ID XPO4_DANRE Reviewed; 1150 AA.
AC Q802D3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Exportin-4;
GN Name=xpo4; ORFNames=zgc:55678;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC substrate specificity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; BC048882; AAH48882.1; -; mRNA.
DR RefSeq; NP_997839.1; NM_212674.2.
DR AlphaFoldDB; Q802D3; -.
DR SMR; Q802D3; -.
DR STRING; 7955.ENSDARP00000112894; -.
DR PaxDb; 7955-ENSDARP00000005176; -.
DR PeptideAtlas; Q802D3; -.
DR GeneID; 324342; -.
DR KEGG; dre:324342; -.
DR AGR; ZFIN:ZDB-GENE-030131-3062; -.
DR CTD; 64328; -.
DR ZFIN; ZDB-GENE-030131-3062; xpo4.
DR eggNOG; KOG4541; Eukaryota.
DR InParanoid; Q802D3; -.
DR OrthoDB; 763157at2759; -.
DR PhylomeDB; Q802D3; -.
DR PRO; PR:Q802D3; -.
DR Proteomes; UP000000437; Alternate scaffold 9.
DR Proteomes; UP000000437; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014877; XPO1_C_dom.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; EXPORTIN 4,7-RELATED; 1.
DR PANTHER; PTHR12596:SF1; EXPORTIN-4; 1.
DR Pfam; PF08767; CRM1_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1150
FT /note="Exportin-4"
FT /id="PRO_0000237671"
SQ SEQUENCE 1150 AA; 129227 MW; C6CBF583D4108EB7 CRC64;
MMAAVGAPEV ISQLESAAKV LMAPPSMVST EQRQHAEHIF LSFRKSKSPF AVCKHILETS
KVDYVLFQAA TAIMEAVVRE WILLEKNSIE SLRTFLLTYV LQRPNLQKYV REQILLAVAV
IVKRGSLDKS INCKSIFLEV SQLISSGNPT VQTLACSILT ALLSEFSSSN KTSNIGLSME
FHGSCKRIFQ EDDLRQIFML TMEVLQEFSR RENLNAQMSC VFQRYLALAN QVLSWNFLPP
NLGRHYIAMF EATPNVMLKP TESWRESLLD HRVMDLFFTV HRKIREDSDM AQDSLQCLAQ
LASMQGPIFP DESAQVTYLA HLVEGLLNMI NGIEIEDSEA VGISNIISNL ISTFSRSVLT
ALPNVLFASF INCLTLLTCS FGRSAALEEV LDKDDMVYME AYDKLLESWL TLVQEDEHFP
RGCFVQPAVQ VFNSYIQCHL AAPDGTRNLT ANGVASHEEE EINELQEDDR ELFSDQLASI
GMLGRIAADH CIPLLTGLLE DRVTRLHGQL QRHQQHLMAA ADPDTVDRKV LDDLYEDIHW
LILVSGYLLA DVPQGETPLI PSEVMEYSIK HSTEVDINTT LQLLGSPGEK ATSIPGCNRT
DSVIRLLSAV LRTSEVESRA TRASLTQLLS PQMGKDIVWF LRRWAKTYLL VDEKLYGQIS
MPLSTAFGAD TEGAQWIVGY LLEKVINNLS VWSSEPELAN DTVELLVTLV EKRERANIVV
QCENWWSLAK QFASRSPPLH MLSSTVQRTL MKALVLGGFA HMDSDTKQQY WAEVLHPLQQ
RFLNLINQEN FAQICQEVAV KQEIVATLEA LCGIAEATQI DNVASLFSFL MDFLSSCIGL
MEVYRNSPET VNLIIEVFVE VAHKQICYLG ETKSMKLYEV CLTLLQVYSK NNLGRKRLDV
AAEEDQYQDL LLIMELLTNL LSKEFIDFSD TDEVLRGQEQ SSGAGRAVSA ADVVLYGVNI
VLPLMSQDLL KFPSLCNQYY KLITFICEIF PEKIPQLPEE LFKSLMCSLE LGMTSMSSEI
SQLCLEALSP LAEQCAKTQE KDTPLFIATR HFLKLVFDML VLQKHNTEMT VAAGEALYTL
VCLHQAEYSE LVETLLSNQR DALIYQRLAD AFNNLTASST PPTMDRKQKV AFLKSLEEFV
ANVGGLLCVK
//
