DeGroote M.A.,
RA   Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA   Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUA70984.1}.
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DR   EMBL; JAOJ01000002; EUA70984.1; -; Genomic_DNA.
DR   AlphaFoldDB; X8DRG3; -.
DR   PATRIC; fig|1299321.3.peg.2784; -.
DR   Proteomes; UP000023351; Unassembled WGS sequence.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          28..494
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        263
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   507 AA;  55004 MW;  D6F7CCBB1DDE8B97 CRC64;
     MTVYARPGAQ GSLMTFASRY ENFVGGQWVP PEQGRYFENR TPVTGEVFCE IPRSGEADVE
     KALDAAHAAA PGWARLSPAD RALILNRVAD RMEANLEAIA VAESWDNGKP IRETVNADIP
     LAIDHFRYFA GVLRAQEGSL SQIDEDTVAY HFHEPLGVVG QIIPWNFPLL MASWKLAPAL
     AAGNTVVLKP AEQTPASILY LFSLIGDLLP PGVVNIVNGF GVEAGKPLAS SSRIAKIAFT
     GETSTGRLIM QYASQNLIPV TLELGGKSPN LFFSDVMAGG DDFQDKALEG FTMFAFNQGE
     VCTCPSRSLI QADIFDDFLE LAAIRTKAIR QGDPLDTETM MGAQASHEQL EKILSYIDIG
     KSEGARLVTG GDRADLGGDL SGGYYVTPTV FAGDNSMRIF QEEIFGPVLA VTSFADYDDA
     IAIANDTPYG LGAGVWSRNG NIAYRAGRDI KAGRVWTNCY HQYPAHAAFG GYKRSGIGRE
     NHKMMLDHYQ QTKNLLVSYG TKAQGFF
//