ID X8DYA5_9MYCO Unreviewed; 1334 AA.
AC X8DYA5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:EUA73627.1};
GN ORFNames=I540_0302 {ECO:0000313|EMBL:EUA73627.1};
OS Mycobacteroides abscessus subsp. bolletii 1513.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=1299321 {ECO:0000313|EMBL:EUA73627.1, ECO:0000313|Proteomes:UP000023351};
RN [1] {ECO:0000313|EMBL:EUA73627.1, ECO:0000313|Proteomes:UP000023351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1513 {ECO:0000313|EMBL:EUA73627.1,
RC ECO:0000313|Proteomes:UP000023351};
RA Zelazny A., Olivier K., Holland S., Lenaerts A., Ordway D., DeGroote M.A.,
RA Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUA73627.1}.
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DR EMBL; JAOJ01000001; EUA73627.1; -; Genomic_DNA.
DR PATRIC; fig|1299321.3.peg.280; -.
DR Proteomes; UP000023351; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR012728; NRPS_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR02353; NRPS_term_dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 856..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1101..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1127..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 527..601
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1334 AA; 140951 MW; E6998FE81021A10E CRC64;
MSRAHQEAPD SAPEHAPQPV AQQAPAHPVP PQYLLGRSAP AARTLIDILY ATAAENPDAP
AIDDGTIQLT YSELIVDMEA SVEWLGARGI GRGDRVGIRM PSGSYSLYVA ILATLAAGAA
YVPVDADDPD ERAALVFGEA QVAAVITPGG LVRGPGSSRG WRAAKPTPRD DAWIIFTSGS
TGTPKGVAVT HRNAAAFVDA EAQMFLQDNP IGPDDRVLAG LSVAFDASCE EMWLAWRYGA
CLVPAPRSLV RSGMDLGPWL VSRDVTVVST VPTLAALWPA EALEAVRLLI FGGEACPPDL
AERLATGEDG AAREVWNTYG PTEATVVACA ARLDGVSPVS IGLPLPGWDL AVVDPQGNQV
GYGEVGELVI GGIGLAKYLD PDKDAEKYAP LDTLGWSRAY RSGDLVRLEP DGLYFQGRAD
DQVKVGGRRI ELGEVDAALV NLPGVSAGAA AVRKTASGTP LLVGYIASAD PNFDIAAARA
SLAESLPAAL VPRLVKLDEL PTRTSGKVDR NALPWPPPGA GADDEAPELG GTMGWLAGLW
RDILAAPVDG PEADFFALGG GSLSAAQLVA ALRQRYPQVT VANLYDQPRL GSLATYLDEL
APPVEVEPRV VKPVPRLAEL AQLVATLPLT TLTGLQWATW LALANNVFAT FSGVPWLVTV
NWWVLLAAFV LFITPLGRMS ITVIGARLLL SGVKPGTYER GGSVHLRVWI ADRLATASGA
ENLSGAPWMV YYARALGARV GNGVDLHSSP PVTGWLELGD RSSVEPEVDL SGHWVDGDKF
HVGPIVIGDD ATVGARTTLL PGAVVGKNAD VAPASGVVGR VKNGQYWKGS PAVKSGKARH
PWPDYRPPRA GQWVPIYGLT SILLGGLPLL ALAAGLAVVA YGIRDAATIC GAVVPALMWT
PAAALVSVVV YAAITVVLVR LLSLGVHEGY HPVRSRQGWQ LWATERLMDA ARNYLFPIYA
SQLTPWWLRI LGAKIGKDTE ISTALLVPKF TEVDDGAFLA DDTMVASYEL GGGWIHIAKA
RIGKRAFLGN SGITQPGRKV PNDALVAVLS ATPHKAKSGS SWIGSPPKRL RRKADGADST
LTFEPPFRLK VMRGIVETCR IIPIIVTFGI GVGVLLTLQN IAIRFNFWVA GALSGVVLLI
AGAVAGVVSV VAKWLVVGRT KAVEKPLWSS FVWRNEVADT FVETVAAVWF ARAASGTIMQ
NWWLRGLGAK IGRGVWCETY WLPEADLVTL GRGATVNRGC VVQTHLFHDR IMRMDTVVLG
EGATLGPHCV ALPAAELGAG ATVGPASLVV RGDVVPPSTR WQGNPISPWG KLDPMAPKKP
KSGKVSPNRN SGAA
//
