ID Y2281_MYCTU Reviewed; 552 AA.
AC P9WIA5; L0TAQ9; P65712; Q50684;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Putative phosphate permease Rv2281;
GN OrderedLocusNames=Rv2281; ORFNames=MTCY339.29c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
CC -!- FUNCTION: Potential transporter for phosphate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP45063.1; -; Genomic_DNA.
DR PIR; E70731; E70731.
DR RefSeq; NP_216797.1; NC_000962.3.
DR RefSeq; WP_003411694.1; NZ_NVQJ01000012.1.
DR AlphaFoldDB; P9WIA5; -.
DR SMR; P9WIA5; -.
DR STRING; 83332.Rv2281; -.
DR PaxDb; 83332-Rv2281; -.
DR GeneID; 45426261; -.
DR GeneID; 887257; -.
DR KEGG; mtu:Rv2281; -.
DR PATRIC; fig|83332.111.peg.2536; -.
DR TubercuList; Rv2281; -.
DR eggNOG; COG0306; Bacteria.
DR InParanoid; P9WIA5; -.
DR OrthoDB; 9779554at2; -.
DR PhylomeDB; P9WIA5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF80; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..552
FT /note="Putative phosphate permease Rv2281"
FT /id="PRO_0000080801"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 552 AA; 58789 MW; 050847C107DA3716 CRC64;
MSDNAKHHRD GHLVASGLQD RAARTPQHEG FLGPDRPWHL SFSLLLAGSF VLFSWWAFDY
AGSGANKVIL VLATVVGMFM AFNVGGNDVA NSFGTSVGAG TLTMKQALLV AAIFEVSGAV
IAGGDVTETI RSGIVDLSGV SVDPRDFMNI MLSALSAAAL WLLFANRMGY PVSTTHSIIG
GIVGAAIALG MVSGQGGAAL RMVQWDQIGQ IVVSWVLSPV LGGLVSYLLY GVIKRHILLY
NEQAERRLTE IKKERIAHRE RHKAAFDRLT EIQQIAYTGA LARDAVAANR KDFDPDELES
DYYRELHEID AKTSSVDAFR ALQNWVPLVA AAGSMIIVAM LLFKGFKHMH LGLTTMNNYF
IIAMVGAAVW MATFIFAKTL RGESLSRSTF LMFSWMQVFT ASGFAFSHGS NDIANAIGPF
AAILDVLRTG AIEGNAAVPA AAMVTFGVAL CAGLWFIGRR VIATVGHNLT TMHPASGFAA
ELSAAGVVMG ATVLGLPVSS THILIGAVLG VGIVNRSTNW GLMKPIVLAW VITLPSAAIL
ASVGLVALRA IF
//
