ID XPOT_CRYNJ Reviewed; 1139 AA.
AC P0CN64; Q55S99; Q5KGP6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=LOS1; OrderedLocusNames=CNE02810;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AE017345; AAW43682.1; -; Genomic_DNA.
DR RefSeq; XP_570989.1; XM_570989.1.
DR AlphaFoldDB; P0CN64; -.
DR SMR; P0CN64; -.
DR STRING; 214684.P0CN64; -.
DR PaxDb; 214684-P0CN64; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_0_1; -.
DR InParanoid; P0CN64; -.
DR OMA; CALIDCH; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 2.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1139
FT /note="Exportin-T"
FT /id="PRO_0000343091"
FT REGION 562..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 125740 MW; 7F623F621382395F CRC64;
MAATSPHLTS IPQAVRVAAS IDPSIDPGLK QQAIDYLTKV KQLSEETWQL YLQGAGAPGP
STTGRDGKEK LETDMRMFCL QVVDTVLIQK PEVMGADAVQ GMYEAIVEFI QVEYIGGSCE
GGQGFLRNKL AFTISQLFLR AFPSHIPTFL HPFFALLSPP TSSPPNLHPQ LLTIRLLLEI
AQEIHDTTLK TARIMTKERQ ERDGVVRDVI RSSGDDKTAV QGMLGIIEKG LEQMNSGNSS
DKWAEAVDAT LKTLSAWIPW IDLGVALNPT TLPFYHRLLH QPILSFRTAT AGIYRTLVAK
GIQDPSSRLQ VLRVLAPVAV IDPLETETRG GKSEEVATFR ASLGVVLSAY GVALIGISDN
TEVAEQLRNE AEEMMNPALP LLLRFLSDRQ YEVPLSVSPF VSDLLRIYKR MYKPPNPSTK
AGQAPSPPST LPQLSPERRQ FLASMLDILI RQLAWPEDTE WEAPGNEDEL DEDIAAFKNF
RGSCRSFIES IAQIDKSLHT EVVARIVIAT LDAYASGGGA AAVPWQQAEL AMHLVYTFGE
VSKNSTRAAF YELPPEMATK AARNKLRAAQ GSGRTTPSSS DNVDLGPSSN NDRLEYEQFP
LSPLGQLLTR CMTSGISSYP HPSVTLQYFE IIVRYIEFWK AKPETLPGLF EALLDGQGIH
NSDEGVRRRC FYLFSKLCKD CRNDTVEGMV SPILDSMRDM MVINAELPPT DTPDEDPLIK
ATTGKSYVAD QLYLFEASGN LVYLTKADPA KQMALLEAVA GPLLSGLGSG VERARVDEND
LQAVLQVHHH LMALGHFAKG FPIVPDKLVE LLPYTGPFKQ MAEALLQAIE ILKRRRVVRD
AARFAFSQFA NAIGTPVAEL VPRFVSAVVT EFEPSELVDF LLFLQLLMHR LQGSTFETMD
MLLLPLLSRI FTVLQQPVTG TDEAQVHARL KDAYLAFFTS LMNENLDGIF ITDRNKPEFE
NVLTTLFNLT QDYSDGASQR LAFGFFSRSV IAWGTSPEAA ARPSVFAESA MASQSKMVSG
GGTAQPNAHA VTQEQRAKQC LPGYENFIYQ RLLPAAFEVP ANSQFNIRGG QLIVHEAAVL
VRNTVQARGQ EAIDFMLSDL LRRLNCPSDI ANQLIASLTT QQAKDFKKTF FDFIKAMRG
//
